Ágnes Filep

Respiratory consequences of red sludge dust inhalation in rats

The environmental disaster following flooding by red sludge in the Ajka region in Hungary poses a serious public health threat with particular concern regarding the potentially adverse respiratory effects of the inhalation of red sludge dust (RSD). The respiratory consequences of the inhalation of RSD obtained from field samples were investigated in rats. Rats were either exposed to RSD at a high concentration (2 weeks, 8h/day), or kept in room air. After the exposures, the airway resistance (R(aw)) and the respiratory tissues mechanics were measured under baseline condition, and following methacholine (MCh) challenges with the aim of establishing airway hyper-responsiveness (AH). Histopathology was performed to assess lung morphologic alterations. The physical properties and the chemical composition of the RSD were also characterized. The size distribution, chemical composition and topology of the RSD particles applied in our experiments were similar to those observed at the site of the disaster. The inhalation of RSD did not alter the basal respiratory mechanics, whereas it led to greater MCh-induced responses in R(aw), demonstrating the progression of mild AH. Histopathological investigations revealed fine, granular particles in the alveolar macrophages, as evidence that RSD had reached the lower respiratory tract and induced mild inflammation around the alveoli and the pulmonary vasculature. The mild respiratory symptoms that developed following short-term exposure of healthy individuals to high concentrations of airborne RSD do not appear to pose a greater respiratory hazard than the inhalation of urban dust at a comparable concentration.

The filter loading effect by ambient aerosols in filter absorption photometers depends on the mixing state of the sampled particles

[1] Research and Development Department, Aerosol d.o.o., Ljubljana, Slovenia [2] Condensed Matter Physics Department, Jožef Stefan Institute, Ljubljana, Slovenia 10 [3] Center for Atmospheric Research, University of Nova Gorica, Nova Gorica, Slovenia [4] Laboratory of Atmospheric Chemistry, Paul Scherrer Institute (PSI), 5232 Villigen PSI, Switzerland [5] Institut National de l’Environnement Industriel et des Risques, Verneuil-en-Halatte, France [6 ]Laboratoire des Sciences du Climat et de l’Environnement (CNRS-CEA-UVSQ), CEA Orme des Merisiers, Gif-sur-Yvette, France 15 [7] Energy Environment and Water Research Center,The Cyprus Institute, Nicosia, Cyprus [8] Desert Research Institute, Nevada System of Higher Education, Reno, USA [9] MTA-SZTE Research Group on Photoacoustic Spectroscopy, Department of Optics and Quantum Electronics, University of Szeged, Szeged, Hungary [#] now at: Lucerne University of Applied Sciences and Arts, School of Engineering and Architecture, 20 Bioenergy Research, Horw, Switzerland [

A novel multi−wavelength photoacoustic spectrometer for the measurement of the UV–vis-NIR spectral absorption coefficient of atmospheric aerosols

] now at: Air Lorraine, Metz, France [+] now at: Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA [%] now at: College of Optical Sciences, University of Arizona, Tucson, AZ, USA 25