Ayman Wahba Erian

The Chemistry of α-Haloketones and Their Utility in Heterocyclic Synthesis

The molecular structures and spectral properties of α-haloketones as well as their syntheses are analyzed and reviewed. Their reactivity towards oxygen, nitrogen, and sulfur nucleophiles, carboxylic acids, carbon nucleophiles, alkenes, and alkynes are discussed.

Studies on alkylheteroaromatic compounds: the reactivity of alkyl polyfunctionally substituted azines towards electrophilic reagents

Abstract Several new alkylpyridine, pyridazine and pyrimidine derivatives are synthesized from acyclic intermediates. The reactivity of these alkylazines towards aromatic aldehydes and arylidenemalononitrile is reported. New synthesis for substituted phthalazines cinnolines and quinazolines could be achieved.

β-enaminonitriles in heterocyclic synthesis: A novel synthesis and transformations of α-substituted-β-enaminonitriles

Abstract Novel synthesis of α-substituted-β-enaminonitriles could be obtained from reaction of β-enaminonitriles with paraformaldehyde and dimethylamine. Such compounds reacted readily with a wide variety of reagents to give unique heterocyclic systems.

Studies With Pyridinethiones: A Convenient Synthesis of Polyfunctionally Substituted Pyridine Ring Systems

Abstract 1-Benzoyl-1-phenylsulfone-2-ethoxyethene 3 has been prepared via reaction of phenacyl sulfone 1 with triethylorthoformate. Compound 3 can be used for prepration of pyridinethione, which could be annulated into fused various heterocyclic ring systems.

A novel synthesis of phosphorus heterocycles. Reaction of α-hydrazidoyl halides with phosphoranes and Lawesson's reagent

Hydrazidoyl halides 1a reacted with diethylphosphonoacetonitrile (2a) in sodium ethoxide to yield the hydrazine derivative 4a which readily cyclized to form the corresponding diazaphosphole 5 . The latter was hydrolyzed to form the final product 6, with the formation of a low yield of a second product 7a . Similarly 1b, c reacted with diethylphosphonoacetonitrile and triethylphosphonoacetate 2a, b to produce the corresponding diazaphospholes 6b–d . Interaction of hydrazidoyl halides 1b, d–g with Lawessons reagent in dry toluene produced 1,3,4-thiadiazaphosphole derivatives 10b, d, e and 11f, g respectively.

Phosphonium Ylides In Organic Synthesis III. 12 A Novel Synthesis Of α-Substituted Ylides and Pyrazole Systems

Abstract A novel synthesis of a-substituted phosphonium ylides and pyrazole systems via the treatment of hydrazonoyl halides 1 with phosphoranes 2 and 6, respectively is reported.

HYDRAZONES IN HETEROCYCLIC SYNTHESIS; SYNTHESIS OF 1,3,4-THIADIAZOLE DERIVATIVES

Abstract A new synthesis of 1,3,4-thiadiazoles has been achieved. The reactivity of certain alkylheterocycles towards electrophilic reagents are reported.

Heterocyclic Sulfonesiv: A Novel Synthesis of Pyrrole and Fused Heterocyclic Sulfones

Abstract The applicability and synthetic potency of the reagent diethyl 2-aryl-3-phenylsulfonylpropen-l,1-dicarboxylate 3 is reported. Compound 3 proved to be a key precursor in heterocyclic sulfones synthesis. Chemical and spectroscopic evidences for the structure of the newly synthesized compounds are described.

Diethyl 2-Aryl-3-cyanopropene-1,1-dicarboxylates: New Versatile Precursors in Heterocyclic Synthesis

Summary. An expeditious synthetic route for the title precursor is reported. It provides access to a variety of polyfunctionally substituted pyridines, pyridazines, pyrazolopyridines, thiophenes, and thienopyridines.Zusammenfassung. Eine einfache Synthese zur Darstellung des im Titel genannten Synthons wird beschrieben. Es vermittelt den Zugang zu polyfunktionell substituierten Pyridinen, Pyridazinen, Pyrazolopyridinen, Thiophenen und Thienopyridinen.

2-Aryl-1,1-dicyano-3-phenylsulfonylpropenes in Heterocyclic Synthesis: A Synthetic Strategy Towards Heterocyclic Sulfones

Summary. The applicability and synthetic potency of the novel reagent 1-aryl-1,1-dicyano-3-phenylsulfonylpropene for the development of an expeditious synthetic approach to unique polyfunctionally substituted heterocyclic sulfone systems is reported. Chemical and spectroscopic evidences for the structures of the new compounds are presented.Zusammenfassung. Die Anwendbarkeit und synthetische Brauchbarkeit des neuen Reagens 1-Aryl-1,1-dicyano-3-phenylsulfonylpropen für eine rasch durchführbare Synthese von polyfunktionell substiuierten heterocyclischen Sulfonen wird vorgestellt. Die chemischen und spektroskopischen Daten werden als Evidenz für die Stukturen der neuen Verbindungen präsentiert.