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Dive into the research topics where Alexander Hillisch is active.

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Featured researches published by Alexander Hillisch.


Steroids | 1998

The remarkable influence of steroid A/B-ring junction on the Wittig olefination reaction of the 11-oxo group : Towards the synthesis of 5α- and 5β-oriented Δ3-isomers of desogestrel

Sven Ring; Gisela Weber; Alexander Hillisch; Sigfrid Schwarz

Abstract The 5α- and 5β-oriented Δ 3 -double bond isomers 8, 9 of the widely used progestin desogestrel (7) were synthesized. Wittig olefination reaction of the 5α-intermediate 12 showed a dramatically reduced reaction rate compared with the olefination of the 5β-intermediate 13 . Computational studies suggest that different energies of the intermediary 1,2-oxaphosphetanes may, at least partially, have been the reason for this phenomenon.


Archive | 2003

9-α-substituted estratrienes as selectively active estrogens

Dirk Kosemund; Gerd Mueller; Alexander Hillisch; Karl-Heinrich Fritzemeier; Peter Muhn


Archive | 2004

Antitumor wirksame 2-substituierte d-homoestra-1,3,5(10)-trien-3-yl sulfamate

Alexander Hillisch; Olaf Peters; Christian Gege; Gerhard Siemeister; Eberhard Unger; Bernd Menzenbach


Archive | 2000

Ent-steroids as selectively active estrogens

Siegfried Schwarz; Dirk Kosemund; Gerd Müller; Margit Richter; Olaf Peters; Peter Droescher; Walter Elger; Alexander Hillisch; Ulf Bömer; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung


Archive | 2005

2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Alexander Hillisch; Olaf Peters; Christian Gege; Wilko Regenhardt; Andrea Rosinus; Jerzy Adamski; Gabriele Moeller; Walter Elger; Birgitt Schneider; Ulrich Bothe


Archive | 2003

Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy

Alexander Hillisch; Walter Elger; Gerd Schubert; Birgitt Schneider; Gudrun Reddersen


Archive | 2004

11-Beta substituted 19-nor-17-alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring

Alexander Hillisch; Walter Elger; Rolf Bohlmann; Jens Hoffmann


Archive | 2003

Antitumor wirksame 2-alkoxyestradiolsulfamate

Ina Scherlitz-Hofmann; Jens Hoffmann; Alexander Hillisch; Eberhard Unger; Tobias Neumann; Sigfrid Schwarz; Olaf Peters; Thomas Michel


Archive | 2005

17alpha-fluorosteroids, pharmaceutical compositions containing 17alpha-fluorosteroids and a method of making them

Ulrich Bothe; Peter Droescher; Walter Elger; Gudrun Reddersen; Bernd Menzenbach; Hans-Udo Schweikert; Alexander Hillisch; Birgett Schneider


Archive | 2004

8

Nico Bräuer; Olaf Peters; Alexander Hillisch; Rolf Bohlmann; Margit Richter; Hans Peter Muhn

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