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Akihiko Hosoda

University of Tokyo

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Tetrahedron Letters | 1987

Highly cis-selective Wittig reaction of oxido-allylic phosphorane with aldehyde. An efficient synthesis of 11-cis-retinoids

Akihiko Hosoda; Takeo Taguchi; Yoshiro Kobayashi

Abstract An efficient and higly stereoselective preparation of (2E,4Z)-dienyl alcohols was explored by reactions of (E)-oxido-allylic phosphorane with aldehydes. 11-cis-Retinals could be effectively prepared.

Tetrahedron Letters | 1985

Synthesis of(7e,9e,11e,13e)-18,18,18-trifluororetinal (all-trans 5-trifluoromethylretinal)

Takeo Taguchi; Akihiko Hosoda; Yoshiro Kobayashi

Abstract All-trans-18,18,18-trifluororetinal (2) was synthesized through trifluorocyclocitral (3) as a key intermediate.

Tetrahedron Letters | 1988

Preparation of 2-trifluoromethylvitamin K analogs

Takeo Taguchi; Yoshimitsu Suda; Akihiko Hosoda; Yoshiro Kobayashi

Abstract 2-Trifluoromethylvitamin K analogs( 6 ) were efficiently prepared through allylation of the MOM ether( 4 ) followed by oxidation.

Archive | 1992

Aldehyde derivatives and their use as calpain inhibitors

Akihiko Hosoda; Yukihide Nakayama; Masahiro Shibata; Yasuo Sekine; Niro Inaba; Hiroshi Ikawa; Tetsuaki Yamaura; Naoko Tanabe

Archive | 1991

Acyl derivative having enzyme-inhibiting action

Akihiko Hosoda; Jiro Inaba; Takahide Nakayama; Yasuo Sekine; Masahiro Shibata; Kazuhiko Takasaki; Naoko Tanabe

Chemical & Pharmaceutical Bulletin | 1987

THE DIELS-ALDER REACTION OF 1-PHENYLSULFONYL-3, 3, 3-TRIFLUOROPROPENE

Takeo Taguchi; Akihiko Hosoda; Ginjiro Tomizawa; Akihiro Kawara; Toshio Masuo; Yoshimitsu Suda; Masaharu Nakajima; Yoshiro Kobayashi

Journal of the American Chemical Society | 1986

5-(Trifluoromethyl)bacteriorhodopsin does not translocate protons.

V. Jayathirtha Rao; Fadila Derguini; Koji Nakanishi; Takeo Taguchi; Akihiko Hosoda; Yuji Hanzawa; Yoshiro Kobayashi; Chandra M. Pande; Robert Callender

Archive | 1999

Cyclic amide derivatives which inhibit cathepsin K

Masaharu Dozen; Akihiko Hosoda; Nobuo Kobayashi; Tsuneo Koji; Akihiro Sekine; Masahiro Shibata; Naoko Tanabe

Chemical & Pharmaceutical Bulletin | 1998

A novel histamine 2(H2) receptor antagonist with gastroprotective activity. II. Synthesis and pharmacological evaluation of 2-furfuryl-thio and 2-furfurylsulfinyl acetamide derivatives with heteroaromatic rings.

Nobuhiko Hirakawa; Hajime Matsumoto; Akihiko Hosoda; Akihiro Sekine; Tetsuaki Yamaura; Yasuo Sekine

Archive | 2002

Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing alpha-keto amide compound using them

Nobuo Kobayashi; Tsuneo Koji; Takashi Fujita; Tomofumi Nishimura; Akihiko Hosoda

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Yasuo Sekine

Hokkaido University

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Akihiro Sekine

Toho University

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Hajime Matsumoto

National Institute of Advanced Industrial Science and Technology

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Masahiro Shibata

Shibaura Institute of Technology

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Hiroshi Ikawa

Toho University

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Takeo Taguchi

Tokyo University of Pharmacy and Life Sciences

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Yoshiro Kobayashi

Toho University

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Masakatsu Matsumoto

Kanagawa University

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Masato Nishimura

University of Tokushima

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Noriaki Kashiwaba

Kanazawa University

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