Alexandre da Silva Polydoro

Efeitos da dieta proteica na cicatrização de fraturas distais de fêmur imobilizadas com pinos intramedulares em cão

No presente experimento vinte caes sem raca definida, pesando em media 6kg, com idade variando entre 4 e 12 anos, vindos do Bioterio Central da Universidade Federal de Santa Maria (UFSM), foram distribuidos em dois grupos com 10 animais, cada grupo dividido em dois subgrupos com 5 caes, denominados 1A, 1B, 2A e 2B. Os animais do grupo 1 receberam tratamento por 90 dias, e os do grupo 2 por 60 dias apos a cirurgia. O subgrupo A correspondem a tratamento com racao crescimento contendo 27% de proteina bruta e o subgrupo B racao manutencao com 21% de proteina bruta. Todos os caes sofreram fratura distal de femur, experimental, reduzidas com dois pinos intramedulares, introduzidos atraves da superficie articular da troclea. Os caes ficaram confinados em canis individuais ate a remocao dos pontos e em canis comuns para no maximo 5 caes ate o termino do experimento. Foi feita avaliacao clinica, radiografica e histologica da evolucao da cicatrizacao ossea a qual demonstrou que o tratamento com racao com maior teor de proteina proporcionou melhor regeneracao e que a tecnica de osteossintese utilizada manteve estabilidade na linha de fratura.

Subarachnoidally administered hyperbaric morphine, buprenorphine, methadone, and 10% dextrose on cardiopulmonary function and behavior in horses

The study was done to compare the heart rate, arterial blood pressure, arterial blood gases, respiratory rate, body temperature, and behavior after subarachnoid administration of hyperbaric morphine (MorphineD10), buprenorphine (BuprenorphineD10), methadone (Methadone D10), and 10% dextrose (D10) in conscious horses. Six adult horses were studied. Treatments were administered into the lombo-sacral subarachnoid space through an epidural catheter, MorphineD10 at 0.01mg kg -1 , BuprenorphineD10 at 0.001mg kg -1 , MethadoneD10 at 0.01mg kg -1 , and 10% dextrose as a control group. The results showed that there are minimum changes in heart and respiratory rate, blood gases, blood pressure, and body temperature after subarachnoid administration of hyperbaric opioids in horses. No sedation and nor motor impairment or behavioral changes occur.

Confecção de um modelo experimental in vitro do espaço subaracnóide eqüino para teste de opióides hiperbáricos

Com o objetivo de avaliar as caracteristicas de distribuicao de agentes hiperbaricos no liquido cerebro-espinhal (LCE) equino, e apresentado um modelo in vitro do espaco subaracnoide confeccionado em policloreto de vinila (PVC) transparente, no qual se adaptou um cateter para a infusao continua de glicose a 10%, morfina hiperbarica, buprenorfina hiperbarica e metadona hiperbarica marcadas com azul de metileno para permitir a visualizacao da distribuicao destas substâncias no LCE. Avaliaram-se a distância alcancada pelos diferentes agentes minuto a minuto e a forma de distribuicao dos mesmos. Todas as substâncias testadas mostraram comportamento de distribuicao vertical a partir da extremidade do cateter, quando se deu o inicio da migracao cranial no LCE, sendo que o avanco maximo registrado foi aos 15 minutos apos o termino da infusao, com migracao de 15cm para glicose a 10%, 13cm para a morfina hiperbarica, 18cm para a buprenorfina hiperbarica e 17cm para a metadona hiperbarica. O modelo proposto mostrou-se eficiente para a avaliacao do comportamento fisico dos agentes hiperbaricos no interior do espaco subaracnoide, oferecendo a possibilidade de teste de substâncias a serem utilizadas pela via subaracnoide de cavalos.

