Adolph C. Bohnstedt
Princeton University
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Publication
Featured researches published by Adolph C. Bohnstedt.
Bioorganic & Medicinal Chemistry Letters | 2009
Andrew G. Cole; Adolph C. Bohnstedt; Vidyadhar M. Paradkar; Celia Kingsbury; Jorge Quintero; Haengsoon Park; Yingchun Lu; Ming You; Irina Neagu; David J. Diller; Jeffrey J. Letourneau; Yuefei Shao; Ray Anthony James; Christopher Mark Riviello; Koc-Kan Ho; Tsung H. Lin; Bojing Wang; Kenneth C. Appell; Matthew A. Sills; Elizabeth Quadros; Earl F. Kimble; Michael Ohlmeyer; Maria L. Webb
A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was identified incorporating a chroman-based functional group. Compound 24 shows excellent kinase activity, good oral bioavailability and demonstrates efficacy in an acute mechanistic mouse model through inhibition of interleukin-2 (IL-2) induced interferon-gamma (INF-gamma) production.
Archive | 2006
Michael J. Ohlmeyer; Adolph C. Bohnstedt; Celia Kingsbury; Koc-Kan Ho; Jorge Quintero; Ming You; Haengsoon Park; Yingchun Lu
Archive | 2007
Irina Neagu; David J. Diller; Celia Kingsbury; Adolph C. Bohnstedt; Michael J. Ohlmeyer; Vidyadhar M. Paradkar; Nasrin Ansari
Archive | 2007
Gulzar Ahmed; Adolph C. Bohnstedt; Henry J. Breslin; Jason P. Burke; Matthew A. Curry; James L. Diebold; Bruce D. Dorsey; Benjamin J. Dugan; Daming Feng; Diane E. Gingrich; Tao Guo; Koc-Kan Ho; Keith S. Learn; Joseph G. Lisko; Rong-Qiang Liu; Eugen F. Mesaros; Karen L. Milkiewicz; Gregory R. Ott; Jonathan Parrish; Jay Theroff; Tho V. Thieu; Rabindranath Tripathy; Theodore L. Underiner; Jason C. Wagner; Linda Weinberg; Gregory J. Wells; Ming You; Craig A. Zificsak
Archive | 2006
Michael J. Ohlmeyer; Adolph C. Bohnstedt; Celia Kingsbury; Koc-Kan Ho; Jorge Quintero
Archive | 2007
Yingchun Lu; Celia Kingsbury; Adolph C. Bohnstedt; Michael Ohlmeyer; Vidyadhar M. Paradkar
Bioorganic & Medicinal Chemistry Letters | 2006
Koc-Kan Ho; Douglas S. Auld; Adolph C. Bohnstedt; Paolo Conti; Wim Dokter; Shawn David Erickson; Daming Feng; Jim Inglese; Celia Kingsbury; Steven G. Kultgen; Rong-Qiang Liu; Christopher M. Masterson; Michael Ohlmeyer; Yajing Rong; Martijn Rooseboom; Andrew Roughton; Philippe Samama; Martin-Jan Smit; Ellen Son; Jaap van der Louw; G.M.T. Vogel; Maria L. Webb; Jac Wijkmans; Ming You
Archive | 2004
Koc-Kan Ho; John J. Baldwin; Adolph C. Bohnstedt; Steven G. Kultgen; Edward Mcdonald; Tao Guo; John Richard Morphy; Zoran Rankovic; Robert A. Horlick; Kenneth C. Appell
Bioorganic & Medicinal Chemistry Letters | 2004
Koc-Kan Ho; Kenneth C. Appell; John J. Baldwin; Adolph C. Bohnstedt; Guizhen Dong; Tao Guo; Robert A. Horlick; Khondaker R. Islam; Steven G. Kultgen; Christopher M. Masterson; Edward Mcdonald; Kirk McMillan; J.Richard Morphy; Zoran Rankovic; Hardy Sundaram; Maria L. Webb
Archive | 2003
Shawn D. Erickson; John J. Baldwin; Roland E. Dolle; James Inglese; Michael Ohlmeyer; Koc-Kan Ho; Adolph C. Bohnstedt; Steven G. Kultgen; Paolo Giovanni Martino Conti; Dirk Leysen; Jaap van der Louw
