Lucas Nonato de Oliveira

Dosimetric parameters for small field sizes using Fricke xylenol gel, thermoluminescent and film dosimeters, and an ionization chamber

Dosimetric measurements in small therapeutic x-ray beam field sizes, such as those used in radiosurgery, that have dimensions comparable to or smaller than the build-up depth, require special care to avoid incorrect interpretation of measurements in regions of high gradients and electronic disequilibrium. These regions occur at the edges of any collimated field, and can extend to the centre of small fields. An inappropriate dosimeter can result in an underestimation, which would lead to an overdose to the patient. We have performed a study of square and circular small field sizes of 6 MV photons using a thermoluminescent dosimeter (TLD), Fricke xylenol gel (FXG) and film dosimeters. PMMA phantoms were employed to measure lateral beam profiles (1 x 1, 3 x 3 and 5 x 5 cm2 for square fields and 1, 2 and 4 cm diameter circular fields), the percentage depth dose, the tissue maximum ratio and the output factor. An ionization chamber (IC) was used for calibration and comparison. Our results demonstrate that high resolution FXG, TLD and film dosimeters agree with each other, and that an ionization chamber, with low lateral resolution, underestimates the absorbed dose. Our results show that, when planning small field radiotherapy, dosimeters with adequate lateral spatial resolution and tissue equivalence are required to provide an accurate basic beam data set to correctly calculate the absorbed dose in regions of electronic disequilibrium.

Ferrous Xylenol Gel Measurements for 6 and 10 MV Photons in Small Field Sizes

The Fricke dosimeter is a ferrous sulfate aqueous solution that, when irradiated, oxidizes the Fe2 + ions to Fe3 + . This new concentration, generally determined through spectrophotometry, is directly proportional to the ionizing radiation absorbed energy. The Fricke Xylenol Gel dosimeter (FXG) was developed through the incorporation of swine skin gelatin and xylenol orange. These modifications provided better signal stability and sensitivity for lower absorbed dose measurements, such as those used in radiotherapy. In this work FXG samples were irradiated with absorbed doses of 2 Gy, from 6 MV and 10 MV photons, using small field sizes geometry for dosimetric parameters determination. All the FXG dosimeter readings were accomplished with our specially developed spectrophotometer, using a narrow light beam at the wavelength of 585 nm, where the highest absorbance sensitivity occurs. From our results, we can confirm not only that the FXG dosimetric system (FXG plus a high lateral spatial resolution spectrophotometer) can be used for general dosimetry, but as well for small field size dosimetry of interest in radiosurgery.

Universal zero-bias conductance through a quantum wire side-coupled to a quantum dot

A numerical renormalization-group study of the conductance through a quantum wire side-coupled to a quantum dot is reported. The temperature and the dot-energy dependence of the conductance are examined in the light of a recently derived linear mapping between the Kondo-regime temperature-dependent conductance and the universal function describing the conductance for the symmetric Anderson model of a quantum wire with an embedded quantum dot. Two conduction paths, one traversing the wire, the other a bypass through the quantum dot, are identified. A gate potential applied to the quantum wire is shown to control the flow through the bypass. When the potential favors transport through the wire, the conductance in the Kondo regime rises from nearly zero at low temperatures to nearly ballistic at high temperatures. When it favors the dot, the pattern is reversed: the conductance decays from nearly ballistic to nearly zero. When the fluxes through the two paths are comparable, the conductance is nearly temperature-independent in the Kondo regime, and a Fano antiresonance in the fixed-temperature plot of the conductance as a function of the dot energy signals interference. Throughout the Kondo regime and, at low temperatures, even in the mixed-valence regime, the numerical data are in excellent agreement with the universal mapping.

Fricke dosimeter gel measurements of the profiles of shielded fields

In radiation therapy, the shielding of normal tissue can be made using Cerrobend® blocks or a multileaf collimator. In this work, profiles of shielded fields collimated by Cerrobend blocks were obtained through the Fricke Xylenol Gel (FXG) dosimeter irradiated with 6 MV photon beams. The results show that the FXG system can be used in profile measurements of small fields in radiotherapy.

