Agnieszka Cwik

A simple synthesis of 2-substituted oxazolines and oxazines

Abstract β-Aminoalcohols react with carboxylic acids in the presence of a zeolite, Ersorb-4, resulting in the formation of oxazoline derivatives in good yields. Similarly, 3-aminopropanol and benzoic acid gave the corresponding 2-phenyloxazine.

Microwave-assisted conversion of oximes into nitriles in the presence of a zeolite

Aromatic aldoximes were converted to the corresponding nitriles in a microwave oven in the presence of a molecular sieve-type modified zeolite, Ersorb, under solvent-free conditions. The yields depended on the substituent of the oxime.

Mg-Al 3:1 hydrotalcite catalyst in the synthesis of cyclopropane carboxylic acid derivatives

Abstract The non-activated Mg-Al 3:1 hydrotalcite is a suitable basic catalyst both in the intramolecular cyclization reaction of malonic acid allylic esters into bicyclic cyclopropane carboxylic acid lactones and the intermolecular cyclization reaction of dibromoethane and diethyl malonate into cyclopropane dicarboxylic acid diester. The optimal reaction conditions of the intramolecular cyclization were determined using a 2 4 factorial design. An interesting effect on the diastereoselectivity of the intramolecular cyclization was observed compared with the diastereoselectivity of this cyclization using solid potassium carbonate as base.

A new and convenient method for the acylation of amino acids in the presence of a modified zeolite: Ersorb®

Reaction of free amino acids with acid chlorides in dioxane in the presence of a modified zeolite-type mineral Ersorb-4 results in the formation of the appropriate N-acyl derivatives. High yields were obtained with aryl chlorides, poorer with aliphatic ones.

Catalytic Transfer Hydrogenation and Hydrogenolysis in Ionic Liquids with Pd/MgLa Mixed Oxide and Pd/MgAl Hydrotalcite as Recyclable Catalysts

Abstract A new Pd/MgLa mixed oxide and the known Pd/MgAl hydrotalcite catalysts were applied and recycled successfully in catalytic transfer hydrogenation reactions in ionic liquids. Some α,β‐unsaturated carboxylic acid derivatives were hydrogenated in excellent yields. The catalysts were recycled without significant loss of activity. Besides that, a number of halogenated aromatic compounds were dehalogenated under similar catalytic transfer conditions.

A simple synthesis of 1,1,2-tris-(hydroxymethyl)-cyclopropane and its dihalo derivatives

The phase transfer catalytic cyclopropanation of the malonic ester of allylic alcohol or its 3,3-dibromo and 3,3-dichloro derivatives yields bicyclic cyclopropane carboxylic acid lactones; reduction of these lactones with LiAlH4 in boiling THF yields the appropriate 1,1,2-tris-(hydroxymethyl)cyclopropanes in satisfactory yield.