Ahmet Rıfat Örmeci

The effects of chelators on zinc levels in patients with thalassemia major.

Zinc which is an essential element has very important effects on growth and immune system in patients with thalassemia major (TM). The effects of two oral iron chelator agents, desferrioxamine (DFO) and deferiprone (DFP), on zinc levels were investigated in previous studies and they were found to cause zinc deficiency. Zinc level alteration by the new chelator deferasirox (DFX) is not present in the literature. The aim of this study was to examine the effects of different oral chelators on serum and urine zinc levels in TM patients. Zinc levels are compared in the patients who received different chelators: only DFX, combined chelation with DFO plus DFP and the healthy control group. A total of 56 patients with TM were involved in this study: 39 patients received only DFX and 17 patients were given combined treatment DFO+DFP between August 2008 and August 2009. In addition, a control group was established from the healthy population. Blood was taken from all the patients for serum zinc levels and 24hour-urine samples were collected for urine zinc levels. Serum zinc levels were found to be 64.8±14.8μg/dL in DFX group and 66.5±15.1μg/dL in DFO+DFP group. These levels were statistically lower than that in the control group (149±54.3μg/dL) (p<0.05), but there was no statistically difference between the two different chelation groups (p>0.05). The urine zinc levels of DFX and DFO+DFP group were 662.2±428.2μg/day and 1182.3±980.3μg/day respectively (p<0.05). Urinary zinc excretion in the chelation groups (DFX and DFO+DFP) was significantly higher than the control group (395.1±208.9μg/day) (p<0.05). As a conclusion, the new chelation agent, DFX, also leads to zinc deficiency, though its urinary zinc excretion is lower. New studies are required to examine the effects of DFX on zinc extensively. Zinc levels of patients with TM should be followed up regularly and zinc supply should be given at early ages.

Effects of long-term pre- and post-natal exposure to 2.45 GHz wireless devices on developing male rat kidney

Abstract Purpose The aim of the present study was to investigate oxidative stress and apoptosis in kidney tissues of male Wistar rats that pre- and postnatally exposed to wireless electromagnetic field (EMF) with an internet frequency of 2.45 GHz for a long time. Methods The study was conducted in three groups of rats which were pre-natal, post-natal. and sham exposed groups. Oxidative stress markers and histological evaluation of kidney tissues were studied. Results Renal tissue malondialdehyde (MDA) and total oxidant (TOS) levels of pre-natal group were high and total antioxidant (TAS) and superoxide dismutase (SOD) levels were low. Spot urine NAG/creatinine ratio was significantly higher in pre- and post-natal groups (p < 0.001). Tubular injury was detected in most of the specimens in post-natal groups. Immunohistochemical analysis showed low-intensity staining with Bax in cortex, high-intensity staining with Bcl-2 in cortical and medullar areas of pre-natal group (p values, 0.000, 0.002, 0.000, respectively) when compared with sham group. Bcl2/Bax staining intensity ratios of medullar and cortical area was higher in pre-natal group than sham group (p = 0.018, p = 0.011). Conclusion Based on this study, it is thought that chronic pre- and post-natal period exposure to wireless internet frequency of EMF may cause chronic kidney damages; staying away from EMF source in especially pregnancy and early childhood period may reduce negative effects of exposure on kidney.

EFFECTS OF A FORMAL TRAINING PROGRAMME ON CONSANGUINEOUS MARRIAGES ON HIGH SCHOOL STUDENTS' KNOWLEDGE AND ATTITUDES: AN INTERVENTIONAL STUDY FROM TURKEY

Consanguineous marriage is traditionally common throughout the eastern Mediterranean region. Research has suggested that it is closely linked to the sociocultural and socioeconomical status of individuals, and education plays a critical role in decreasing the number of cases. This study aimed to determine the effects of a formal training programme on consanguineous marriages on the knowledge of, and attitudes towards, consanguineous marriage of high school students (n=804) in the Mediterranean region of Turkey. Seniors from three randomly selected public high schools participated in the pre-test and post-test design study. To determine the effects of the programme, students who received the training were compared with those who did not receive any formal training about the subject. After the post-tests were administered, data were collected and analysed using chi-squared and McNemar tests. The results showed significant differences in knowledge and attitudes among the students who had received the formal training programme and those who had not. In addition, the results indicated potential peer influence between the students who received training in consanguineous marriage and those who did not.

Unilateral Renal Vein Thrombosis and Adrenal Hemorrhage in A Newborn with Homozygous Factor V Leiden and Heterozygous Of MTHFR-677T, MTHFR-1298C Gene Mutations.

