Adil Boudhas

Giant adrenal hemangioma: Unusual cause of huge abdominal mass

Adrenal hemangioma is an extremely rare benign and non-functioning neoplasm of the adrenal gland. We report a case of a 71-year-old woman admitted for intermittent abdominal pain and abdominal distension associated with vomiting and chronic constipation for 5 years. Physical examination revealed a large abdominal mass. Both computed tomography scan and magnetic resonance imaging suggested hemangioma in the right lobe of the liver. Laboratory examinations and tumour markers were within normal limits, except for hypochromic microcytic anemia. The mass was removed intact by conventional surgery and histopathology revealed a cavernous hemangioma of the adrenal gland with no signs of malignancy. Surgical resection was curative, with no recurrence at the 2-year follow-up.

Expression of human epidermal growth factor receptor 2 in bladder urothelial carcinoma

BackgroundUrothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. Despite many reports in the literature, the prognostic significance of this overexpression remains unclear. The aim of this study was to assess the expression of HER2 in urothelial bladder carcinomas and its association with clinical and pathological parameters.Methods103 cases of UBC were diagnosed in our department between January 2014 and December 2015. The tumor specimens obtained by transurethral resection or cystectomy were evaluated by immunohistochemistry using HER2 antibody.ResultsHER2 protein overexpression was present in 11.7% of cases and associated with tumor grade (p = 0.003) and pathological stage (p = 0.015). In multivariate analysis, HER2 overexpression was associated only with tumor grade (P = 0.04).ConclusionHER2 protein overexpression is noted in patients with high grade cancer. This expression may select patients for anti HER2 targeted therapy. Future larger and prospective studies will verify the frequency of HER2 alteration and the role of HER2 in the aggressive behavior.

Primary Desmoid-Type Fibromatosis of the Mesentery: Report of an Unusual Tumor Localization

Since their initial description in 1832, desmoid tumors have been reported to occur in every part of the body. The mesentery is a very rare localization of this lesion [1, 2]. Mesenteric desmoid-type fibromatosis is under-recognized and often subject to misdiagnosis. It is a locally aggressive mesenchymal neoplasm of the mesentery and adjacent tissues that lacks the capacity to metastasize but shows a high risk of local recurrences. It can occur spontaneously or after surgical trauma. A small percentage of patients are affected byGardner syndrome. Mesenteric desmoid-type fibromatosis (DF) has characteristic morphologic features that are similar to those of fibromatosis elsewhere [1, 3]. This report treats a very rare case of primary giant mesenteric desmoid-type fibromatosis, highlighting clinicopathological features and differential diagnostic problems.

Isolated Neurofibroma of the Sigmoid Colon: a Case Report and Review of the Literature

Neurofibromas are typically benign neoplasms consisting of neural and connective tissue components. These tumors are constantly seen in neurofibromatosis type 1 (NF1, Von Recklinghausen’s disease) andmultiple endocrine neoplasia type 2b (MEN 2b), and have been reported to undergo malignant transformation, with a higher risk when associated with neurofibromatosis. Their occurrence outside the settings of other clinical features of NF1 and MEN 2b is very rare [1], and we ignore if these lesions represent different phenotypic manifestations of NF1 and MEN 2b or whether they represent separate entities.

Inflammatory myofibroblastic tumor of the lacrimal gland: case report of an exceptional location

BackgroundInflammatory myofibroblastic tumour (IMT) is a mesenchymal neoplasm of intermediate biological potential that may affect a wide range of anatomic sites but has a particular predilection for the lung and intra-abdominal soft tissues.Case presentationWe report here an exceptional case of inflammatory myofibroblastic tumor arising in the lacrimal gland and presenting as an orbital mass in a 24-year-old male.ConclusionThis report aims to discuss the importance of histopathological and immunohistochemical findings in arriving at the diagnosis, which helps dictate the management, treatment and prognosis of the patient.

Adenoid cystic carcinoma of the trachea: a clinico-pathological analysis.

Primary malignant tracheal tumors are not common and adenoid cystic carcinoma (ACC) of trachea is very rare. The diagnosis is often delayed due to the atypical symptoms. We report an extremely rare case of ACC of proximal trachea, in a 55-year-old female who presented with a 12 month history of progressive dyspnea. Laryngoscopy and computed tomography revealed a broad-based polypoidal mass arising from posterior wall of the proximal trachea. Biopsy confirmed the diagnosis of ACC. The patient underwent a complete surgical resection and post operative radiotherapy. Six months follow-up of the patient did not reveal local recurrence or distant metastases. The literature of tracheal ACC is reviewed.