Abdussemet Hazar

Thymoquinone protects end organs from abdominal aorta ischemia/reperfusion injury in a rat model

Introduction Previous studies have demonstrated that thymoquinone has protective effects against ischemia reperfusion injury to various organs like lungs, kidneys and liver in different experimental models. Objective We aimed to determine whether thymoquinone has favorable effects on lung, renal, heart tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. Methods Thirty rats were divided into three groups as sham (n=10), control (n=10) and thymoquinone (TQ) treatment group (n=10). Control and TQ-treatment groups underwent abdominal aorta ischemia for 45 minutes followed by a 120-min period of reperfusion. In the TQ-treatment group, thymoquinone was given 5 minutes. before reperfusion at a dose of 20 mg/kg via an intraperitoneal route. Total antioxidant capacity, total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured and lung, kidney, and heart tissue histopathology were evaluated with light microscopy. Results Total oxidative status and oxidative stress index activity in blood samples were statistically higher in the control group compared to the sham and TQ-treatment groups (P<0.001 for TOS and OSI). Control group injury scores were statistically higher compared to sham and TQ-treatment groups (P<0.001 for all comparisons). Conclusion Thymoquinone administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta ischemia-reperfusion rat model.

Bilateral Extracranial Internal Carotid Artery Aneurysm: Original Image

A 63-year-old woman was admitted to our clinic with the complaint of dizziness. Doppler ultrasound and computerized tomography angiography scan demonstrated bilateral fusiform internal carotid artery aneurysms (Figure 1). Left internal carotid artery’s diameter was 21 mm and right internal carotid artery’s diameter was 11 mm. The patient refused endovascular stent grafting, therefore medical treatment was given including antiaggregants and antihypertensives.

Massive right main pulmonary embolism caused by tricuspid valve infective endocarditis

We describe a rare case of bacterial endocarditis with large vegetation and substantial pulmonary embolism. A 29-year-old woman who had acute renal failure after a septic abortion developed tricuspid valve endocarditis with large vegetation, which subsequently resulted in massive embolism to the right main pulmonary artery. The patient presented with symptoms of dyspnoea. Physical examination disclosed non-laboured breathing, with equal breath sounds bilaterally. Laboratory tests showed only leucocytosis and increased levels of C-reactive protein. Chest radiography showed a peripheral right …

Koroner bypass ameliyatı öncesi trimetazidin kullanımının oksidatif parametreler üzerine etkileri

Amac: Koroner arter bypass greft cerrahi (KABG)\sinde olusan miyokardiyal iskemi- reperfuzyon hasari uzerinde trimetazidin (TMZ) kullaniminin koruyucu etkisinin prospektif olarak arastirilmasi amaclandi. Yontemler: 2008-2009 yillari arasinda klinigimizde elektif sartlarda KABG ameliyatina alinan 35 hasta calismaya dahil edildi. Olgular randomize olarak iki gruba ayrildi. Olgularin 17\sine ameliyattan iki hafta oncesinden TMZ verildi, kontrol grubundaki 18 hastaya verilmedi. Hastalardan ameliyat oncesi, ameliyat esnasi ve ameliyat sonrasinda venoz ve kardiyopulmoner bypass baslarken ve sonrasi donemde koroner sinus kan ornekleri alindi. Calisma sonunda total oksidatif durum (TOS) ve total antioksidan kapasite (TAS) calisildi ve oksidatif stres indeksi (OSI) hesaplandi. Oksidatif parametreler uzerinde ameliyat stresi ve trimetazidin kullaniminin etkisi tekrarlayan olcumler varyans analizi ile incelendi. Bulgular: Trimetazidin kullaniminin total antioksidan kapasite, total oksidatif stres ve oksidatif stres indeksi uzerinde istatistiksel anlamli etkisi olmadigi tespit edildi (p>0,05). Buna karsin tekrarlayan olcumlerde oksidatif stres parametrelerinde ameliyat stresinin etkilerini yansitacak sekilde istatistiksel anlamli degisiklikler saptandi (p