Renal vein thrombosis (RVT) occurs as an acute and life-threatening event in neonates. RVT is the most common non–catheter-related thrombosis in infancy and occurs primarily in the newborn period. Non-catheter-related abdominal thrombosis on neonates has a higher incidence of genetic prothrombotic risk factors. RVT and adrenal hemorrhage can both be encountered in the neonatal period and they may occur at the same time (Bokenkamp et al., Eur J Pediatr 159:44–8, 2000; Lau et al. Pediatrics 120:1278–84, 2007). We report a case of unilateral RVT and adrenal hemorrhage in a newborn with homozygous factor V Leiden mutation and heterozygous of the methylene tetrahydrofolate reductase (MTHFR) gene mutations.

Ön Fontanel Boyutları ve Kapanma Zamanı

Bu calisma Isparta yoresindeki saglikli cocuklarda normal fontanel boyutlarini ve kapanma zamanlarini saptamak amaciyla yapildi Calisma kapsamina alinan ve yaslari bes gun ile 20 ay arasinda degisen 1252 cocugun 611 kiz 641 erkek on fontanel boyutlari bas cevresi vucut agirligi ve boy olcum degerleri belirlendi Yenidogan doneminde on fontanel capinin ortalama degeri 31 5±1 mm altinci ayda 19±1 mm bulundu On fontanelin kapanma orani 12 aylik cocuklarda 42 5 16 aylik cocuklarda 85 18 aylik cocuklarda ise 90 8 olarak bulundu Fontanel boyutlari ve kapanma zamanlari bakimindan her iki cins arasinda istatistiksel olarak anlamli fark yoktu Anahtar kelimeler: Anterior Fontanelle Size And Closure Time

Çocukluk Çağında Hematüri ve Tanısal Yaklaşım

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1996 Mart; 3(1) Cocukluk Caginda Hematuri ve Tanisal Yaklasim Ali Ayata Faruk Oktem Hasan Cetin Ahmet R. Ormeci Gulderen Ozeren Ozet Makroskopik (gros) veya mikroskopik olabilen hematittiler glonieruler veya ekstraglomeruler bozukluklara bagli gelisebilir ve bir idrar tetkikiyle orijinin saptanmasi genellikle mumkundur. Ilk olarak stikle saptanilan hematurilerin, ayrica dikkatli bir mikroskopik muayeneyle dogrulanmasi gerekir. Yenidoganlarda hematim oncelikle hipoksi, tromboz, dolasim bozuklugu gibi vaskuler kaynakli olurken daha buyuk cocuklarda hayta uriner enfeksiyonlar olmak uzere glomerulonefritler ve travmalara bagli olarak gelismektedir. Hiperkalsiuri ve nefroUtiyazis de hematuriye neden olabilir. Anahtar Kelimeler: Hematuri, tantsalyaklasim. Abstract Diagnostic Approach for Heniaturia in Childhood Heniaturia may be grosa or microscopic. it can resiilt from glomerular or extraglomerular pathology, which can often be clinically distitiguished by urinalysis. Initial detection of hematuria, usually by dipstick but at times by the appearance ofthe itrine, should be followed by confirmation with careful microscopic aiuilysis. Hematuria in newborns results primarlyfrom vascular disorders such as hypoxia, thrombosis, or circulatory compromise; in older children, urinary tract infections accountfor the majority of cases, follovved by glomeritlonephritis and trauma. Hypercalciuria and nephroUthiasis also can cause hematuria. Key Words: Hematuria, diagnostic approach.

Bakteriyel Menenjitli Çocuklarda Deksametazon Tedavisi

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1996 Haziran; 3(2) Bakteriyel Menenjitli Cocuklarda Deksametazon Tedavisi Faruk Oktem Ali Ayata Hasan Cetin Ahmet Rifat Ormeci Ozet Bakteriyel menenjiti! cocuklarda deksametazon kullaniminin, meningeal inflamasyonu onleyerek odiyolojik ve norolojik sekelleri azalttigi gosterilmistir. Bu tedavinin avantajlari, ozellikle ilk antibiyotik dozundan once verilirse, dezavantajlarindan daha fazladir. Anahtar Kelimeler: Bakteriyel menenjit, deksametazon tedavisi Abstract Dexamethasone Therapy for Children with Bacterial Meningitis Dexamethasone therapy in children vvith bacterial meningitis is recorded to reduce hearing loss and other neurologic seguelae by preventing meningeal inflammation. The advantages of dexamethasone treatment, especially when given before the first parenterally administered antibiotic dose, clearly outweigh thepossible dis advantages. Key Words: Bacterial meningitis, dexamethasone therapy