Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Said Ahmed Soliman Ghozlan is active.

Publication


Featured researches published by Said Ahmed Soliman Ghozlan.


Tetrahedron | 2002

β-Amino-β-(pyrid-4-yl)acrylonitrile in heterocyclic synthesis: synthesis of some new pyridine, pyridone, pyrazole, thiophene, fused pyrimidine and triazine derivatives

Said Ahmed Soliman Ghozlan; Abu Zeid A. Hassanien

Abstract β-Amino-β-(pyrid-4-yl)acrylonitrile reacts with various types of reagents with variable molar ratios under different conditions to yield pyridine derivatives and condensed heterocyclic compounds containing a pyridyl moiety.


Monatshefte Fur Chemie | 1981

Reactions with heterocyclic amidines, VII: Synthesis of some new pyrazolo[1,5-c]-1,2,4-triazines, pyrazolo[1,5-a]-1,3,5-triazines and pyrazolo[1,5-a]pyrimidines

Mohamed Hilmy Elnagdi; Ezzat Mohamed Zayed; M. A. Elsayed Khalifa; Said Ahmed Soliman Ghozlan

Diazotised 5-amino-3-methyl-4-phenyloyrazole (1) reacted with active methylene reagents and with β-naphthol to yield the pyrazolo[1,5-c)-1,2,4-triazine derivatives2a-e and5. Compound1 reacted with benzoyl isothiocyanate and with phenyl isothiocyanate to yield the corresponding pyrazol-5-ylthiourea derivatives6a, b. 5a was converted into the thiourea derivative8 by the action of acids or alkalies. A synthesis of 2-methyl-3-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidin-5-one from the reaction of α-phenylacetoactonitrile (3-oxo-2-phenyl-butyric nitrile) and β-cyanoethylhydrazine is reported.ZusammenfassungDiazotiertes 5-Amino-3-methyl-4-phenylpyrazol (1) reagiert mit einer aktiven Methylenkomponente und β-Naphthol zu den Pyrazolo[1,5-c]-1,2,4-triazin-Derivaten2a-e und5. 1 ergibt mit Benzoylisothiocyanat und Phenylisothiocyanat die entsprechenden Pyrazol-5-yl-thioharnstoffe6a, b. 5a wurde mittels Säure oder Base in das Thioharnstoffderivat8 umgewandelt. Es wird über eine Synthese von 2-Methyl-3-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidin-5-on aus α-Phenylacetoacetonitril (3-Oxo-2-phenyl-butyronitril) und β-Cyanoethylhydrazin berichtet.


Archiv Der Pharmazie | 2015

Cytotoxic and Antimicrobial Evaluations of Novel Apoptotic and Anti‐Angiogenic Spiro Cyclic 2‐Oxindole Derivatives of 2‐Amino‐tetrahydroquinolin‐5‐one

Said Ahmed Soliman Ghozlan; Magda F. Mohamed; Ahmed Gamal Ahmed; Samia A. Shouman; Yasmin M. Attia; Ismail A. Abdelhamid

A novel series of cyclic 2‐oxindole derivatives incorporating 2‐amino‐tetrahydroquinolin‐5‐one were prepared. The structures of the prepared compounds were elucidated using different spectral tools. The regio‐orientation of the reaction products was elucidated through NOE difference experiments and through using substituents on the ortho position to affect further cyclization. Antitumor and antimicrobial evaluations were performed on the prepared compounds. Most of these compounds exhibited high to moderate antimicrobial activity. With respect to the antitumor activity, the compounds showed more potent cytotoxic effect only toward the human breast cancer cell line MCF‐7. Also, we found that derivatives containing an ester group (8c, 11b, 14b, and 15b) are more active than those containing a cyanide group (8a, 11a, 14a, and 15a). Moreover, compounds 15b and 8b are the most active derivatives in this group. These two compounds showed apoptotic inhibition of the proliferation of human breast adenocarcinoma MCF‐7 cells through DNA fragmentation, induction of the tumor suppressor protein p53, induction of caspase‐9, and finally the inhibition of angiogenesis by decreasing vascular endothelial growth factor expression and secretion.