Universal zero-bias conductance for the single-electron transistor

The thermal dependence of the electrical conductance of the single-electron transistor (SET) in the zero-bias Kondo regime is discussed. An exact mapping to the universal curve for the symmetric Anderson model is established. Linear, the mapping is parametrized by the Kondo temperature and the charge in the Kondo cloud. Illustrative numerical renormalization-group results, in excellent agreement with the mapping, are presented.

Thermal dependence of the zero-bias conductance through a nanostructure

We show that the conductance of a quantum wire side-coupled to a quantum dot, with a gate potential favoring the formation of a dot magnetic moment, is a universal function of the temperature. Universality prevails even if the currents through the dot and the wire interfere. We apply this result to the experimental data of Sato et al. (Phys. Rev. Lett., 95 (2005) 066801).

6 MV Wedge Photon Beam Profiles with the Fricke Xylenol Gel Dosimeter

Wedged beam are often used in clinical radiotherapy to compensate missing tissues and dose gradients. In this work, the Fricke Xylenol Gel (FXG) dosimeter was used for 6 MV photons radiation wedge field profiles measurements, allowing to infer the wedge filter physical attenuation coefficient. This dosimeter is a chemical system of a Fe3+-Xylenol complex concentration, that when measured spectrophotometrically, the absorbance is directly proportional to the absorbed dose. From theses results one can infer that the FXG can be used also as an alternative dosimetric system for measurements of wedge filters.

Measurements of the Fe3+ diffusion coefficient in Fricke Xylenol gel using optical density measurements

In Fricke dosimetry, optical density measurements are performed some time after dosimeter irradiation. Values of the diffusion coefficient of Fe(3+) in Fricke Xylenol gel (FXG) are necessary for determining the spatial distribution of the absorbed dose from measurements of the optical density. Five sets of FXG dosimeters, kept at different constant temperatures, were exposed to collimated 6 MV photons. The optical density profile, proportional to the Fe(3+) concentration, at the boundary between irradiated and non-irradiated parts of each dosimeter was measured periodically over a period of 60 h. By comparing the experimental data with a function that accounts for the unobserved initial concentration profile of Fe(3+) in the FXG, we obtained diffusion coefficients 0.30±0.05, 0.40±0.05, 0.50±0.05, 0.60±0.05 and 0.80±0.05 mm(2)/h for the temperatures 283.0±0.5, 286.0±0.5, 289.0±0.5, 292.0±0.5, and 296.0±0.5 K, respectively. The activation energy of Fe(3+) diffusion in the gel, 0.54±0.06 eV, was determined from the temperature dependence of the diffusion coefficients.

Sensitivity Analysis of Cutting Force on Milling Process using Factorial Experimental Planning and Artificial Neural Networks

This paper aim to investigate and to compare the capabilities of the Artificial Neural Networks (ANN) and the Factorial Experimental Planning (FEP) to measure the most significant variables on milling process that influence the cutting force. The force data were acquired by an experimental apparatus and the statistical inference of the force were set by the Root Mean Squared value. The FEP used the multiple linear regression technics to evaluate the variable significance and then get a model that could predict new responses over designed experiment. On the ANN were applied the Profile Method on a supervised Multilayer Perceptron optimized with the Levenberg-Marquardt algorithm. The results showed good agreement with a confidence level of 90%, that the axial depth of cut, feed per tooth and cutting speed in this order were the most significant variables. This is in accordance with the literature and can open more applications using the ANN approach to obtain a variable significance over other systems.

Universality and the zero-bias conductance of the single-electron transistor

The thermal dependence of the electrical conductance of the single-electron transistor (SET) in the zero-bias Kondo regime is discussed. An exact mapping to the universal curve for the symmetric Anderson model is established. Linear, the mapping is parametrized by the Kondo temperature and the charge in the Kondo cloud. Illustrative numerical renormalization-group results, in excellent agreement with the mapping, are presented.