Galal H. Elgemeie

SYNTHESIS OF SOME NOVEL CONDENSED PYRIDINE-2(1H)-THIONES AND RELATED GLYCOSIDES

Abstract A novel synthesis of condensed pyridine-2(1 H )-thiones and 3-deazapyrimidine glycosides is described utilizing arylmethylenecyanothioacetamides and dimedone as starting components.

SYNTHESIS AND ANTI-HIV ACTIVITY OF DIFFERENT NOVEL NONCLASSICAL NUCLEOSIDES

A series of different novel nonclassical nucleosides have been synthesised and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells.

First Synthesis of Thiophene Thioglycosides

A new method for the preparation of a new class of thiophene thioglycosides via one-pot reaction of the sodium thiophenethiolate salts with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galacto-pyranosyl bromides has been studied. The sodium thiophenethiolate salts are prepared using cyano-di-thioic analogs and their corresponding mono- and dithiolate salts.

New Trends in Synthesis of Pyrazole Nucleosides as New Antimetabolites

Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its α-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.

Potential purine analogue antagonists: Synthesis of novel cycloalkane ring-fused pyrazolo[1,5-a]pyrimidines

ABSTRACT A convenient route for the synthesis of new variety of pyrazolo[1,5-a]pyrimidine derivatives by the reaction of 5-aminopyrazoles with suitable unsaturated keto compounds. The structure of the reaction products were established based on the elemental analysis, spectral data (IR, 1H NMR, MS) and X-ray diffraction analysis.

REACTIONS OF CHLOROCARBONYL ISOCYANATE WITH 5-AMINOPYRAZOLES AND ACTIVE METHYLENE NITRILES: A NOVEL SYNTHESIS OF PYRAZOLO[1,5-a]-1,3,5-TRIAZINES AND BARBITURATES

Reactions of chlorocarbonyl isocyanate and chlorosulfonyl isocyanate with aminopyrazoles and active methylene nitriles are reported. They lead to novel pyrazolo[1,5-a]-1,3,5-triazines and barbituric acid derivatives. The structures of the products and the mechanisms of their formation are reported.

THE DESIGN AND SYNTHESIS OF STRUCTURALLY RELATED MERCAPTOPURINE ANALOGUES: REACTION OF DIMETHYL N-CYANO-DITHIOIMINOCARBONATE WITH 5-AMINOPYRAZOLES

A novel synthesis of 4-methylthiopyrazolo[1,5-a]-1,3,5-triazines via reaction of dimethyl N-cyanodithioiminocarbonate with 5-aminopyrazoles is reported and the synthetic potential of the method is demonstrated.

First Synthesis of Thienopyrazole Thioglycosides

Reported is the first method to prepare a new class of thienopyrazole thioglycosides via a one‐pot reaction of the sodium thienopyrazolthiolate salts with 2,3,4,6‐tetra‐O‐acetyl‐α‐D‐gluco‐and galactopyranosyl bromides. The sodium thienopyrazolthiolate salts are prepared using pyrazoldithioic acids and their corresponding mono ‐ and dithiolate salts.

A New Class of Dihydropyridine Thioglycosides via Piperidinium Salts

Abstract A first reported method for preparation of a new class of thioglycosides via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-α-d-gluco- and galactopyranosyl bromides has been studied. Comparison with the products obtained from silylated thiopyridines is made.

Nucleic acid components and their analogues: new synthesis of bicyclic thiopyrimidine nucleosides.

Abstract A novel synthesis of condensed bicyclic thiopyrimidine glycosides utilising 1H-cyclopentapyrimidine-2(3H)-thiones and α-bromoglucose or α-bromogalactose tetraacetate as starting components is described.