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Featured researches published by Alex Kou.


Journal of Ultrasound in Medicine | 2013

An In Vitro Study to Evaluate the Utility of the “Air Test” to Infer Perineural Catheter Tip Location

Kan J; T. Kyle Harrison; T. Edward Kim; Steven K. Howard; Alex Kou; Edward R. Mariano

Injection of air under ultrasound guidance via a perineural catheter after insertion (“air test”) has been described as a means to infer placement accuracy, yet this test has never been rigorously evaluated. We tested the hypothesis that the air test predicts accurate catheter location greater than chance and determined the tests sensitivity, specificity, and positive and negative predictive values using a porcine‐bovine model and blinded expert in ultrasound‐guided regional anesthesia. The air test improved the expert clinicians assessment of catheter tip position compared to chance, but there was no difference when compared to direct visualization of the catheter without air injection.


Seminars in Cardiothoracic and Vascular Anesthesia | 2016

Design and Implementation of a Perioperative Surgical Home at a Veterans Affairs Hospital

Tessa L. Walters; Steven K. Howard; Alex Kou; Edward J. Bertaccini; T. Kyle Harrison; T. Edward Kim; Audrey Shafer; Carlos Brun; Natasha Funck; Lawrence C. Siegel; Erica Stary; Edward R. Mariano

The innovative Perioperative Surgical Home model aims to optimize the outcomes of surgical patients by leveraging the expertise and leadership of physician anesthesiologists, but there is a paucity of practical examples to follow. Veterans Affairs health care, the largest integrated system in the United States, may be the ideal environment in which to explore this model. We present our experience implementing Perioperative Surgical Home at one tertiary care university-affiliated Veterans Affairs hospital. This process involved initiating consistent postoperative patient follow-up beyond the postanesthesia care unit, a focus on improving in-hospital acute pain management, creation of an accessible database to track outcomes, developing new clinical pathways, and recruiting additional staff. Today, our Perioperative Surgical Home facilitates communication between various services involved in the care of surgical patients, monitoring of patient outcomes, and continuous process improvement.


Regional Anesthesia and Pain Medicine | 2016

Comparative-Effectiveness of Simulation-Based Deliberate Practice Versus Self-Guided Practice on Resident Anesthesiologists' Acquisition of Ultrasound-Guided Regional Anesthesia Skills.

Ankeet D. Udani; Harrison Tk; Edward R. Mariano; Derby R; Kan J; Toni Ganaway; Cynthia Shum; David M. Gaba; Pedro Paulo Tanaka; Alex Kou; Steven K. Howard

Background and Objectives Simulation-based education strategies to teach regional anesthesia have been described, but their efficacy largely has been assumed. We designed this study to determine whether residents trained using the simulation-based strategy of deliberate practice show greater improvement of ultrasound-guided regional anesthesia (UGRA) skills than residents trained using self-guided practice in simulation. Methods Anesthesiology residents new to UGRA were randomized to participate in either simulation-based deliberate practice (intervention) or self-guided practice (control). Participants were recorded and assessed while performing simulated peripheral nerve blocks at baseline, immediately after the experimental condition, and 3 months after enrollment. Subject performance was scored from video by 2 blinded reviewers using a composite tool. The amount of time each participant spent in deliberate or self-guided practice was recorded. Results Twenty-eight participants completed the study. Both groups showed within-group improvement from baseline scores immediately after the curriculum and 3 months following study enrollment. There was no difference between groups in changed composite scores immediately after the curriculum (P = 0.461) and 3 months following study enrollment (P = 0.927) from baseline. The average time in minutes that subjects spent in simulation practice was 6.8 minutes for the control group compared with 48.5 minutes for the intervention group (P < 0.001). Conclusions In this comparative effectiveness study, there was no difference in acquisition and retention of skills in UGRA for novice residents taught by either simulation-based deliberate practice or self-guided practice. Both methods increased skill from baseline; however, self-guided practice required less time and faculty resources.


Healthcare | 2016

The Perioperative Surgical Home model facilitates change implementation in anesthetic technique within a clinical pathway for total knee arthroplasty.

