Aeysha Sultan

Evaluation of Silica-H2SO4 as an Efficient Heterogeneous Catalyst for the Synthesis of Chalcones

We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.

Steroids: A Diverse Class of Secondary Metabolites

Steroidsform a group of secondary metabolites having diversity in their structure and biological functions. These natural products, although often linked with the deleterious effect on health, have many medicinal applications and the research is still continued in search of these secondary metabolites as potential lead in drug design/discovery. The Aim of this review is to systematically compile the basic information related to this class of natural products.

Free Radical–Mediated Chemoselective Reduction of Enones

Abstract A novel methodology has been devised for the chemoselective reduction of enones involving the use of n Bu3SnH and azobisisobutyronitrile. The 1,4-reduction of variously substituted α,β-unsaturated cyclic and acyclic enones has been successfully carried out under free radical reaction conditions. The reaction has been determined to proceed via single-electron transfer. [Supplementary materials are available for this article. Go to the publishers online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] GRAPHICAL ABSTRACT

Allopathy Versus Homeopathy: A Never Ending Tacit War

Copyright:

Comparison of Medicinally Important Natural Products versus Synthetic Drugs-A Short Commentary

Nature as inspired human beings since time immemorial and every member of human race, irrespective of origin and religion, keeps nature at an esteemed place. It is a common belief that everything that occurs in nature has beneficial effects as compared to products of anthropogenic origin. The medical profession is as old as the human history and so is the history of medicines. In current era, with advancement in medical science, the intensity of diseases has also increased. New medicines are being developed for the treatment of complicated diseases but these medicines are themselves associated with a number of side effects that range from minor to sever intensity. The medicines from nature on the other hand appear to be more effective than the synthetic counter-part. This short commentary deals with comparison of synthetic drugs and the drugs from nature with special emphasis on extent of side effects associated with both categories.

PASSIVE ATTITUDE OF STUDENTS IN A CLASS ROOM SETTING – ARE TEACHERS THE REAL CULPRITS?

Aeysha Sultan 1 and Bukhtawar Sultan 2 . 1. Department of Chemistry, University of Education Lahore, Faisalabad Campus, Faislabad-38000, Pakistan. 2. Department of Chemistry, University of Sargodha, Sargodha-40100, Pakistan. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History

Fragmentation Study of Substituted Chalcones: Gas Phase Formation ofBenz-1-oxin Cation

The mass spectra of a number of substituted chalcones have been observed to show intense M - X peaks (where X=Cl, Br, OH, OMe), which largely arise through the loss of an ortho-substituent from the ring-A of chalcones. The base peak is attributed to highly resonance stabilized benz-1-oxin cation, which would be formed via modified McLafferty rearrangement in gas phase (70 eV). The exact mass measurement of such fragments and DFT studies supports the formation and stability of benz-1-oxin cation. This protocol may also be conveniently used to distinguish among different positional isomers of substituted chalcones.

Efficient Synthesis of 3-Aryl-5-chloroindan-1-ones via Free Radical–Mediated Intramolecular Cyclization

Abstract An efficient free radical–mediated intramolecular cyclization strategy has been developed for the synthesis of 3-aryl-5-chloroindan-1-ones. Variously substituted 2,4-dichloroenones afforded 3-aryl-5-chloroindan-1-ones in quantitative yields upon intramolecular cyclization under free radical conditions. GRAPHICAL ABSTRACT

2,4-Dibromo-naphthalen-1-ol.

In the essentially planar (r.m.s. deviation = 0.023 Å) title compound, C10H6Br2O, an intramolecular O—H⋯Br hydrogen bond generates an S(5) ring. In the crystal, molecules are linked by an ⋯O—H⋯O—H⋯O— C(2) chain extending along [100], which involves the same H atom that participates in the intramolecular hydrogen bond. Aromatic π–π interactions [centroid–centroid separation = 3.737 (4) Å] help to consolidate the packing.

4-Hy­droxy-2-methyl-3,4-diphenyl­cyclo­pent-2-en-1-one

The asymmetric unit of title compound, C18H16O2, contains two molecules with slightly different conformations. In the first molecule, the two phenyl rings make dihedral angles of 84.98 (11)° and the five-membered ring makes dihedral angles of 84.80 (12) and 73.00 (12)° with the phenyl rings; the corresponding angles for the second molecule are 86.74 (11), 81.20 (13) and 71.36 (12)°. O—H⋯O hydrogen bonds between the hydroxy and carbonyl groups are a feature of the crystal packing, which results in chains extending parallel to [100]. Weak C—H⋯O and C—H⋯π interactions are also observed.