Álefe Brito Monteiro
Federal University of Paraíba
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Publication
Featured researches published by Álefe Brito Monteiro.
Evidence-based Complementary and Alternative Medicine | 2013
Francisco Elizaudo de Brito Júnior; Dayanne Rakelly de Oliveira; Elizângela B. Bento; Laura Hi Leite; Daniele Oliveira Souza; Ana Luiza de Albuquerque Siebra; Renata de S Sampaio; Anita Oliveira Brito Pereira Bezerra Martins; Andreza Guedes Barbosa Ramos; Saulo R. Tintino; Luiz J. Lacerda-Neto; Patrícia Rosane Leite de Figueiredo; Larissa Rolim de Oliveira; Cristina Kelly de Sousa Rodrigues; Valterlúcio dos Santos Sales; Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Emmily Petícia do Nascimento; Álefe Brito Monteiro; Érika N. Amaro; José Galberto Martins da Costa; Henrique Douglas Melo Coutinho; Irwin Rose Alencar de Menezes; Marta Regina Kerntopf
Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.
Saudi Journal of Biological Sciences | 2016
Elizângela B. Bento; Francisco Elizaudo de Brito Júnior; Dayanne Rakelly de Oliveira; Cícera Norma Fernandes; Gyllyandeson de Araújo Delmondes; Francisco Rafael Alves Santana Cesário; Cristina Kelly de Sousa Rodrigues; Valterlúcio dos Santos Sales; Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Izabel Cristina Santiago Lemos; Álefe Brito Monteiro; Irwin Rose Alencar de Menezes; José Galberto Martins da Costa; Marta Regina Kerntopf
Annona muricata Linnaeus, popularly known as “graviola” and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent. The aim of the present study was to validate the gastroprotective activity of the hydroalcoholic extract of the leaves of A. muricata (HEAM) and to investigate the underlying mechanisms of action for this effect. Gastric lesions were induced in mice by absolute ethanol, acidified ethanol or indomethacin. Before, the animals were pretreated with saline, omeprazole or HEAM orally at doses of 50–400 mg/kg. To determine the mechanism of action of the extract, we investigated, using specific inhibitors, the involvement of nitric oxide (NO), prostaglandins (PGEs), ATP-dependent K+ channels and α2-noradrenergic receptors. HEAM showed significant antiulcer activity against lesions induced by absolute ethanol, acidified ethanol or indomethacin, which was mediated by endogenous gastric prostaglandins.
Fundamental & Clinical Pharmacology | 2018
Cícero Francisco Bezerra Felipe; Aline Mirely Sousa Albuquerque; João Luis Xavier de Pontes; José Ítalo Vieira de Melo; Teresa Carolliny Moreira Lustoza Rodrigues; Ada Mirtes Pereira de Sousa; Álefe Brito Monteiro; Ana Elisa da Silva Ribeiro; Janice Pereira Lopes; Irwin Rose Alencar de Menezes; Reinaldo Nóbrega de Almeida
Convulsions occur in response to a loss of balance between excitatory and inhibitory neurotransmitters, and the treatment for this condition consists in restore such lost balance. Many anticonvulsant drugs present side effects which may limit their use. This fact has stimulated the search for new sources of treatment from aromatic plants. Many monoterpenes commonly present in essential oils are known because of their anticonvulsant properties. The anticonvulsant effect of α‐ and β‐pinene, two structural isomers, is still little studied. Thus, the present work evaluated the anticonvulsant effect of α‐ and β‐pinene in pentylenetetrazole‐induced convulsions model. Initially, the oral LD50 for α‐ and β‐pinene was estimated. Following the oral administration, a mild sedation was observed and no deaths were recorded; the LD50 estimated for both monoterpenes was greater than 2 000 mg/kg, p.o. Further, animals were orally treated with α‐pinene (100, 200 and 400 mg/kg), β‐pinene (100, 200 and 400 mg/kg) and the equimolar mixture of α‐ and β‐pinene (400 mg/kg) and subjected to the pentylenetetrazole‐induced convulsions model. In this model, only the dose of 400 mg/kg of the compounds was able to significantly decrease the seizure intensity. The latency of first convulsion was significantly increased by the mixture of α‐ and β‐pinene (400 mg/kg). In addition, β‐pinene and the mixture of the two monoterpenes, both at a dose of 400 mg/kg, significantly increased the time of death of animals. The treatment with β‐pinene and the equimolar mixture of the two monoterpenes significantly reduced hippocampal nitrite level and striatal content of dopamine (DA) and norepinephrine (NE). Taken together, the results suggest that α‐pinene appears to be devoid of anticonvulsant action. This fact, however, seems to be dependent on the chemical structure of the compound, since pretreatment with the β‐pinene increased the time of death pf PTZ‐treated mice, which seems to depend on the ability of the compound to reduce nitrite concentration and NE and DA content, during the pentylenetetrazole‐induced seizure.
