Adrian Zurbuchen
University of Bern
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Annals of Biomedical Engineering | 2013
Aloïs Pfenniger; Magnus Jonsson; Adrian Zurbuchen; Volker M. Koch; Rolf Vogel
Human energy harvesting is envisioned as a remedy to the weight, the size, and the poor energy density of primary batteries in medical implants. The first implant to have necessarily raised the idea of a biological power supply was the pacemaker in the early 1960s. So far, review articles on human energy harvesting have been rather unspecific and no tribute has been given to the early role of the pacemaker and the cardiovascular system in triggering research in the field. The purpose of the present article is to provide an up-to-date review of research efforts targeting the cardiovascular system as an alternative energy source for active medical implants. To this end, a chronological survey of the last 14 most influential publications is proposed. They include experimental and/or theoretical studies based on electromagnetic, piezoelectric, or electrostatic transducers harnessing various forms of energy, such as heart motion, pressure gradients, and blood flow. Technical feasibility does not imply clinical applicability: although most of the reported devices were shown to harvest an interesting amount of energy from a physiological environment, none of them were tested in vivo for a longer period of time.
Europace | 2014
Andreas Haeberlin; Adrian Zurbuchen; Jakob Schaerer; Joerg Wagner; Sébastien Walpen; Christoph Huber; Heinrich Haeberlin; Juerg Fuhrer; Rolf Vogel
AIMS Todays cardiac pacemakers are powered by batteries with limited energy capacity. As the batterys lifetime ends, the pacemaker needs to be replaced. This surgical re-intervention is costly and bears the risk of complications. Thus, a pacemaker without primary batteries is desirable. The goal of this study was to test whether transcutaneous solar light could power a pacemaker. METHODS AND RESULTS We used a three-step approach to investigate the feasibility of sunlight-powered cardiac pacing. First, the harvestable power was estimated. Theoretically, a subcutaneously implanted 1 cm(2) solar module may harvest ∼2500 µW from sunlight (3 mm implantation depth). Secondly, ex vivo measurements were performed with solar cells placed under pig skin flaps exposed to a solar simulator and real sunlight. Ex vivo measurements under real sunlight resulted in a median output power of 4941 µW/cm(2) [interquartile range (IQR) 3767-5598 µW/cm(2), median skin flap thickness 3.0 mm (IQR 2.7-3.3 mm)]. The output power strongly depended on implantation depth (ρSpearman = -0.86, P < 0.001). Finally, a batteryless single-chamber pacemaker powered by a 3.24 cm(2) solar module was implanted in vivo in a pig to measure output power and to pace. In vivo measurements showed a median output power of >3500 µW/cm(2) (skin flap thickness 2.8-3.84 mm). Successful batteryless VVI pacing using a subcutaneously implanted solar module was performed. CONCLUSION Based on our results, we estimate that a few minutes of direct sunlight (irradiating an implanted solar module) allow powering a pacemaker for 24 h using a suitable energy storage. Thus, powering a pacemaker by sunlight is feasible and may be an alternative energy supply for tomorrows pacemakers.
IEEE Transactions on Biomedical Circuits and Systems | 2017
Adrian Zurbuchen; Andreas Haeberlin; Aloïs Pfenniger; Lukas David Bereuter; Jakob Schaerer; Frank Jutzi; Christoph Huber; Juerg Fuhrer; Rolf Vogel
Energy harvesting devices are widely discussed as an alternative power source for todays active implantable medical devices. Repeated battery replacement procedures can be avoided by extending the implants life span, which is the goal of energy harvesting concepts. This reduces the risk of complications for the patient and may even reduce device size. The continuous and powerful contractions of a human heart ideally qualify as a battery substitute. In particular, devices in close proximity to the heart such as pacemakers, defibrillators or bio signal (ECG) recorders would benefit from this alternative energy source. The clockwork of an automatic wristwatch was used to transform the hearts kinetic energy into electrical energy. In order to qualify as a continuous energy supply for the consuming device, the mechanism needs to demonstrate its harvesting capability under various conditions. Several in-vivo recorded heart motions were used as input of a mathematical model to optimize the clockworks original conversion efficiency with respect to myocardial contractions. The resulting design was implemented and tested during in-vitro and in-vivo experiments, which demonstrated the superior sensitivity of the new design for all tested heart motions.
international conference on modelling and simulation | 2013
Adrian Zurbuchen; Aloïs Pfenniger; Sammy Omari; Rolf Vogel
An autonomous energy source within a human body is of key importance in the development of medical implants. This work deals with the modelling and the validation of an energy harvesting device which converts the myocardial contractions into electrical energy. The mechanism consists of a clockwork from a commercially available wrist watch. We developed a physical model which is able to predict the total amount of energy generated when applying an external excitation. For the validation of the model, a custom-made hexapod robot was used to accelerate the harvesting device along a given trajectory. We applied forward kinematics to determine the actual motion experienced by the harvesting device. The motion provides translational as well as rotational motion information for accurate simulations in three-dimensional space. The physical model could be successfully validated.
Therapeutische Umschau | 2015
Andreas Haeberlin; Adrian Zurbuchen; Aloïs Pfenniger; Jürg Fuhrer; Rolf Vogel
Cardiac pacemakers are routinely used for the treatment of bradyarrhythmias. Contemporary pacemakers are reliable and allow for a patient specific programming. However, pacemaker replacements due to battery depletion are common (~25 % of all implantation procedures) and bear the risk of complications. Batteryless pacemakers may allow overcoming this limitation. To power a batteryless pacemaker, a mechanism for intracorporeal energy harvesting is required. Such a generator may consist out of subcutaneously implanted solar cells, transforming the small amount of transcutaneously available light into electrical energy. Alternatively, intravascular turbines may harvest energy from the blood flow. Energy may also be harvested from the ventricular wall motion by a dedicated mechanical clockwork converting motion into electrical energy. All these approaches have successfully been tested in vivo. Pacemaker leads constitute another Achilles heel of contemporary pacemakers. Thus, leadless devices are desired. Miniaturized pacemaker circuits and suitable energy harvesting mechanisms (incorporated in a single device) may allow catheter-based implantation of the pacemaker in the heart. Such miniaturized battery- and leadless pacemakers would combine the advantages of both approaches and overcome major limitations of today’s systems.
Annals of Biomedical Engineering | 2013
Adrian Zurbuchen; Aloïs Pfenniger; Andreas Stahel; Christian T. Stoeck; Stijn Vandenberghe; Volker M. Koch; Rolf Vogel
Annals of Biomedical Engineering | 2017
Lukas David Bereuter; S. Williner; F. Pianezzi; B. Bissig; S. Buecheler; J. Burger; Rolf Vogel; Adrian Zurbuchen; A. Haeberlin
Archive | 2014
Magnus Jonsson; Adrian Zurbuchen; Andreas Haeberlin; Aloïs Pfenniger; Rolf Vogel
Archive | 2014
Adrian Zurbuchen; Andreas Häberlin; Jakob Schärer; Joerg Wagner; Aloïs Pfenniger; Stijn Vandenberghe; Christoph Huber
Archive | 2014
Adrian Zurbuchen; Andreas Häberlin; Jakob Schärer; Aloïs Pfenniger; Rolf Vogel