Albert Kreutner

Intravascular papillary endothelial hyperplasia. Light and electron microscopic observations of a case

The ultrastructure of a case of intravascular papillary endothelial hyperplasia is presented. The papillae and septa within the lesion showed a similar organization. The surface was lined by a nonstratified layer of plump endothelial cells. Immediately beneath lay cells and processes of pericytes rich in thin filaments with fusiform densities, resembling smooth muscle cells. Primitive mesenchymal cells were observed to lie among the pericytes. The stroma beyond the subendothelial layer was collagenous and contained fibroblasts. The ultrastructure of the cells and their organization closely resembles human granulation tissue. Cancer 42:2304–2310, 1978.

Radical hysterectomy: A critical review of twenty-two years' experience

One hundred seventy-eight patients who had radical hysterectomy performed for management of invasive carcinoma of the cervix over 22 year period at the Medical University of South Carolina were critically analyzed. The degree of differentiation of the malignancy appeared to be of more significance than tumor size in Stage 1 lesions. With proper patient selection and excellent operative technique, survival rates well over 90% with minimal complications can be obtained. The radical hysterectomy should never be used in association with irradiation.

Carcinoma of the endometrium: Radiation followed immediately by operation☆

A prospective study was established in August, 1967, to treat all adenocarcinomas of the endometrium by protocols of preoperative radiation followed immediately by operation. Two hundred and ninety-five women have been treated, 220 of whom had Stage I disease. In these cases, factors known to be associated with survival were studied, and their influence upon survival was noted. Preoperative radium followed immediately by operation was the primary method of therapy. Life tables demonstrated a five-year survival rate of 91 per cent with a low complication rate in patients with Stage I disease. Cell type, degree of differentiation, and depth of myomentrial invasion were the primary factors influencing survival.

Malignant inflammatory histiocytoma (inflammatory fibrous histiocytoma) report of a patient with four lesions

A patient with four subcutaneous inflammatory fibrous histiocytomas is presented. Three of these tumors developed synchronously. The neoplasms were examined by light and electron microscopy and were composed of well differentiated histiocytes, multinucleated histiocytes, and less differentiated cells. The ultrastructural findings support the histiocytic nature of this particular tumor.

Metastatic placental tumors: Report of three cases

THE SPREAD OF CANCER in man to distant sites is nothing new to the medical community; however, metastasis to the placenta of a gravid woman stirs the interest of most physicians. A review of the medical literature reveals only 36 such case reports which are dominated by metastatic melanoma, breast cancer, and the leukemic-Iymphoma groups. The purpose of this paper is to cite three case histories with placental metastasis encountered since 1968 in the Department of Obstetrics and Gynecology at the Medical University of South Carolina.

Endometrial carcinoma: A new method of classification of therapeutic and prognostic significance

Abstract A retrospective study has been performed on 120 patients with Stage I carcinoma of the endometrium searching for a prognostic index based on histological evaluation of cell type, grade of differentiation, and depth of myometrial invasion measured from the serosal surface in millimeters. A program of therapy is outlined as well as a method of treating the pathological specimen so that this prognostic index can be systematically applied to all patients with this disease. From this study, patients who have disease with 5 mm of the serosal surface of the uterus are believed to be candidates for more extensive methods of treatment than generally applied to Stage I disease of the uterus.

Hemorrhagic Cystitis and Ureteritis, and Interstitial Nephritis Associated with Administration of Penicilling

Hemorrhagic cystitis and ureteritis, and interstitial nephritis developed in a patient receiving penicillin G and streptomycin as therapy for bacterial endocarditis. After therapy was changed to vancomycin there was prompt resolution of these abnormalities.

Histology of the Endometrium in Long Term Use of A Sequential Oral Contraceptive

Non-atypical adenomatous hyperplasia was found in 13.5% of 111 biopsies obtained from long-term, predominantly black, users of Oracon. An association between length of time of use (95 cycles for those with adenomatous hyperplasia versus 73 for those without) and the development of adenomatous hyperplasia was noted, but there was no association with hypertension or obesity. Cystic glandular dilatation was seen in 63% but was not thought to represent hyperplasia. No more advanced lesions were seen.

Gonadoblastoma: Clinicopathologic correlation in six patients

Six patients with a total of nine gonadoblastomas are presented; three--and possibly a fourth--had dysgerminomatous overgrowth which was massive in two patients. Calcification detected by abdominal films was present in three sufficient for preoperative diagnosis. All patients were found to have a Y stem line on peripheral leukocyte chromosome cultures except one patient, who had a 46 XX/45 XO karyotype. She was found to have Y chromatin bodies in the germ cells of her tumor which was in a normal ovary found at exploration for an ectopic pregnancy. Three were found in virilized phenotypic females investigated for amenorrhea, and two for therapy of pelvic masses due to dysgerminomatous overgrowth. Y chromatin studies are reported on gonadal tissue.

Retrograde lymphatic spread and ischemia of the forearm and hand—rare complications of carcinoma of the breast

A case of ischemia of the forearm and hand with resulting necrosis three years following simple mastectomy and radiation therapy for breast carcinoma is reported. Histologic sections of the mid‐forearm amputation specimen showed extensive lymphatic involvement by tumor. The latter process is judged to have been one of retrograde lymphatic extension. Cancer 40:371–375, 1977.