Alexandra Bulgarelli do Nascimento

A relação entre polifarmácia, complicações crônicas e depressão em portadores de Diabetes Mellitus Tipo 2

Fueron objetivos de este estudio: caracterizar a la polifarmacia entre portadores de Diabetes Mellitus tipo 2 (DM2) y correlacionar la polifarmacia y el numero de complicaciones de la DM2 con indicadores de depresion (Inventario de Depresion de Beck [IDB] y cortisol urinario [CORT]). La muestra fue integrada por 40 pacientes de la Liga de Diabetes del HCFM-USP evaluados respecto de los indicadores de depresion (CORT e IDB) y tambien en cuanto a la practica de polifarmacia y numero de complicaciones de la DM2. Los resultados mostraron que los medicamentos utilizados fueron: antidiabeticos orales, insulinas, antihipertensivos, diureticos, antilipemiantes y tromboliticos. Dentro del grupo estudiado, 75% de los pacientes utilizaban diariamente entre 5 y 8 medicamentos, un 12,5% de la muestra hacia uso de 8 medicamentos/dia o mas; todos hicieron como minimo tres tomas diarias, el 60% presentaba entre 1 y 3 complicaciones de la DM2 y el 22,5% presentaba 3 o mas. La correlacion entre los indicadores de depresion (IDB y CORT) y el numero de medicamentos y de complicaciones de la DM2 no fue estadisticamente significativa. Sin embargo, hubo correlacion positiva entre CORT y la cantidad de tomas diarias de medicamentos (Spearman, r=0.319, p=0.019).The objectives of this study were: to characterize the polipharmacy in subjects with type 2 diabetes mellitus (DM2) and to verify the correlation between polipharmacy and number of medications for DM2 complications with depression indicators (Beck Depression inventory (BDI) and urinary cortisol (CORT) levels). A sample composed of 40 patients with DM2 from the Diabetes League of HCFM-USP was analyzed for depression indicators (CORT and BDI) in addition to evaluation for polipharmacy and number of DM2 complications. The results showed oral hypoglycemic agents, insulins, antihypertensives, diuretics, lipid-lowering drugs and thrombolytics are the most frequent medications used. In this sample, 75% used from 5 to 8 medicines daily and 12.5% used more than eight medicines/day; all of them used to take each medication at least 3 times daily. Between 1 and 3 DM2 complications were observed in 60% of the individuals and 22.5% showed more than 3 DM2 complications. No significant correlations were observed between depression indicators (BDI and CORT), number of medications and DM2 complications. However, positive correlation was observed between CORT and daily frequency of medication (Spearman, r = 0.319, p = 0.019).

Depressão, cortisol urinário e perfil sócio-demográfico de portadores de diabetes mellitus tipo 2

O objetivo deste estudo foi investigar a relacao entre indicadores de depressao e perfil socio-demografico de portadores de Diabetes Mellitus tipo 2 (DM2).A avaliacao socio-demografica foi conduzida em amostra composta por 40 pacientes na Liga de Diabetes (HC-FMUSP).Os indicadores de depressao foram investigados a partir do Inventario de Depressao de Beck (IBD) em associacao com cortisol urinario (CORT).Os resultados mostraram que individuos portadores de DM2 com alta escolaridade, baixo poder aquisitivo individual e familiar e com historia de rompimento de relacao conjugal estavel estao mais propensos a sintomas de depressao.

The relationship between polipharmacy, chronic complications and depression in individuals with Type 2 Diabetes Mellitus

Fueron objetivos de este estudio: caracterizar a la polifarmacia entre portadores de Diabetes Mellitus tipo 2 (DM2) y correlacionar la polifarmacia y el numero de complicaciones de la DM2 con indicadores de depresion (Inventario de Depresion de Beck [IDB] y cortisol urinario [CORT]). La muestra fue integrada por 40 pacientes de la Liga de Diabetes del HCFM-USP evaluados respecto de los indicadores de depresion (CORT e IDB) y tambien en cuanto a la practica de polifarmacia y numero de complicaciones de la DM2. Los resultados mostraron que los medicamentos utilizados fueron: antidiabeticos orales, insulinas, antihipertensivos, diureticos, antilipemiantes y tromboliticos. Dentro del grupo estudiado, 75% de los pacientes utilizaban diariamente entre 5 y 8 medicamentos, un 12,5% de la muestra hacia uso de 8 medicamentos/dia o mas; todos hicieron como minimo tres tomas diarias, el 60% presentaba entre 1 y 3 complicaciones de la DM2 y el 22,5% presentaba 3 o mas. La correlacion entre los indicadores de depresion (IDB y CORT) y el numero de medicamentos y de complicaciones de la DM2 no fue estadisticamente significativa. Sin embargo, hubo correlacion positiva entre CORT y la cantidad de tomas diarias de medicamentos (Spearman, r=0.319, p=0.019).The objectives of this study were: to characterize the polipharmacy in subjects with type 2 diabetes mellitus (DM2) and to verify the correlation between polipharmacy and number of medications for DM2 complications with depression indicators (Beck Depression inventory (BDI) and urinary cortisol (CORT) levels). A sample composed of 40 patients with DM2 from the Diabetes League of HCFM-USP was analyzed for depression indicators (CORT and BDI) in addition to evaluation for polipharmacy and number of DM2 complications. The results showed oral hypoglycemic agents, insulins, antihypertensives, diuretics, lipid-lowering drugs and thrombolytics are the most frequent medications used. In this sample, 75% used from 5 to 8 medicines daily and 12.5% used more than eight medicines/day; all of them used to take each medication at least 3 times daily. Between 1 and 3 DM2 complications were observed in 60% of the individuals and 22.5% showed more than 3 DM2 complications. No significant correlations were observed between depression indicators (BDI and CORT), number of medications and DM2 complications. However, positive correlation was observed between CORT and daily frequency of medication (Spearman, r = 0.319, p = 0.019).

Depression, urinary cortisol and social demographics characteristics in subjects with type 2 diabetes mellitus

O objetivo deste estudo foi investigar a relacao entre indicadores de depressao e perfil socio-demografico de portadores de Diabetes Mellitus tipo 2 (DM2).A avaliacao socio-demografica foi conduzida em amostra composta por 40 pacientes na Liga de Diabetes (HC-FMUSP).Os indicadores de depressao foram investigados a partir do Inventario de Depressao de Beck (IBD) em associacao com cortisol urinario (CORT).Os resultados mostraram que individuos portadores de DM2 com alta escolaridade, baixo poder aquisitivo individual e familiar e com historia de rompimento de relacao conjugal estavel estao mais propensos a sintomas de depressao.

Relación entre polifarmacia, complicaciones crónicas y depresión en portadores de Diabetes Mellitus Tipo 2

Fueron objetivos de este estudio: caracterizar a la polifarmacia entre portadores de Diabetes Mellitus tipo 2 (DM2) y correlacionar la polifarmacia y el numero de complicaciones de la DM2 con indicadores de depresion (Inventario de Depresion de Beck [IDB] y cortisol urinario [CORT]). La muestra fue integrada por 40 pacientes de la Liga de Diabetes del HCFM-USP evaluados respecto de los indicadores de depresion (CORT e IDB) y tambien en cuanto a la practica de polifarmacia y numero de complicaciones de la DM2. Los resultados mostraron que los medicamentos utilizados fueron: antidiabeticos orales, insulinas, antihipertensivos, diureticos, antilipemiantes y tromboliticos. Dentro del grupo estudiado, 75% de los pacientes utilizaban diariamente entre 5 y 8 medicamentos, un 12,5% de la muestra hacia uso de 8 medicamentos/dia o mas; todos hicieron como minimo tres tomas diarias, el 60% presentaba entre 1 y 3 complicaciones de la DM2 y el 22,5% presentaba 3 o mas. La correlacion entre los indicadores de depresion (IDB y CORT) y el numero de medicamentos y de complicaciones de la DM2 no fue estadisticamente significativa. Sin embargo, hubo correlacion positiva entre CORT y la cantidad de tomas diarias de medicamentos (Spearman, r=0.319, p=0.019).The objectives of this study were: to characterize the polipharmacy in subjects with type 2 diabetes mellitus (DM2) and to verify the correlation between polipharmacy and number of medications for DM2 complications with depression indicators (Beck Depression inventory (BDI) and urinary cortisol (CORT) levels). A sample composed of 40 patients with DM2 from the Diabetes League of HCFM-USP was analyzed for depression indicators (CORT and BDI) in addition to evaluation for polipharmacy and number of DM2 complications. The results showed oral hypoglycemic agents, insulins, antihypertensives, diuretics, lipid-lowering drugs and thrombolytics are the most frequent medications used. In this sample, 75% used from 5 to 8 medicines daily and 12.5% used more than eight medicines/day; all of them used to take each medication at least 3 times daily. Between 1 and 3 DM2 complications were observed in 60% of the individuals and 22.5% showed more than 3 DM2 complications. No significant correlations were observed between depression indicators (BDI and CORT), number of medications and DM2 complications. However, positive correlation was observed between CORT and daily frequency of medication (Spearman, r = 0.319, p = 0.019).