Seshadri C. Mudumbai; Tessa L. Walters; Steven K. Howard; T. Edward Kim; Gregory Milo Lochbaum; Stavros G. Memtsoudis; Zeev N. Kain; Alex Kou; Robert King; Edward R. Mariano

BACKGROUND The challenge of knowledge translation in medical settings is well known, and implementing change in clinical practice can take years. For the increasing number total knee arthroplasty (TKA) patients annually, there is ample evidence to endorse neuraxial anesthesia over general anesthesia. The rate of adoption of this practice, however, is slow at the current time. We hypothesized that a Perioperative Surgical Home (PSH) model facilitates rapid change implementation in anesthesia. METHODS The PSH clinical pathways workgroup at a tertiary care Veterans Affairs hospital embarked on a 5-month process of changing the preferred anesthetic technique for patients undergoing TKA. This process involved multiple sequential steps: literature review; development of a work document; training of staff; and prospective collection of data. To assess the impact of this change, we examined data 6 months before (PRE, n=90) and after (POST) change implementation (n=128), and our primary outcome was the overall proportion of spinal anesthesia usage for each 6 month period. Secondary outcomes included minor and major complications associated with anesthetic technique. RESULTS Over a period of one year, there was an increase in the proportion of patients who received spinal anesthesia (13% vs. 63%, p<0.001). For the following year, 53-92% of TKA patients per month received spinal anesthesia. There were no differences in major complications. CONCLUSION Rapid and sustained change implementation in clinical anesthesia practice based on emerging evidence is feasible. IMPLICATIONS Perioperative Surgical Home model may facilitate rapid change implementation in surgical care. LEVEL OF EVIDENCE Cohort study, Level 2.


Pain Medicine | 2016

Availability and Readability of Online Patient Education Materials Regarding Regional Anesthesia Techniques for Perioperative Pain Management.

Gunjan Kumar; Steven K. Howard; Alex Kou; T. Edward Kim; Alexander J. Butwick; Edward R. Mariano

Objective Patient education materials (PEM) should be written at a sixth-grade reading level or lower. We evaluated the availability and readability of online PEM related to regional anesthesia and compared the readability and content of online PEM produced by fellowship and nonfellowship institutions. Methods With IRB exemption, we constructed a cohort of online regional anesthesia PEM by searching Websites from North American academic medical centers supporting a regional anesthesiology and acute pain medicine fellowships and used a standardized Internet search engine protocol to identify additional nonfellowship Websites with regional anesthesia PEM based on relevant keywords. Readability metrics were calculated from PEM using the TextStat 0.1.4 textual analysis package for Python 2.7 and compared between institutions with and without a fellowship program. The presence of specific descriptive PEM elements related to regional anesthesia was also compared between groups. Results PEM from 17 fellowship and 15 nonfellowship institutions were included in analyses. The mean (SD) Flesch-Kincaid Grade Level for PEM from the fellowship group was 13.8 (2.9) vs 10.8 (2.0) for the nonfellowship group (p = 0.002). We observed no other differences in readability metrics between fellowship and nonfellowship institutions. Fellowship-based PEM less commonly included descriptions of the following risks: local anesthetic systemic toxicity (p = 0.033) and injury due to an insensate extremity (p = 0.003). Conclusions Available online PEM related to regional anesthesia are well above the recommended reading level. Further, fellowship-based PEM posted are at a higher reading level than PEM posted by nonfellowship institutions and are more likely to omit certain risk descriptions.


Journal of Anesthesia | 2016

Feasibility of eye-tracking technology to quantify expertise in ultrasound-guided regional anesthesia

T. Kyle Harrison; T. Edward Kim; Alex Kou; Cynthia Shum; Edward R. Mariano; Steven K. Howard

Ultrasound-guided regional anesthesia (UGRA) requires an advanced procedural skill set that incorporates both sonographic knowledge of relevant anatomy as well as technical proficiency in needle manipulation in order to achieve a successful outcome. Understanding how to differentiate a novice from an expert in UGRA using a quantifiable tool may be useful for comparing educational interventions that could improve the rate at which one develops expertise. Exploring the gaze pattern of individuals performing a task has been used to evaluate expertise in many different disciplines, including medicine. However, the use of eye-tracking technology has not been previously applied to UGRA. The purpose of this preliminary study is to establish the feasibility of applying such technology as a measurement tool for comparing procedural expertise in UGRA. eye-tracking data were collected from one expert and one novice utilizing Tobii Glasses 2 while performing a simulated ultrasound-guided thoracic paravertebral block in a gel phantom model. Area of interest fixations were recorded and heat maps of gaze fixations were created. Results suggest a potential application of eye-tracking technology in the assessment of UGRA learning and performance.


