Adel M. E. Attia

An approach to acyclo-3-deazapyrimidine S-nucleosides via 3,5-dicyano-2(1H)-pyridinethiones

Abstract A series of different acyclo-3-deazapyrimidine nucleosides have been synthesized. The site of glycosylation was confirmed by 13 C NMR spectroscopy.

A New Class of Dihydropyridine Thioglycosides via Piperidinium Salts

Abstract A first reported method for preparation of a new class of thioglycosides via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-α-d-gluco- and galactopyranosyl bromides has been studied. Comparison with the products obtained from silylated thiopyridines is made.

Nucleic acid components and their analogues: new synthesis of bicyclic thiopyrimidine nucleosides.

Abstract A novel synthesis of condensed bicyclic thiopyrimidine glycosides utilising 1H-cyclopentapyrimidine-2(3H)-thiones and α-bromoglucose or α-bromogalactose tetraacetate as starting components is described.

Novel Synthesis of Condensed Pyridinethione Carbocyclic Glycosides

Abstract A novel synthesis of several new condensed pyridinethione carbocyclic glycosides via the reaction of condensed pyridine-2(1H)-thiones with α-halogeno sugars is described.

Synthesis of N 1- and N 3-quinazolin-(3H)- 4-thione non-nucleosides

Quinazolin-(3H)-4-thione non-nucleosides 7, 9 and 12 were obtained by the reaction of quinazolin-(3H)-4-thione 4 with compounds 5, 8 or 10 respectively. The structures of the synthesized non-nucleosides were confirmed by 1H and 13C NMR spectroscopy.

Synthesis of Some New Quinazoline Derivatives Analogues to MKC-442 and TNK 561

A series of different acyclo quinazoline nucleosides 6 , 7 , 8 , 10 , 12 , 13 , and 14 have been synthesized. The site of glycosylation was confirmed by 1 H-NMR and 13 C-NMR spectroscopy.

Synthesis and Antiviral Activity of Some N-Pentopyranosyl-2-Pyridinethiones

Abstract A novel synthesis of 1-(β-D-pentopyranosyl)pyridinethione nucleosides utilizing pyridine-2(1H)-thiones and α-bromoxylose or β-bromoarabinose triacetate as starting components is described. The free nucleosides were tested for their potential activity against HIV and different types of tumor virus.

A facile synthesis of 4-naphthyl-3-cyano-2-(β-d-pyranosylthio) pyridines

The treatment of piperidinium salt of 4-naphthyl-3-cyano-2-thiopyridines with an O -peracetyl-α-D-pyranosyl bromide in dry acetone provides a new and simple method for the synthesis of 2-(β-D-pyranosylthio) pyridines in high yields. The site of glycosylation on the pyridine ring was confirmed by 1 H and 13 C NMR spectral analysis.

Synthesis of novel bicycloalkane ring-fused pyridines via Michael addition reaction of a,ß-Unsaturated Nitriles

Camphorylidene(cyano)thioacetamide (3) and camphorylidenemalononitrile (9) were easily prepared by the reaction of (+)-camphor (1) with cyanothioacetamide (2) and malononitrile (8), respectively, under solid-liquid phase-transfer catalyzed conditions. The reaction of the arylidene derivatives of malononitrile, cyanothioacetamide and cyanoacetamide with 3 and 9 leads to condensed 2-thioxo- and 2-oxo-pyridine derivatives. Treatment of the latter compounds with P4S10 causes transformation into the corresponding pyridinethiones.

A convenient method for the synthesis of 2-(β-D-glycopyranosylthio) pyridines

Abstract Treatment of piperidinium salts of dihydropyridinethiolates 3 with glycosyl bromides 4 in dry acetone provides a convenient and high yielding synthesis of 1,4-dihydro-3-cyanopyridine thioglycosides 5. The structures of 5 were confirmed by oxidation as well as by 1H NMR and 13C NMR spectral analysis.