Monatshefte Fur Chemie | 1984

Studies on 5-aminopyrazole derivatives synthesis of some new fused pyrazole derivatives

Ezzat Mohamed Zayed; Said Ahmed Soliman Ghozlan; Abdel-Azim Hady Ibrahim

5-Amino-4-cyano-3-phenylpyrazole (1) reacts with acrylonitrile or ethyl acrylate to yield 4-cyano-3-phenyl-4,5,6,7-tetrahydro-5-oxopyrazolo-[1,5-a]-pyrimidine (2). With urea, thiourea and ethyl acetoacetate1 gives the pyrazolopyrimidine derivatives6a,6b, and7 respectively. On the other hand, compound1 reacted with benzoylisothiocyanate to give the corresponding thiourea derivative4. Diazotized1 was coupled with malononitrile and ethyl cyanoacetate to yield the pyrazolopyrimidine derivatives10 and11, respectively, whereas on coupling with α-chloro acetoacetic ester and with acetylacetone the hydrazones12 and13 were obtained.


Beilstein Journal of Organic Chemistry | 2007

An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues

Said Ahmed Soliman Ghozlan; Khadija O. Badahdah; Ismail A. Abdelhamid

3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively.


Heterocycles | 2016

Synthesis and Antimicrobial Evaluations of Novel Spiro Cyclic 2-Oxindole Derivatives of N-(1H-Pyrazol-5-Yl)-Hexahydroquinoline Derivatives

Amr Mohamed Abdelmoniem; Ismail A. Abdelhamid; Said Ahmed Soliman Ghozlan; Muhammed Ali Ramadan

A novel series of interesting spiro cyclic 2-oxindole derivatives of N-(1H-pyrazol-5-yl)hexahydroquinoline derivatives were prepared via the versatile readily accessible cyclic β-enaminones incorporating pyrazole. Antimicrobial evaluations were performed on the prepared compounds. Most of these compounds exhibited high to moderate antimicrobial activity.


Zeitschrift für Naturforschung B | 1986

Nitriles in Heterocyclic Synthesis: Novel Syntheses of Functionally Substituted Isoxazoles, Pyrazoles, Pyrazines and their Condensed Derivatives

Said Ahmed Soliman Ghozlan; Fatma Abd El Maksoud Abd El Aal; Mona Hassan Mohamed; Mohamed Hilmy Elnagdi

Novel syntheses of functionally substituted isoxazoles, pyrazoles and pyrazines have been reported utilizing ethyl tosyloximinoglyoxalate (1) and the pyridinium salt 2 as starting materials. Functionally substituted nitriles are versatile reagents and their utility in heterocyclic synthesis has received considerable recent attention [3 - 7]. In previous work we have reported several new approaches for the synthesis of azoles, azines and azoloazines utilizing simple readily obtainable polyfunctional nitriles as starting materials [8-12]. Although 1 and 2 can be readily prepared from ethyl cyanoacetate, however, their utility in synthesis of heterocycles has received only very little attention [1, 2, 13-16]


Zeitschrift für Naturforschung B | 1985

4-AryIazo-3,5-diaminoisoxazoIe: Synthesis and Some Chemical Reactions

Ezzat Mohamed Zayed; Said Ahmed Soliman Ghozlan

Abstract Several new isoxazole derivatives were prepared from the newly synthesized 4-arylazo-3,5- diaminoisoxazole


Journal of Heterocyclic Chemistry | 2005

Studies on Enaminonitriles: a New Synthesis of 1,3-Substituted Pyrazole-4-carbonitrile

Said Ahmed Soliman Ghozlan; Ismail A. Abdelhamid; Mohamed Hilmy Elnagdi; Hatem M. Gaber


Tetrahedron | 2009

DBU-Catalyzed, facile and efficient method for synthesis of spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and fused derivatives via [3+3] atom combination

Ismail A. Abdelhamid; Mona Hassan Mohamed; Amr Mohamed Abdelmoniem; Said Ahmed Soliman Ghozlan

Collaboration


Dive into the Said Ahmed Soliman Ghozlan's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge