Adelaide de Almeida

Dosimetric parameters for small field sizes using Fricke xylenol gel, thermoluminescent and film dosimeters, and an ionization chamber

Dosimetric measurements in small therapeutic x-ray beam field sizes, such as those used in radiosurgery, that have dimensions comparable to or smaller than the build-up depth, require special care to avoid incorrect interpretation of measurements in regions of high gradients and electronic disequilibrium. These regions occur at the edges of any collimated field, and can extend to the centre of small fields. An inappropriate dosimeter can result in an underestimation, which would lead to an overdose to the patient. We have performed a study of square and circular small field sizes of 6 MV photons using a thermoluminescent dosimeter (TLD), Fricke xylenol gel (FXG) and film dosimeters. PMMA phantoms were employed to measure lateral beam profiles (1 x 1, 3 x 3 and 5 x 5 cm2 for square fields and 1, 2 and 4 cm diameter circular fields), the percentage depth dose, the tissue maximum ratio and the output factor. An ionization chamber (IC) was used for calibration and comparison. Our results demonstrate that high resolution FXG, TLD and film dosimeters agree with each other, and that an ionization chamber, with low lateral resolution, underestimates the absorbed dose. Our results show that, when planning small field radiotherapy, dosimeters with adequate lateral spatial resolution and tissue equivalence are required to provide an accurate basic beam data set to correctly calculate the absorbed dose in regions of electronic disequilibrium.

Relative output factor and beam profile measurements of small radiation fields with an L-alanine/K-Band EPR minidosimeter

The performance of an L-alanine dosimeter with millimeter dimensions was evaluated for dosimetry in small radiation fields. Relative output factor (ROF) measurements were made for 0.5 x 0.5, 1 x 1, 3 x 3, 5 x 5, 10 x 10 cm(2) square fields and for 5-, 10-, 20-, 40-mm-diam circular fields. In beam profile (BP) measurements, only 1 x 1, 3 x 3, 5 x 5 cm2 square fields and 10-, 20-, 40-mm-diam circular fields were used. For square and circular field irradiations, Varian/Clinac 2100, and a Siemens/Mevatron 6 MV linear accelerators were used, respectively. For a batch of 800 L-alanine minidosimeters (miniALAs) the average mass was 4.3+/-0.5 (1 sigma) mg, the diameter was 1.22+/-0.07 (1 sigma) mm, and the length was 3.5+/-0.2 (l sigma) mm. A K-Band (24 GHz) electron paramagnetic resonance (EPR) spectrometer was used for recording the spectrum of irradiated and nonirradiated miniALAs. To evaluate the performance of the miniALAs, their ROF and BP results were compared with those of other types of detectors, such as an ionization chamber (PTW 0.125 cc), a miniTLD (LiF: Mg,Cu,P), and Kodak/X-Omat V radiographic film. Compared to other dosimeters, the ROF results for miniALA show differences of up to 3% for the smallest fields and 7% for the largest ones. These differences were within the miniALA experimental uncertainty (-5-6% at 1 sigma). For BP measurements, the maximum penumbra width difference observed between miniALA and film (10%-90% width) was less than 1 mm for square fields and within 1-2 mm for circular fields. These penumbra width results indicate that the spatial resolution of the miniALA is comparable to that of radiographic film and its dimensions are adequate for the field sizes used in this experiment. The K-Band EPR spectrometer provided adequate sensitivity for assessment of miniALAs with doses of the order of tens of Grays, making this dosimetry system (K-Band/miniALA) a potential candidate for use in radiosurgery dosimetry.

Ferrous Xylenol Gel Measurements for 6 and 10 MV Photons in Small Field Sizes

The Fricke dosimeter is a ferrous sulfate aqueous solution that, when irradiated, oxidizes the Fe2 + ions to Fe3 + . This new concentration, generally determined through spectrophotometry, is directly proportional to the ionizing radiation absorbed energy. The Fricke Xylenol Gel dosimeter (FXG) was developed through the incorporation of swine skin gelatin and xylenol orange. These modifications provided better signal stability and sensitivity for lower absorbed dose measurements, such as those used in radiotherapy. In this work FXG samples were irradiated with absorbed doses of 2 Gy, from 6 MV and 10 MV photons, using small field sizes geometry for dosimetric parameters determination. All the FXG dosimeter readings were accomplished with our specially developed spectrophotometer, using a narrow light beam at the wavelength of 585 nm, where the highest absorbance sensitivity occurs. From our results, we can confirm not only that the FXG dosimetric system (FXG plus a high lateral spatial resolution spectrophotometer) can be used for general dosimetry, but as well for small field size dosimetry of interest in radiosurgery.

Ir-192 HDR transit dose and radial dose function determination using alanine/EPR dosimetry

Source positioning close to the tumour in high dose rate (HDR) brachytherapy is not instantaneous. An increment of dose will be delivered during the movement of the source in the trajectory to its static position. This increment is the transit dose, often not taken into account in brachytherapeutic treatment planning. The transit dose depends on the prescribed dose, number of treatment fractions, velocity and activity of the source. Combining all these factors, the transit dose can be 5% higher than the prescribed absorbed dose value (Sang-Hyun and Muller-Runkel, 1994 Phys. Med. Biol. 39 1181-8, Nath et al 1995 Med. Phys. 22 209-34). However, it cannot exceed this percentage (Nath et al 1995). In this work, we use the alanine-EPR (electron paramagnetic resonance) dosimetric system using analysis of the first derivative of the signal. The transit dose was evaluated for an HDR system and is consistent with that already presented for TLD dosimeters (Bastin et al 1993 Int. J. Radiat. Oncol. Biol. Phys. 26 695-702). Also using the same dosimetric system, the radial dose function, used to evaluate the geometric dose degradation around the source, was determined and its behaviour agrees better with those obtained by Monte Carlo simulations (Nath et al 1995, Williamson and Nath 1991 Med. Phys. 18 434-48, Ballester et al 1997 Med. Phys. 24 1221-8, Ballester et al 2001 Phys. Med. Biol. 46 N79-90) than with TLD measurements (Nath et al 1990 Med. Phys. 17 1032-40).

