Alair Pedro Ribeiro

Serum levels of nitric oxide and protein oxidation in goats seropositive for Toxoplasma gondii and Neospora caninum

The aim of this study was to assess and analyze the levels of nitric oxide (NO) and advanced oxidation protein products (AOPP) in serum of goats naturally infected by Toxoplasma gondii, Neospora caninum, or concomitantly infected by these two parasites. Thus, it was measured NOx and AOPP levels in twenty (n=20) sera samples of goats seronegative for T. gondii and N. caninum [negative control group (A)]; while the positive groups were composed by sera of infected animals, twelve (n=12) seropositive for N. caninum [group B]; eighteen (n=18) positive for T. gondii [group C]; and thirteen (n=13) seropositive for N. caninum and T. gondii [group D]. As results, it was observed that animals seropositive for N. caninum and T. gondii (Groups B to D) showed higher serum levels of NOx (P<0.001; F=9.5), when compared with seronegative animals. Additionally, it was observed a positive correlation between NOx levels and antibodies titrations for N. caninum (P<0.01; r=0.68) and T. gondii (P<0.05; r=0.56). AOPP levels were increase in groups C and D (P>0.05). Interestingly, group B did not show increase in AOPP, what led us to hypothesize that the major protein damage is linked to T. gondii infection. Therefore, our results showed an increased in NOx levels, which was probably related to the immune response, since it is an important inflammatory mediator; and AOPP were increased in groups where there was seropositivity for T. gondii, but not for the group composed only by animals seropositive for N. caninum, allowing us to suggest higher protein damage in toxoplasmosis.

Stimulation by Light and Sound: Therapeutics Effects in Humans. Systematic Review.

Introduction : The objective of the study was to make a systematic review of published studies that used the brain stimulation by light and sound as means to optimize brain function and increase the different treatments. Methods : The methods followed the Prisma model for eligibility of studies. Results : Four studies on the systematic review were included 3 experimental studies and 1 case report. Two of these studies were focused in learning and sportive performance, and 2 focused on increasing physical and mental health. Conclusion : It was concluded that the investigation of brain stimulation technique can be applied to induce favorable mental states to enlarge treatments of several disorders that affect humans in a safe and noninvasive way. It is suggested that positive results can also be found through the association of brain stimulation by light and sound with therapies that combat depression and anxiety states.