Abha Chandra

Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation

OBJECTIVE The purpose of this study was to evaluate the efficacy of prophylactic single-dose amiodarone administered through the pump circuit before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation (RVF). DESIGN A prospective, randomized double-blind, placebo-controlled efficacy study. SETTING A tertiary level teaching hospital. INTERVENTION Seventeen patients received 150 mg of amiodarone in 10 mL of normal saline by way of the pump 3 minutes before releasing the ACC, and a control group of 17 patients received 10 mL of normal saline. MEASUREMENT AND MAIN RESULTS The primary outcome of the study was the incidence of ventricular fibrillation requiring defibrillation during the 30-minute period after myocardial reperfusion. A large decrease in RVF (65% to 18%) was observed in the amiodarone-treated group with the number needed to treat only 2.1.The myocardial performance in terms of cardiac output was better in the amiodarone group; this could be attributed to the lower incidence of RVF and subsequent direct current shock therapy. CONCLUSIONS The observations showed that single-dose prophylactic amiodarone administered through the pump circuit 3 minutes before ACC release was an effective therapy to reduce the incidence of post-ACC release ventricular arrhythmias.

The effect on post-operative pain of intravenous clonidine given before induction of anaesthesia.

Background: Treatment of acute post-thoracotomy pain is particularly important not only to keep the patient comfortable but also to minimize pulmonary complications. Aim: This study was designed to test the effect of pre-induction administration of clonidine, given as a single intravenous dose, on post-operative pain scores and fentanyl consumption in patients after thoracic surgery. Setting and Design: Tertiary referral centre. Prospective, randomised, double-blind, placebo-controlled trial. Methods: Sixty patients were randomly allocated to receive clonidine (3 mcg/kg) or saline pre-operatively before induction of anaesthesia. The primary endpoint was pain on coughing (visual analogue scale (VAS) 0–100 mm) 120 min after surgery, time to first analgesic injection in the post-anaesthesia care unit (PACU) and 24-h fentanyl consumption. Statistical Analysis: For between-group comparisons, t-test and U-test were used as appropriate after checking normality of distribution. The incidence of complications between the groups was compared by Fishers exact test. Results: The post-operative VAS for the first 120 min and the fentanyl consumption at 24 h was significantly greater in the placebo group compared with the clonidine group (P<0.05). The sedation score was increased in the clonidine group during study drug infusion, but did not differ significantly on admission to the PACU. Conclusions: A single intravenous dose of clonidine (3 mcg/kg) given before induction of anaesthesia significantly reduced the post-operative VAS score in the initial period and fentanyl consumption during 24 h after thoracic surgery.

Coronary Artery Bypass in Patients with Severe Left Ventricular Dysfunction

We retrospectively reviewed the case records of 82 patients with severe left ventricular dysfunction (ejection fraction < 30%) who underwent coronary artery bypass grafting between March 1993 and February 2000. They were aged 28 to 76 years (mean, 60 years), and 66 of them were male. Significant comorbid factors included hypertension (93%), diabetes mellitus (85%), and hypercholesterolemia (49%). The number of grafts used ranged from 1 to 3. The majority of the patients (91%) belonged to the Canadian Cardiovascular Society angina class III. Coronary angiography revealed single-vessel (in 16% of the patients), double-vessel (52%), and triple-vessel disease (32%), and left main stem disease (18%). Seven patients (9%) died within 48 hours after surgery. The mean duration of hospital stay was 7 ± 2 days. The 75 patients who survived were followed up for 3 months to 7 years. At the 1-year follow-up, 61 of the 68 patients (90%) who were alive moved up from angina class III to class I. Our observations suggest that coronary bypass carries an acceptable mortality risk and may offer a better quality of life in patients with poor ventricular function.

Spirometric Changes following Open-Heart Surgery on Rheumatic Mitral Valves

Evaluation of pulmonary function by spirometry in adult patients undergoing cardiac surgery is a simple test to assess pulmonary reserve that has important implications in the operative morbidity. Pulmonary function was studied preoperatively, before discharge, and at the 3-month follow-up in 22 randomly selected patients who underwent open-heart surgery for rheumatic mitral valve disease (2 reconstructions, 20 replacements). The mean preoperative cardiothoracic ratio was 0.58. Lung function was found to be impaired preoperatively in all 22 patients and the majority suffered from restrictive lung disease. Better preoperative lung function was seen in nonsmokers, patients with a cardiothoracic ratio of less than 0.50, and those with a normal pulmonary artery pressure. After mitral valve surgery, the mean pulmonary artery pressure was 20.6 ± 2.9 mm Hg, the mean mitral valve pressure gradient was 3.6 ± 2.4 mm Hg, and the mean cardiothoracic ratio was 0.52 ± 0.09. A significant deterioration was seen in the predischarge spirometric values of forced vital capacity, forced expiratory volume in one second, peak expiratory flow rate, flow rate at 25% to 75% of expired vital capacity, and maximum volume ventilation. The deterioration was greater in smokers and those who had prolonged cardiopulmonary bypass (more than 80 minutes). No correlation was found with ventilation because all patients were electively ventilated overnight. There was an overall improvement in spirometric parameters at the 3-month follow-up although the values remained lower than predicted. Spirometry was found to be useful for assessing lung function in patients undergoing mitral valve surgery and we recommended it as a routine test.

Hyperbilirubinemia after Cardiopulmonary Bypass: A Prospective Study

Postoperative hyperbilirubinemia is one of the complications of cardiopulmonary bypass. This prospective study was conducted on 77 patients who underwent open-heart surgery, to evaluate the incidence, risk factors, and prognostic significance of postoperative hyperbilirubinemia. Liver function tests were conducted preoperatively, immediately after surgery and on the 1st, 3rd, and 7th postoperative days. The overall incidence of postoperative hyperbilirubinemia was 26%. The incidence was significantly higher in patients who underwent prosthetic valve replacements (31%) than in those without prostheses (22%) and very high in patients undergoing double valve replacement (50%) compared to single valve replacement (27%). Most (90%) of the increase in serum bilirubin was due to a rise in unconjugated bilirubin on the 1st postoperative day. There was no mortality related to postoperative hyperbilirubinemia but it prolonged intensive care stay when it occurred early after surgery and prolonged hospital stay when it occurred later. Preoperative total bilirubin concentration, number of valves to be replaced, and preoperative high right atrial pressure were the factors associated with increased risk of postoperative hyperbilirubinemia by logistic regression analysis.

Closed Mitral Valvotomy versus Balloon Valvuloplasty: A Comparison of 100 Cases:

From January 1995 to December 1996, 50 patients with mitral stenosis underwent surgical valvotomy and another 50 had balloon mitral valvuloplasty. Balloon valvuloplasty was performed by the Inoue technique and surgical closed mitral valvotomy was carried out through a standard anterolateral thoracotomy with transventricular repeated Tubbs or finger dilatation. Functional status, left atrial mean transmitral gradient, mitral valve area, and left atrial size were recorded. No significant difference was found between the values of these parameters in the 2 groups of patients at the end of the study.

Well-differentiated fetal adenocarcinoma of the lung in an adult male: Report of an unusual tumor with a brief review of literature

We report a case of a well-differentiated fetal adenocarcinoma (WDFA) of the lung in a 50-year-old male smoker. The literature regarding this uncommon tumor is limited. This rare variant of adenocarcinoma is more common in females, in the third and fourth decades. Microscopically it is composed of neoplastic glands and tubules that resemble the fetal lung. Well-differentiated fetal adenocarcinoma is a low-grade malignancy and surgery is the preferred mode of therapy. This uncommon case of a well-differentiated fetal adenocarcinoma in an adult male patient is reported, with relevant immunohistochemical findings, along with a discussion of the current literature.

Anomalous Origin and Course of Left Anterior Descending Coronary Artery

A 56-year-old female with exertional angina had signs of ischemia on an exercise electrocardiogram. Coronary arteriography revealed anomalous origin of the left anterior descending coronary artery from the right coronary artery. The initial portion was septal and it then coursed between the aorta and the pulmonary artery. The patient declined surgical revascularization.

A case of solitary pulmonary nodule (large pulmonary chondroid hamartoma)

Chondroid hamartomas are rare benign tumors of the lung which show predominantly cartilage. Usually, they are small, solitary, and asymptomatic lesions. They are detected incidentally on chest X-ray or at the time of autopsy. Occasionally, large pulmonary hamartomas are encountered. We present a case of a 60-year-old male patient with a 6-month history of cough. His X-ray and computed tomography (CT) scan of the chest revealed a well-defined soft-tissue density lesion with popcorn calcification measuring 6.5 cm × 4.8 cm in the left lung upper lobe. A presumptive diagnosis of chondroid hamartoma was made in CT-guided percutaneous biopsy. A posterolateral thoracotomy and left upper lobectomy were done. There was a spherical gray-white firm mass noted in the resected lobectomy specimen. Postoperative histopathological examination confirmed the diagnosis of pulmonary chondroid hamartoma. This is an additional case of large chondroid hamartoma.

Glandular myxoma of left atrium: An uncommon tumor

In the present day, there is an overall increase in the incidence of various tumors of the body though tumors of the heart are not common. Metastatic tumors of the heart are more common than primary tumors. Among primary tumors of the heart, myxoma is the most common tumor. However, glandular differentiation in myxoma is rare. Hereby, we present a rare case report of glandular differentiation in cardiac myxoma of the left atrium.