Adriane Peveling-Oberhag

The Angioedema Quality of Life Questionnaire (AE-QoL) - assessment of sensitivity to change and minimal clinically important difference.

The Angioedema Quality of Life Questionnaire (AE‐QoL) has recently been developed and validated as the first specific patient‐reported outcome tool to assess quality of life (QoL) impairment in recurrent angioedema patients. As of yet, its sensitivity to change and minimal clinically important difference (MCID) have not been established.

Responsiveness and minimal important difference of the urticaria control test

This study demonstrates the responsiveness of the Urticaria Control Test (UCT). Changes of its score by 3 points or more reflect a clinically relevant change of disease control (minimal important difference).

Comparison and Interpretability of the available Urticaria Activity Scores

The urticaria activity score (UAS) is the gold standard for assessing disease activity in patients with chronic spontaneous urticaria (CSU). Two different versions, the UAS7 and UAS7TD, are currently used in clinical trials and routine care. To compare both versions and to obtain data on their interpretability, 130 CSU patients applied both versions and globally rated their disease activity as none, mild, moderate, or severe. UAS7 and UAS7TD values correlated strongly (r = .90, P < .001). Interquartile ranges for UAS7 and UAS7TD values for mild, moderate, and severe CSU were 11‐20 and 10‐24, 16‐30 and 16‐32, and 27‐37 and 28‐40. UAS7 values were slightly, but significantly lower as compared to UAS7TD values (mean difference: 1.6 ± 4.6, P < .001). This difference was driven by lower wheal subscores (2.1 ± 3.5, P < .001) and was most pronounced in patients with severe CSU (2.5 ± 5.6, P < .01). The UAS7/UAS7TD ratio was 0.96 ± 0.21 and did not differ significantly between mild, moderate, and severe CSU. Since the results of both UAS versions are comparable, we recommend the use of the UAS7, which is less burdensome in administration and scoring.

High-Concentration Liquid Prednisolone Formula: Filling a Therapeutic Niche in Severe Acute Attacks of Urticaria and Angioedema

Background/Aims: According to current guidelines, the emergency kit for patients with severe urticaria and/or angioedema should include a corticosteroid with a prednisolone-equivalent of 50-100 mg. Since severe dysphagia may occur in anaphylaxis, liquid corticosteroids are advantageous. Presently, only liquid preparations with less than 100 mg prednisolone equivalent are available worldwide. Methods: We prepared a highly concentrated liquid prednisolone formula for oral administration (1 or 5 mg prednisolone per ml). We observed efficacy and safety of 100 mg or >250 mg liquid oral prednisolone in comparison to intravenous administration (250 mg prednisolone) in 53 patients with urticaria and/or angioedema. Results: The symptom control achieved with oral administration was comparable to that obtained with intravenous therapy, with remission of at least 50% of the symptoms in less than 30 min. No side effects occurred during the treatment period. Conclusion: The liquid prednisolone formula is an additional therapeutic rescue medication in dermatological emergency medicine, filling a therapeutic niche for patients who need high-concentration liquid prednisolone. It is suitable for self-administration emergency kits in children and adults, in accordance with current guidelines.

Dermatologische Rezepturen in Deutschland - Relevanz für die Versorgung: Rezepturen in Deutschland

Rezepturen sind Verordnungsoptionen, die die Patientenversorgung besonders in der topischen Therapie sinnvoll ergänzen und damit optimieren. Bedingt durch die letzte Apothekenbetriebsordnung (2012) ergaben sich Änderungen in der Verschreibungs‐ sowie Herstellungspraxis. Zielsetzung dieser Untersuchung ist es, die Relevanz von Rezepturen im aktuellen klinischen Alltag in Deutschland zu ermitteln.

Extemporaneous formulations in Germany - relevance for everyday clinical practice: Extemporaneous formulations in Germany

Extemporaneous formulations broaden the spectrum of therapeutic options for topical treatment in particular and thus improve patient care. The latest amendment to the Regulation on the Operation of Pharmacies issued in 2012 brought about changes in prescribing and manufacturing practices. The aim of the present study was to assess the relevance of extemporaneous formulations in everyday clinical practice.

Eine Erkrankung in allen Lebenslagen

Die Urtikaria ist in der Regel einfach zu diagnostizieren, für den Patienten kann sie jedoch eine hohe Krankheitslast bedeuten. Ziel jeder Behandlung ist es, die Symptome zu kontrollieren und die Triggerfaktoren zu eliminieren.