Akira Maruyama
Mitsubishi
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Publication
Featured researches published by Akira Maruyama.
Biochemical and Biophysical Research Communications | 1981
Shosuke Okamoto; Akiko Hijikata; Ryoji Kikumoto; Shinji Tonomura; Hiroto Hara; Kunihiro Ninomiya; Akira Maruyama; Mamoru Sugano; Yoshikuni Tamao
Abstract Four stereoisomers of 4-methyl-1-[N 2 -(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid were synthesized and examined for the inhibitory effect on thrombin. The inhibitory potency varied largely with the stereo-configuration of the 4-methyl-2-piperidinecarboxylic acid portion. The (2R, 4R)-isomer was the most potent inhibitor with a Ki of 0.019 μM, while the (2R, 4S) and (2S, 4R)-isomers showed the values of Ki 0.24 and 1.9 μM, respectively. The least potent inhibitor, (2S, 4S)-isomer, showed a Ki of 280 μM which is approximately 15,000 times that of (2R, 4R)-isomer.
Journal of Medicinal Chemistry | 1991
Hiroaki Ueno; Akira Maruyama; Motoyoshi Miyake; Etsuko Nakao; Kenichiro Nakao; Kohei Umezu; Issei Nitta
Archive | 1993
Akira Maruyama; Shigeru Ogawa; Satoshi Yamazaki; Akihiro Tobe
Archive | 1984
Issei Nitta; Kenichiro Nakao; Motoyoshi Miyake; Akira Maruyama; Junko Takashima; Hiroaki Ueno
Archive | 1987
Ryoji Kikumoto; Yoshikuni Tamao; Shinji Tonomura; Akira Maruyama; Shosuke Okamoto; Akiko Okunomiya
Archive | 1985
Ryoji Kikumoto; Akira Maruyama; Shosuke Okamoto; Akiko Okunomiya; Yoshikuni Tamao; Shinji Tonomura
Archive | 1999
Takayuki Oe; Hiroaki Ueno; Akira Maruyama; Katsuhiko Masuda
Archive | 1999
Takayuki Oe; Hiroaki Ueno; Akira Maruyama; Katsuhiko Masuda
Archive | 1993
Akira Maruyama; Shigeru Ogawa; Satoshi Yamazaki; Akihiro Tobe
Archive | 1993
Akira Maruyama; Shigeru Ogawa; Satoshi Yamazaki; Akihiro Tobe
