Is this you? Create Your Porfile
Avatar

Alexander Fassler

Novartis

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Alexander Fassler is active.

Explore More

Publication

Featured researches published by Alexander Fassler.

Tetrahedron Letters | 2000

A convergent synthesis of the renin inhibitor CGP60536B

David Andrew Sandham; Roger John Taylor; John S Carey; Alexander Fassler

Abstract Pseudoephedrine serves as a dual purpose chiral auxiliary and protecting group in the synthesis of the novel orally active renin inhibitor CGP60536B.

Bioorganic & Medicinal Chemistry Letters | 1993

Novel pseudosymmetric inhibitors of HIV-1 protease

Alexander Fassler; Johannes Dr. Rösel; M. Grüther; Marina Tintelnot-Blomley; E. Atteri; Guido Bold; Marc Lang

Abstract Compounds containing the easily accessible Phe[CH(OH)CH2N(NH)Phe dipeptide isostere as a non-hydrolyzable replacement of the scissile amide bond in the natural substrate are potent inhibitors of HIV-1 protease. The expected symmetric binding pattern of the most potent inhibitor in this series (CGP 53280, IC50 = 9 nM) is illustrated by the X-ray analysis performed with the corresponding enzyme-inhibitor complex.

Journal of Medicinal Chemistry | 1998

New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development

Guido Bold; Alexander Fassler; Hans-Georg Capraro; Robert Cozens; Thomas Klimkait; Janis Lazdins; Bernard Poncioni; Johannes Rösel; David Stover; Marina Tintelnot-Blomley; Figan Acemoglu; Werner Beck; Eugen Boss; Martin Eschbach; Thomas Hürlimann; Elvira Masso; Serge Roussel; Katharina Ucci-Stoll; Dominique Wyss; Marc Lang

Archive | 1997

Antivirally active heterocyclic azahexane derivatives

Alexander Fassler; Guido Bold; Hans-Georg Capraro; Marc Lang; Satish Chandra Khanna

Journal of Medicinal Chemistry | 1996

Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability

Alexander Fassler; Guido Bold; Hans-Georg Capraro; Robert Cozens; Bernard Poncioni; Johannes Rösel; Marina Tintelnot-Blomley; Marc Lang

Archive | 1995

Antiviral ethers of aspartate protease substrate isosteres

Guido Bold; Hans-Georg Capraro; Alexander Fassler; Marc Lang; Shripad S. Bhagwat; Satish Chandra Khanna; Janis Lazdins

Archive | 1994

Cyclic hydrazine compounds

Guido Bold; Shripad S. Bhagwat; Alexander Fassler; Marc Lang

Archive | 1992

Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use

Marc Lang; Guido Bold; Alexander Fassler; Peter Schneider; Hoogevest Peter Van

Archive | 1989

Use of peptide isosteres as retroviral protease inhibitors

Alexander Fassler; Ernst Hungerbühler; Johannes Dr. Rösel; Heinrich Rüeger; Peter Schneider; Jeanette Dr. Wood

Archive | 1995

Antiretroviral hydrazine derivatives

Alexander Fassler; Guido Bold; Marc Lang; Shripad S. Bhagwat; Peter Schneider

Explore More

Collaboration

Dive into the Alexander Fassler's collaboration.

Top Co-Authors
Avatar

Guido Bold

Novartis

View shared research outputs
Top Co-Authors
Avatar

Marc Lang

Novartis

View shared research outputs
Top Co-Authors
Avatar

Peter Schneider

Novartis

View shared research outputs
Top Co-Authors
Avatar

Hans-Georg Capraro

Novartis

View shared research outputs
Top Co-Authors
Avatar

Johannes Rösel

Novartis

View shared research outputs
Top Co-Authors
Avatar

Shripad S. Bhagwat

Novartis

View shared research outputs
Top Co-Authors
Avatar

Bernard Poncioni

Novartis

View shared research outputs
Top Co-Authors
Avatar

Ernst Hungerbühler

Novartis

View shared research outputs
Top Co-Authors
Avatar

Heinrich Rüeger

Novartis

View shared research outputs
Top Co-Authors
Avatar

Janis Lazdins

Novartis

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge