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Dive into the research topics where Alan David Borthwick is active.

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Featured researches published by Alan David Borthwick.


Bioorganic & Medicinal Chemistry | 2017

Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

Earl Clarke; Christopher I. Jarvis; Maria B. Goncalves; S. Barret Kalindjian; David Reginald Adams; Jane Theresa Brown; Jason J. Shiers; David Michel Adrien Taddei; Elodie Ravier; Stephanie Barlow; Iain Miller; Vanessa Smith; Alan David Borthwick; Jonathan Corcoran

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Journal of Medicinal Chemistry | 2006

Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency

Alan David Borthwick; John Liddle; Dave E. Davies; Anne M. Exall; Christopher Hamlett; Deirdre Mary Bernadette Hickey; Andrew Mcmurtrie Mason; Ian Edward David Smith; Fabrizio Nerozzi; Simon Peace; Derek Pollard; Steve L. Sollis; Michael J. Allen; Patrick M. Woollard; Mark Pullen; Timothy D. Westfall; Dinesh J. Stanislaus


Journal of Medicinal Chemistry | 2007

Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-Morpholin-4-Yl-2-Oxoethyl]-2-Oxopyrrolidin-3-Yl}Sulfonamides.

Chuen Chan; Alan David Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Laiq Chaudry; Chun-wa Chung; J. Nicole Hamblin; Lisa Johnstone; Henry A. Kelly; Savvas Kleanthous; Angela Patikis; Champa Patel; Anthony J. Pateman; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston; Caroline Whitworth; and Robert J. Young; Ping Zhou


American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2007

Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat

Gerald P. McCafferty; Mark Pullen; Charlene Wu; Richard M. Edwards; Michael J. Allen; Patrick M. Woollard; Alan David Borthwick; John Liddle; Deirdre Mary Bernadette Hickey; David P. Brooks; Timothy D. Westfall


Archive | 2004

Pyrrolidine -2-ones as factor xa inhibitors

Alan David Borthwick; Henry A. Kelly; Nigel S. Watson; Robert J. Young


Journal of Medicinal Chemistry | 2010

Oral Oxytocin Antagonists

Alan David Borthwick


Archive | 2002

Substituted diketopiperazines as oxytocin antagonists

Alan David Borthwick; Richard Jonathan Hatley; Deirdre Mary Bernadette Hickey; John Liddle; David G. Livermore; Andrew Mcmurtrie Mason; Neil Derek Miller; Fabrizio Nerozzi; Steven Leslie Sollis; Anna Katrin Szardenings; Paul G. Wyatt


Archive | 2002

2-(3-Sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors

Alan David Borthwick; Matthew GlaxoSmithKline Campbell; Chuen Glaxosmithkline Chan; Henry A. Kelly; Nigel Paul King; Savvas Kleanthous; Andrew McMurtrie GlaxoSmithKline Mason; Stefan Senger; Paul W. Smith; Nigel S. Watson; Robert J. Young


Archive | 1999

Pyrrolopyrrolone derivatives as antiviral agents

Alan David Borthwick; David E. Davies; Anne M. Exall; John Henry Leahy; George Saad Rahim; Pritom Shah; Stephen Sollis; Gordon G. Weingarten


Archive | 2005

Piperazinediones as oxytocin receptor antagonists

Alan David Borthwick; Deirdre Mary B. GlaxoSmithKline Hickey; John Liddle; Andrew McMurtrie GlaxoSmithKline Mason

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Nigel S. Watson

University of Hertfordshire

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