Journal of Ultrasound in Medicine | 2015

Evaluation of a Standardized Program for Training Practicing Anesthesiologists in Ultrasound-Guided Regional Anesthesia Skills

Edward R. Mariano; T. Kyle Harrison; T. Edward Kim; Kan J; Cynthia Shum; David M. Gaba; Toni Ganaway; Alex Kou; Ankeet D. Udani; Steven K. Howard

Practicing anesthesiologists have generally not received formal training in ultrasound‐guided perineural catheter insertion. We designed this study to determine the efficacy of a standardized teaching program in this population.


Journal of Ultrasound in Medicine | 2014

A pilot in vitro evaluation of the "air test" for perineural catheter tip localization by a novice regional anesthesiologist.

Jason Johns; T. Kyle Harrison; Lauren Steffel; Steven K. Howard; T. Edward Kim; Alex Kou; Edward R. Mariano

The “air test” is used clinically to infer perineural catheter location and has been recently evaluated for use by experts. However, its utility for practitioners with less experience is unknown. We tested the hypothesis that the air test, when performed by a novice regional anesthesiologist, will improve assessment of perineural catheter tip position in a validated porcine‐bovine model and determined the tests positive and negative predictive values, sensitivity, and specificity for a novice. In contrast to the results of the expert study, the air test did not improve the novices assessment of perineural catheter tip location over chance.


Journal of Ultrasound in Medicine | 2016

Comparative Effectiveness of Two Ultrasound-Guided Regional Block Techniques for Surgical Anesthesia in Open Unilateral Inguinal Hernia Repair

Lauren Steffel; T. Edward Kim; Steven K. Howard; Daphne P. Ly; Alex Kou; Robert King; Edward R. Mariano

Transversus abdominis plane (TAP) and ilioinguinal/iliohypogastric (II/IH) nerve blocks have been described as analgesic adjuncts for inguinal hernia repair, but the efficacy of these techniques in providing intraoperative anesthesia, either individually or together, is not known. We designed this retrospective cohort study to test the hypothesis that combining TAP and II/IH nerve blocks (“double TAP” technique) results in greater accordance between the preoperative anesthetic plan and actual anesthetic technique provided when compared to TAP alone. Based on this study, double TAP may be preferred for patients undergoing open inguinal hernia repair who wish to avoid general anesthesia.


Korean Journal of Anesthesiology | 2016

An ultrasound-guided fascia iliaca catheter technique does not impair ambulatory ability within a clinical pathway for total hip arthroplasty

Seshadri C. Mudumbai; T. Edward Kim; Steven K. Howard; Nicholas J. Giori; Steven T. Woolson; Toni Ganaway; Alex Kou; Robert King; Edward R. Mariano

Background Both neuraxial and peripheral regional analgesic techniques offer postoperative analgesia for total hip arthroplasty (THA) patients. While no single technique is preferred, quadriceps muscle weakness from peripheral nerve blocks may impede rehabilitation. We designed this study to compare postoperative ambulation outcome in THA patients who were treated with a new ultrasound-guided fascia iliaca catheter (FIC) technique or intrathecal morphine (ITM). Methods We reviewed the electronic health records of a sequential series of primary unilateral THA patients who were part of a standardized clinical pathway; apart from differences in regional analgesic technique, all other aspects of the pathway were the same. Our primary outcome was total ambulation distance (meters) combined for postoperative days 1 and 2. Secondary outcomes included daily opioid consumption (morphine milligram equivalents) and analgesic-related side effects. We examined the association between the primary outcome and analgesic technique by performing crude and adjusted ordinary least-squares linear regression. A P value < 0.05 was considered statistically-significant. Results The study analyzed the records of 179 patients (fascia iliaca, n = 106; intrathecal, n = 73). The primary outcome (total ambulation distance) did not differ between the groups (P = 0.08). Body mass index (BMI) was the only factor (β = -1.7 [95% CI -0.5 to -2.9], P < 0.01) associated with ambulation distance. Opioid consumption did not differ, while increased pruritus was seen in the intrathecal group (P < 0.01). Conclusions BMI affects postoperative ambulation outcome after hip arthroplasty, whereas the type of regional analgesic technique used does not. An ultrasound-guided FIC technique offers similar analgesia with fewer side effects when compared with ITM.

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Cynthia Shum

VA Palo Alto Healthcare System

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Robert King

VA Palo Alto Healthcare System

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Kan J

Stanford University

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