Afgan Farooq

Essential oil constituents of the spice Cinnamomum tamala (Ham.) Nees & Eberm.

Water-distilled essential oil of Cinnamomum tamala (Ham.) Nees & Eberm. (Lauraceae) leaves was analysed by GC – MS. Sixty-three compounds, representing 94.3% of the oil, were identified. β-Caryophyllene (25.3%), linalool (13.4%) and caryophyllene oxide (10.3%) were the main constituents of the oil obtained in 0.03% yield. Copyright

Fungal Transformations of Steroids by Cephalosporium Aphidicola and Trichothecium Roseum

Abstract Transformation of dehydroepiandrosterone (1) was carried out by incubation with the fungus Cephalosporium aphidicola to obtain 3β-hydroxyandrost-4-en-17-one (2) and 3β,4β-dihydroxyandrost-5-en-17-one (3). The fermentation of androsterone (4) by Trichothecium roseum afforded 3α, 17β-dihydroxyandrostane (5).

Microbial transformation of sarsasapogenin by Fusarium lini

The fermentation of sarsasapogenin with Fusarium lini yielded two metabolites identified as 3β-acetoxysarsasapogenin and 7α-hydroxysarsasapogenin. The metabolites showed dose dependent spasmolytic activity in rat duodenum.

Microbial Transformations of Testosterone

Abstract Microbial transformation of testosterone (17β-hydroxyandrost-4-en-3-one) (1) by Curvularia lunata and Pleurotus oestreatus yielded 17-dehydrotestosterone (androst-4-ene-3,17-dione) (2) and 15α-hydroxytestosterone (15α, 17β-dihydroxyandrost-4-en-3- one) (3), respectively.

The Microbial Oxidation of (–)-β-Pinene by Botrytis cinerea

(-)-β-pinene, a flavor and fragrance monoterpene is an important constituent of essential oils of many aromatic plants. It was oxidized by a plant-pathogenic fungus, Botrytis cinerea to afford four metabolites characterized as (-)-6α-hydroxy-β-pinene, (-)-4β,5β-dihydroxy- β-pinene, (-)-2β,3β-dihydroxypinane, and (-)-4β-hydroxy-β-pinene-6-one by detailed spectroscopic studies along with other known metabolites.

Biotransformation Of (–)-α-Pinene By Botrytis Cinerea

(-)-α-Pinene (1), a major constituent of many aromatic plants was biotransformed by the plant pathogenic fungus, Botrytis cinerea to afford three new metabolites, characterized as 3 β-hydroxy-(-)- β-pinene (10%) (3), 9-hydroxy-(-)-α-pinene (12%) (4), 4 β-hydroxy-(-)-α- pinene-6-one (16%) (5) by physical and spectroscopic methods. A known metabolite verbenone (2) was also obtained

Phytochemical Studies on Steroidal Alkaloids of Sarcococca saligna

Abstract Three new pregnane-type steroidal alkaloids salignenamide-A 1 [(20S, 2′Z) - 20 - (N,N - dimethylamino) - 3β - (3′, 4′ - dimethyl-2-pentenamido)-pregnane], salignenamide-B 2 [(20S,2′Z)-20- (N,N-dimethylamino)-3β-(3′-methyl-2′-butenamido)-pregna-4, 14-diene] and 2,4-diacetoxyepipachysamine-D 3 [(20S)-20-(N,N-dimethylamino)-3β-benzamido-2β, 4β-diacetoxypregnane] have been isolated from the ethanolic extracts of the whole plant of Sarcococca saligna. The structures of these steroidal alkaloids were established on the basis of detailed spectroscopic studies.

MICROBIAL TRANSFORMATION OF SOME BIOACTIVE NATURAL PRODUCTS

Abstract The microbial transformation of vindoline (1) by Aspergillus niger, Fusarium lini and F. monolinum afforded 17-deacetylvindoline (2) as the sole metabolic product, whereas α-santonin (3) was regiospecifically reduced to 1,2-dihydro-α-santonin (4) by Aspergillus niger.