Tibor Ajtai

Respiratory consequences of red sludge dust inhalation in rats

The environmental disaster following flooding by red sludge in the Ajka region in Hungary poses a serious public health threat with particular concern regarding the potentially adverse respiratory effects of the inhalation of red sludge dust (RSD). The respiratory consequences of the inhalation of RSD obtained from field samples were investigated in rats. Rats were either exposed to RSD at a high concentration (2 weeks, 8h/day), or kept in room air. After the exposures, the airway resistance (R(aw)) and the respiratory tissues mechanics were measured under baseline condition, and following methacholine (MCh) challenges with the aim of establishing airway hyper-responsiveness (AH). Histopathology was performed to assess lung morphologic alterations. The physical properties and the chemical composition of the RSD were also characterized. The size distribution, chemical composition and topology of the RSD particles applied in our experiments were similar to those observed at the site of the disaster. The inhalation of RSD did not alter the basal respiratory mechanics, whereas it led to greater MCh-induced responses in R(aw), demonstrating the progression of mild AH. Histopathological investigations revealed fine, granular particles in the alveolar macrophages, as evidence that RSD had reached the lower respiratory tract and induced mild inflammation around the alveoli and the pulmonary vasculature. The mild respiratory symptoms that developed following short-term exposure of healthy individuals to high concentrations of airborne RSD do not appear to pose a greater respiratory hazard than the inhalation of urban dust at a comparable concentration.

Photoacoustic detection based permeation measurements: Case study for separation of the instrument response from the measured physical process

In a carrier flow based permeation system the measured permeation curve is the convolution of two processes: the intrinsic permeation process and the transfer of the permeated molecules through the measuring system. The latter one is quantified by the instrument response function (IRF). The possibility of calculating the IRF from permeation curves measured at various volumetric flow rates of the carrier gas is examined. The results are in partial agreement with preliminary expectations: the dependency of the calculated IRF on the volumetric flow rate of the carrier gas indeed follows roughly the expected tendency; however it is not completely independent from the physical properties of the measured membrane sample. This discrepancy can most probably be attributed to the imperfect design of the applied permeation cell. Overall it is expected that the proposed method for determining the instrument transfer function is a valuable tool for improving the design of permeation measuring systems.