Ernst Hungerbühler

Fluoroolefin dipeptide isosteres — I.: The synthesis of Glyψ(CFCH)Gly and racemic Pheψy(CFCH)Gly

Abstract The syntheses of Gly-Gly and racemic Phe-Gly fiuoroolefin dipeptide isosteres are described, the first examples of a new class of peptide analogues.

(+)-Colletodiol synthesis from (S.S)-tartaric acid and (R)-3-hydroxy-butyric acid

Abstract E-(R)-5-Hydroxy-2-hexenoic acid (4) and the acetonide of E-(4R,5R,7R)-trihydroxy-2-octenoic acid (3) are joined to give, after deprotection, (+)-colletodiol (1). The syntheses of the two hydroxy-acids from poly-(R)-3-hydroxy-butanoate (PHB) and (−)-tartaric acid, respectively, are outlined.