Depresion, el cortisol urinario y perfil sociodemografico em portadores de diabetes mellitus tipo 2

O objetivo deste estudo foi investigar a relacao entre indicadores de depressao e perfil socio-demografico de portadores de Diabetes Mellitus tipo 2 (DM2).A avaliacao socio-demografica foi conduzida em amostra composta por 40 pacientes na Liga de Diabetes (HC-FMUSP).Os indicadores de depressao foram investigados a partir do Inventario de Depressao de Beck (IBD) em associacao com cortisol urinario (CORT).Os resultados mostraram que individuos portadores de DM2 com alta escolaridade, baixo poder aquisitivo individual e familiar e com historia de rompimento de relacao conjugal estavel estao mais propensos a sintomas de depressao.

Correlation between urine cortisol and scores on the Beck Depression inventory in patients with type 2 diabetes

Objective: To determ ine th e r e1ati onship between urinary co r tiso 1 an d sco res on the Beck D epr essi on Inven tor y in type 2 diabe tics. Methods: The sam p1e co nsisted of 40 p atien ts wi th type 2 diabetes fr om th e diabetes co n tro 11eague of the disc ip line of endocrinology of the H CFM-U SP. Measures consisted o f uri n ary cortiso 1 an d dep ression symptoms using the B eck Depressio n In ven tor y. Results: The B eck Depression Inven tory h ad a Cro nbachs alpha of 0.92. T here was a statistic ally sign ificant co rrelation b etw een ur inary cortiso 1 and sco res on th e B eck Depression Inven tor y (Spearman r = 0.52, P < .001). Conclusions: The B eck D ep ressi on Inven tor y was fo u n d to b e a reliab1e in di cator of de pressive symptoms in p atients w ith typ e 2 diabetes. Urine cortiso 1 is associa te d with th e presence of dep ressive symptoms.

Correlação entre Inventário de Depressão de Beck e cortisol urinário em diabéticos tipo 2

Objective: To determ ine th e r e1ati onship between urinary co r tiso 1 an d sco res on the Beck D epr essi on Inven tor y in type 2 diabe tics. Methods: The sam p1e co nsisted of 40 p atien ts wi th type 2 diabetes fr om th e diabetes co n tro 11eague of the disc ip line of endocrinology of the H CFM-U SP. Measures consisted o f uri n ary cortiso 1 an d dep ression symptoms using the B eck Depressio n In ven tor y. Results: The B eck Depression Inven tory h ad a Cro nbachs alpha of 0.92. T here was a statistic ally sign ificant co rrelation b etw een ur inary cortiso 1 and sco res on th e B eck Depression Inven tor y (Spearman r = 0.52, P < .001). Conclusions: The B eck D ep ressi on Inven tor y was fo u n d to b e a reliab1e in di cator of de pressive symptoms in p atients w ith typ e 2 diabetes. Urine cortiso 1 is associa te d with th e presence of dep ressive symptoms.

Correlación entre el inventario de Depresión de Beck y el cortisol urinario en diabeticos tipo 2

Objective: To determ ine th e r e1ati onship between urinary co r tiso 1 an d sco res on the Beck D epr essi on Inven tor y in type 2 diabe tics. Methods: The sam p1e co nsisted of 40 p atien ts wi th type 2 diabetes fr om th e diabetes co n tro 11eague of the disc ip line of endocrinology of the H CFM-U SP. Measures consisted o f uri n ary cortiso 1 an d dep ression symptoms using the B eck Depressio n In ven tor y. Results: The B eck Depression Inven tory h ad a Cro nbachs alpha of 0.92. T here was a statistic ally sign ificant co rrelation b etw een ur inary cortiso 1 and sco res on th e B eck Depression Inven tor y (Spearman r = 0.52, P < .001). Conclusions: The B eck D ep ressi on Inven tor y was fo u n d to b e a reliab1e in di cator of de pressive symptoms in p atients w ith typ e 2 diabetes. Urine cortiso 1 is associa te d with th e presence of dep ressive symptoms.