Abu Zeid A. Hassanien

β-Amino-β-(pyrid-4-yl)acrylonitrile in heterocyclic synthesis: synthesis of some new pyridine, pyridone, pyrazole, thiophene, fused pyrimidine and triazine derivatives

Abstract β-Amino-β-(pyrid-4-yl)acrylonitrile reacts with various types of reagents with variable molar ratios under different conditions to yield pyridine derivatives and condensed heterocyclic compounds containing a pyridyl moiety.

Phthalazinone in Heterocyclic Synthesis: Synthesis of Some s-Triazole, s-Triazolothiadiazine, s-Triazolothiadiazine, and s-Triazolothiadiazole Derivatives as Pharmaceutical Interest

1(2H)-Oxophthalazine-2-acetic acid ethyl ester was allowed to react with various reagents under different conditions to yield compounds 2-[(4-substituted-5-mercaptotriazol-3-yl) methyl]-1 (2H)-oxophthalzines 5 and 7 which acted as starting materials for the preparation of some new s-triazolo[5,1-b][1,3]thiazine (8), s-triazolo[3,4-b][1,3,4]thiadiazine 9,12,14,20, and s-triazolo[3,4-b][1,3,4]thiadiazole 18,21 derivatives. The author sincerely thank Dr. Ahmed A. El-Beih, Department of Natural and Microbial Products, National Research Center, Cairo, Egypt for antimicrobial data.

Aminomethylene ketones and enamines in heterocyclic synthesis : synthesis of functionally substituted pyridine, pyrazole, fused pyrimidine and fused [1,5]diazocine derivatives

Methyl 2-benzoyl-3-dimethylaminopropenoate (2) and 2-(benzimidazo-2-yl)-3-dimethylaminoacrylonitrile (27) were condensed with various type of reagents under different conditions to afford new acyclic, cyclic and fused heterocyclic derivatives.

Utility of [( p -Sulfonamidophenyl)azo]malononitrile in the Synthesis of Polyfunctionally Substituted Pyrimidine, Pyrazole, Isoxazole and Pyridazine Derivatives

[(p-Sulfonamidophenyl)azo]malononitrile and/or [(p-sulfonamidophenyl)azo]acrylonitrile derivatives react with various reagents to afford pyrimidine, pyrazole, isooxazole and pyridazine derivatives with interesting biological activities via initial addition to either the cyano or amino group followed by cyclization.

Nitriles in heterocyclic synthesis: the preparation of novel indeno[1,2-d]pyridazines, fused pyrazolo [5,1-c][1,2,4]triazines, and fluorenones

Treatment of the novel compound (2-cyano-1-oxo-1H-indene-3-yl) acetonitrile (3) with various reagents affords a variety of heterocyclic compounds in which the indenone system is incorporated into polycyclic compounds of potential pharmacological interest.