Henry A. Kelly

A practical drug discovery project at the undergraduate level.

In this article, we describe a practical drug discovery project for third-year undergraduates. No previous knowledge of medicinal chemistry is assumed. Initial lecture workshops cover the basic principles; then students, in teams, seek to improve the profile of a weakly potent, insoluble phosphatidylinositide 3-kinase delta (PI3Kδ) inhibitor (1) through compound array design, molecular modelling, screening data analysis and the synthesis of target compounds in the laboratory. The project benefits from significant industrial support, including lectures, student mentoring and consumables. The aim is to make the learning experience as close as possible to real-life industrial situations. In total, 48 target compounds were prepared, the best of which (5b, 5j, 6b and 6ap) improved the potency and aqueous solubility of the lead compound (1) by 100-1000 fold and ≥tenfold, respectively.

Reflection in a Workplace Qualification: Challenges and Benefits.

Purpose – The purpose of this paper is to discuss the challenges and benefits that arose from the implementation of an innovative example of employer responsive provision, i.e. of a postgraduate programme that is work‐based and designed specifically to meet the needs of the organisation.Design/methodology/approach – The approach is to outline the principles and challenges involved in designing a postgraduate programme that combines both scientific and personal/professional development in a way that is extremely unusual. In order to achieve this, in addition to assessment of technical scientific skills, it was necessary to integrate pedagogy that would support critical reflection on wider professional practice into the programme. The use of reflection on practice adopted an approach which is not familiar to the scientific community.Findings – Adoption of reflection on practice introduced particular challenges for programme design and delivery that required those involved to review their own practice critic...