Alexander Karpeisky
Sirna Therapeutics
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Featured researches published by Alexander Karpeisky.
Journal of The Chemical Society-perkin Transactions 1 | 1994
Alexander Karpeisky; Sergey Zavgorodny; Matti Hotokka; Mikko Oivanen; Harri Lönnberg
Kinetics of the acid-catalysed hydrolysis of O5′,8-cycloadenosine, S5′, 8-cyclo-5′-thioadenosine and N5′, 8-cyclo-5′-amino-5′-deoxyadenosine have been studied. The S- and N-bridged cyclonucleosides are hydrolysed exclusively by the rupture of the N-glycosidic bond, while the O-bridged compound undergoes concurrent cleavage of the N-glycosidic and 5′,8-cyclo linkages, the proportion of the former reaction being markedly increased with increasing temperature. The conformations of the same cyclonucleosides have been elucidated by molecular modelling (SYBYL) and 1H NMR spectroscopy. The effect of the sugar ring puckering on the hydrolytic stability is discussed.
Bone reports | 2018
Kristen B. Farrell; Alexander Karpeisky; Douglas H. Thamm; Shawn Zinnen
Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bone remains an important goal for achieving effective treatments. Drug targeting strategies have improved drug localization to bone by taking advantage of the high mineral concentration unique to the bone hydroxyapatite matrix, as well as tissue-specific cell types. The bisphosphonate molecule class binds specifically to hydroxyapatite and inhibits osteoclast resorption of bone, providing direct treatment for degenerative bone disorders, and as emerging evidence suggests, cancer. These bone-binding molecules also provide the opportunity to deliver other drugs specifically to bone by bisphosphonate conjugation. Bisphosphonate bone-targeted therapies have been successful in treatment of osteoporosis, primary and metastatic neoplasms of the bone, and other bone disorders, as well as refining bone imaging. In this review, we focus upon the use of bisphosphonate conjugates with antineoplastic agents, and overview bisphosphonate based imaging agents, nanoparticles, and other drugs. We also discuss linker design potential and the current state of bisphosphonate conjugate research progress. Ongoing investigations continue to expand the possibilities for bone-targeted therapeutics and for extending their reach into clinical practice.
Archive | 1998
Leonid Beigelman; Jasenka Matulic-Adamic; Alexander Karpeisky; Peter Haeberli; David Sweedler; Mark Reynolds; Nilabh Chaudhary; John Min
Archive | 1999
Leonid Beigelman; Alex B. Burgin; Amber Beaudry; Alexander Karpeisky; Jasenka Matulic-Adamic; David Sweedler; Shawn Zinnen
Archive | 2003
James Thompson; Leonid Beigelman; James McSwiggen; Alexander Karpeisky; Laurent Bellon; Mark Reynolds; Michael Zwick; Thale Jarvis; Tod Woolf; Peter Haeberli; Jasenka Matulic-Adamic
Bone | 2010
Monica M. Reinholz; Shawn Zinnen; Amylou C. Dueck; David Dingli; Gregory G. Reinholz; Leslie A. Jonart; Kathleen Kitzmann; Amy K. Bruzek; Vivian Negron; Abdalla K. Abdalla; Bonnie K. Arendt; Anthony J. Croatt; Luis Sanchez-Perez; David P. Sebesta; Harri Lönnberg; Toshiyuki Yoneda; Karl A. Nath; Diane F. Jelinek; Stephen J. Russell; James N. Ingle; Thomas C. Spelsberg; Henry B.F. (Hal) Dixon; Alexander Karpeisky; Wilma L. Lingle
Journal of Organic Chemistry | 2008
Mikko Ora; Tuomas Lönnberg; Diana Florea-Wang; Shawn Zinnen; Alexander Karpeisky; Harri Lönnberg
Archive | 2003
Leonid Beigelman; Peter Haeberli; Alexander Karpeisky; David Sweedler
Journal of Clinical Oncology | 2017
Shawn Zinnen; Eric K. Rowinsky; Alexander Alexandrov; Larisa Plekhova; Marina Roudas; Alexander Karpeisky
Bone | 2011
Shawn Zinnen; Douglas H. Thamm; David M. Vail; Timothy M. Fan; Alexander Karpeisky