Fluoropolymer studies for radiation dosymetry

The polymers Tetrafluoroethylene- hexa- fluoropropylene (FEP) and Tetrafluoroethylene- per- fluoromethoxyethelene (PFA) are normally used as anti-adherent coatings and can also be applied for several applications in research. For example, they can be used as radiation dosimeters for X-ray and gamma photons, electrons, protons and other ionazing particles. In order to determine radiation induced damage, that can compromise applications in dosimetry, FEP and PFA films were bombarded with protons of 1 MeV at fluences from 1 × 1011 protons/cm2 to 1 × 1016 protons/cm2. During the bombardment, the chemical species emission was monitored with a Residual Gas Analyzer (RGA), and results show that the CF3 radical is the specie preferentially emitted. The bombarded films were also analyzed with Optical Absorption Photospectrometry (OAP) which shows quantitative chemically specific evidence of the damage caused by the proton bombardment. Our results show that damage to polymers is detectable for all fluences used in this work, but damage that can compromise applications in dosimetry occurs only for fluences greater than 1 × 1014 protons/cm2.

Prevention of Transfusion-Associated Graft-versus-Host Disease by Irradiation: Technical Aspect of a New Ferrous Sulphate Dosimetric System

Irradiation of whole blood and blood components before transfusion is currently the only accepted method to prevent Transfusion-Associated Graft-Versus-Host-Disease (TA-GVHD). However, choosing the appropriate technique to determine the dosimetric parameters associated with blood irradiation remains an issue. We propose a dosimetric system based on the standard Fricke Xylenol Gel (FXG) dosimeter and an appropriate phantom. The modified dosimeter was previously calibrated using a 60Co teletherapy unit and its validation was accomplished with a 137Cs blood irradiator. An ionization chamber, standard FXG, radiochromic film and thermoluminescent dosimeters (TLDs) were used as reference dosimeters to determine the dose response and dose rate of the 60Co unit. The dose distributions in a blood irradiator were determined with the modified FXG, the radiochromic film, and measurements by TLD dosimeters. A linear response for absorbed doses up to 54 Gy was obtained with our system. Additionally, the dose rate uncertainties carried out with gel dosimetry were lower than 5% and differences lower than 4% were noted when the absorbed dose responses were compared with ionization chamber, film and TLDs.

Fricke dosimeter gel measurements of the profiles of shielded fields

In radiation therapy, the shielding of normal tissue can be made using Cerrobend® blocks or a multileaf collimator. In this work, profiles of shielded fields collimated by Cerrobend blocks were obtained through the Fricke Xylenol Gel (FXG) dosimeter irradiated with 6 MV photon beams. The results show that the FXG system can be used in profile measurements of small fields in radiotherapy.

6 MV Wedge Photon Beam Profiles with the Fricke Xylenol Gel Dosimeter

Wedged beam are often used in clinical radiotherapy to compensate missing tissues and dose gradients. In this work, the Fricke Xylenol Gel (FXG) dosimeter was used for 6 MV photons radiation wedge field profiles measurements, allowing to infer the wedge filter physical attenuation coefficient. This dosimeter is a chemical system of a Fe3+-Xylenol complex concentration, that when measured spectrophotometrically, the absorbance is directly proportional to the absorbed dose. From theses results one can infer that the FXG can be used also as an alternative dosimetric system for measurements of wedge filters.

ANÁLISES DE PROTOCOLOS TELETERÁPICOS DE CONTROLE DE QUALIDADE DE ALGUNS SERVIÇOS LOCAIS, BASEADOS NO TG40 E ARCAL XXX

In view of the great importance of quality control in radiotherapy services, this paper aimed primarily to evaluate the tests recommended by international protocols TG40 and ARCAL XXX for teletherapic equipments (cobalt, linear accelerator and simulator). A second objective was to evaluate the tests currently used in some radiotherapy services in Brazil and Latin America and to compare these tests with the ones recommended by the international protocols. Our results suggest that ARCAL is more complete than TG40, although the latter includes all the essential basic tests. We concluded that radiotherapy services should implement all basic quality control tests and that all other complementary tests should be implemented according to the need of each service. Finally, suggestions of protocols are presented, elaborated from the official and routine protocols used.

Análises de protocolos de braquiterapia, por alta taxa de dose, do controle de qualidade de alguns serviços locais, baseados no TG40, TG56 e ARCAL XXX

High dose rate brachytherapy has been increasingly recognized in most countries, and radiotherapy services using this equipment are encouraged to have a very efficient quality assurance program to ensure protection for patients, workers and other personnel involved. The objective of this paper was to determine the types of tests for high dose rate equipment required by official protocols (TG40, TG56 and ARCAL XXX) and to compare them with the types of tests utilized by some radiotherapy services. We concluded that: a) the protocol TG56 is more extensive and complete than the other official protocols (TG40 and ARCAL XXX); b) the protocols used by the services evaluated on this study were based on the protocol TG56, and were concordant with the other official protocols. In these protocols annual tests were frequently replaced by tests performed quarterly or twice a year. This study established the types of test used and their frequency of utilization, and permitted the design of an optimized protocol that may help in the implementation of basic and indispensable tests in order to ensure patient adequate treatment and safety to personnel involved, and consequently improve high dose rate brachytherapy quality assurance.