Alf Torp
Lund University
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Featured researches published by Alf Torp.
Brain Research Bulletin | 1982
Bengt Falck; Nils-Åke Hillarp; G. Thieme; Alf Torp
The reaction under mild conditions between formaldehyde and phenylalanine and phenylethylamine derivatives has been studied. When the amines included in a dried protein film were exposed to formaldehyde vapour a very intense green to yellow fluorescence was given only by those that as well as being primary amines also have hydroxyl groups at the 3 and 4 positions (3,4-dihydroxyphenylalanine, dopamine, noradrenaline). The 3-OH group seems to be essential for the reaction. The catechol amines, which are secondary amines (adrenaline, epinine), gave a much weaker fluorescence that developed more slowly. The results obtained on further examination of the reaction favour the view that the amines primarily condense with formaldehyde to 1,2,3,4-tetrahydroisoquinolines which are involved in a secondary reaction to become highly fluorescent and at the same time insoluble. This secondary reaction may be a binding to protein, an oxidation with the formation of double bonds in the heterocyclic ring, or both.
Journal of Molecular and Cellular Cardiology | 1979
Henrik Klem Thomsen; Alf Torp
Abstract Twenty-three myocardial biopsies from 22 patients with various cardiological diseases were examined by light and electron microscopy. The amount of fibrosis, endocardial thickening, “whorling of myofibers”, “irregular running of myofibers”, fat infiltration and lipofuscein granules were compared to cardiological parameters such as the function group of the patients, cardiac index, stroke index and the pulmonary capillary wedge pressure. The histological grading showed a weak correlation to the function group of the patients and the pulmonary capillary wedge pressure, but not to the cardiac index or stroke index. While patients with an almost normal heart function had a normal histology, both normal and abnormal histology were seen in patiens with severe heart disease. It was not possible to relate any morphological changes in the myocardium, neither at the light microscopical nor at the ultrastructural level to specific heart diseases as for example primary or alcoholic cardiomyopathy. However, severe contraction artefacts disturbed both the light microscopical and especially the ultrastructural evaluation of the specimens. This problem is discussed and in order to diminish the risk of misinterpretation of myocardial biopsy specimens, recommendations are given with regard to fixation, mincing and embedding of the specimens as well as to the evaluation of both the light microscopic slides and the ultrathin sections.
Pharmacology | 1961
B. Falck; Alf Torp
Pharmacology | 1962
Bengt Falck; Alf Torp
Pharmacology | 1961
Alf Torp
Pharmacology | 1961
Arvid Carlsson; Bengt Falck; Nils-Åke Hillarp; G. Thieme; Alf Torp
Acta Medica Scandinavica | 2009
Pavo Hedner; Alf Rausing; Karin Steen; Alf Torp
Acta Medica Scandinavica | 2009
Jörgen Malmquist; Erik Trell; Alf Torp; Clas Lindström
Acta Medica Scandinavica | 2009
K. F. Aronsen; Alf Torp; Jan Waldenström
Acta Medica Scandinavica | 2009
Per Belfrage; Bengt W. Johansson; Alf Torp; Björn Åkesson