Revista Cubana de Plantas Medicinales | 2015
Camila Esmeraldo Paz; Izabel Cristina Santiago Lemos; Álefe Brito Monteiro; Gyllyandeson de Araújo Delmondes; George Pimentel Fernandes; Henrique Douglas Melo Coutinho; Cícero Francisco Bezerra Felipe; Irwin Rose Alencar de Menezes; Marta Regina Kerntopf
Journal of Food and Nutrition Research | 2015
Patrícia Rosane Leite de Figueiredo; Ana Luiza de Albuquerque Siebra; Luiz Jardelino de Lacerda Neto; Larissa Rolim de Oliveira; Andreza Guedes Barbosa Ramos; Gyllyandeson de Araújo Delmondes; Izabel Cristina Santiago Lemos; Cícera Norma Fernandes; Saulo R. Tintino; Álefe Brito Monteiro; Dayanne Rakelly de Oliveira; Francisco Elizaudo de Brito Júnior; Francisca Valéria Soares de Araújo Pinho; Valter Menezes Barbosa Filho; Francisco Assis Bezerra da Cunha; Alexandre Magno Rodrigues Texeira; Roseli Barbosa; Diniz Maciel de Sena Junior; Cícero Francisco Bezerra Felipe; José Galberto Martins da Costa; Henrique Douglas Melo Coutinho; Irwin de Menezes; Marta Regina Kerntopf
Cadernos de Cultura e Ciência | 2014
Marta Regina Kerntopf; Gyllyandeson de Araújo Delmondes; Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Larissa Rolim de Oliveira; Álefe Brito Monteiro; Valterlúcio dos Santos Sales; Cristina Kelly de Sousa Rodrigues; Emmily Petícia do Nascimento; Maria Celeste Vega Gomez; Cathia Coronel; José Galberto Martins da Costa; Henrique Douglas Melo Coutinho; Cícero Francisco Bezerra Felipe; Irwin Rose Alencar de Menezes
Revista Ciencias de la Salud | 2018
Francisco Rodolpho Sobreira Dantas Nóbrega de Figueirêdo; Ana Jaqueline Bitu Primo; Álefe Brito Monteiro; Saulo R. Tintino; Gyllyandeson de Araújo Delmondes; Valterlúcio dos Santos Sales; Cristina Kelly de Souza Rodrigues; Cícero Francisco Bezerra Felipe; Henrique Douglas Melo Coutinho; Marta Regina Kerntopf
Journal of Biology & Pharmacy and Agricultural Management | 2018
Maiara Monike de Sousa Leite; Álefe Brito Monteiro
Iranian Journal of Pharmaceutical Research | 2018
Daniele Oliveira Souza; Valterlúcio dos Santos Sales; Cristina Kelly de Sousa Rodrigues; Larissa de Oliveira; Izabel Cristina Santiago Lemos; Gyllyandeson de Araújo Delmondes; Álefe Brito Monteiro; Emmily do Nascimento; Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; José Galberto da Costa; Giovany Michely Pinto da Cruz; Glauce Socorro de Barros Viana; Roseli Barbosa; Irwin de Menezes; Cícero Francisco Bezerra Felipe; Marta Regina Kerntopf
Iranian Journal of Pharmaceutical Research | 2018
Valterlúcio dos Santos Sales; Álefe Brito Monteiro; Gyllyandeson de Araújo Delmondes; Emmily Petícia do Nascimento; Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Cristina Kelly de Souza Rodrigues; Josefa Fernanda Evangelista de Lacerda; Cicera Norma Fernandes Lima; Maysa de Oliveira Barbosa; Adamo Xenofonte Brasil; Saulo R. Tintino; Maria Celeste Vega Gomez; Cathia Coronel; Henrique Douglas Melo Coutinho; José Galberto Martins da Costa; Cícero Francisco Bezerra Felipe; Irwin Rose Alencar de Menezes; Marta Regina Kerntopf
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Izabel Cristina Santiago Lemos
Universidade Federal Rural de Pernambuco
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