Implante de placa de silicone na substituição parcial da parede traqueal em caninos

Six dogs were submitted to an operation to test the viability of sylicon slab in partial replecement of tracheal wall. These animais were anesthetized and had removed a third part with compatible dimension of the circunference of three tracheal rings at mid cervical region. At this place a sylicon slab was implanted and fixed to the surrounding tracheal cartilage. The dogs were observed during thirty days. At post morten, they were evalueted by gross and microscopic examination. It was detected the tissue replacement and the growing of the epithelium.

ANESTESIA EM EQÜINOS COM DETOMIDINA E TILETAMINA-ZOLAZEPAM

SUMMARY Six horses were intravenous anesthetized with 1% detomidine hydrocloride (0.03mg/kg) and the association 5% tiletamine-zolazepam (1mg/kg). The time to get lateral recumbency, time in lateral recumbency and time to stand position were recorded. Heart and respiratory rate, rectal temperature, arterial pH, PCO2 PO2, HCO3, SATO2 and base excess were measured before sedation, during anesthetic procedure and after the horses to be in the stand position. Two horses were submitted to surgical procedures. The mean time to get lateral recumbency was 53.80 ± 9.06 seconds. The mean time in lateral recumbency was 28.50 ± 5.05 minutes and the mean time to stand was 39.16 ± 4.59 minutes. Arterial hemogasometric analysis demonstrated hypoxemia while cardiorespiratory rates and rectal temperature remained stable.

First report on spinal hyperbaric opioids in horses

This study is the first to report the use of spinal hyperbaric opioids in horses injected through a lumbar-sacral subarachnoid catheter. The injection of hyperbaric subarachnoid morphine and methadone produced short term intense analgesia over the dermatomes of the perineal, sacral, lumbar, and thoracic areas without cardiorespiratory depression, ataxia or central nervous system excitement. The technique involves the use of 10% dextrose as a hyperbaric solvent producing an average hyperbaric solution with a specific gravity of 1030. The use of spinal hyperbaric opioids in horses can be recommended for short term moderate to severe pain management in this species.

Fixação externa em fratura completa de metacarpo em potros

The fracture healing in equine legs is a complex process due to species characteristics. Based in previous biomechanical study ten horses had iatrogenic metacarpal fractures reduced by external bone fixation. Each animal was evaluated by clinical, laboratorial and radiografic examination till complete recovery. No significant complication were observed, except one animal which was submitted to euthanasia. The method offers appropriate stability for bone healing.

Avaliação comparativa entre o besilato de atracúrio e o cloreto de alcurônio sobre a frequência cardíaca e a ventilometria de cães anestesiados com halotano

Twenty dogs for the surgical-anaesthetic routine of the Veterinary Hospital of Federal University of Santa Maria - Brazil were divided in two groups, I and II, and submitted to neuromuscular block with atracurium besylate 0.5mg/kg (I) or alcuronium chloride 0.1mg/kg (II). Ventilometry. heart rate and the time for reversion of the blockage were evaluated in group I. Reversal of relaxation in group II was carried with neostigmine preceded by atropine. The results demonstrated a reduction in tidal volume for both groups in the reversion of the blockage, with statistical significance between the groups 20 minutes after reversion. Reduction in heart rate was detected after induction at 30 minutos after established the muscle relaxation. The mean time of neuromuscular blockage with atracurium besylate was 49.07 ± 12.67 minutes.

Avaliação da função renal através da densidade urinaria e dosagem sérica de uréia e creatinina na aflatoxicose experimental em cães

The objective of the present work was to evaluate plasma levels of urea and creatinine and urine density in dogs using experimentally induced aflatoxicosis. Fourteen adult mongrel dogs (7 males and 7 females), weighing 6.7 ± l.96kg were treated with oral aflatoxin (67/µg/kg/day) during 9 days. Three control blood and urine samples were collected before the begining of experimental trial. Then starting on the 5th day of treatment, another 4 samples were collected with 5 day intervals. The results showed that aflatoxin at the dosage used produced clinical signs of intoxication, which later were confirmed by histopathology. However, no alteration in the renal profile could be detected by standard clinical pathology.