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Alfonso Tramontano

Scripps Research Institute

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Featured researches published by Alfonso Tramontano.

Trends in Biochemical Sciences | 1987

Antibodies as enzymes

Richard A. Lerner; Alfonso Tramontano

Abstract Enzymes may act as catalysts because they are more closely complementary to the transition state than to the substrate or product of a reaction. Monoclonal antibodies were raised to synthetic analogs of an esterolytic transition state. As predicted, some of these antibodies had catalytic activity.

Science | 1987

A stereospecific cyclization catalyzed by an antibody

Andrew D. Napper; Stephen J. Benkovic; Alfonso Tramontano; Richard A. Lerner

Proceedings of the National Academy of Sciences of the United States of America | 1986

Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen

Alfonso Tramontano; Kim D. Janda; Richard A. Lerner

Journal of the American Chemical Society | 1988

Antibody catalysis approaching the activity of enzymes

Alfonso Tramontano; Adrian A. Ammann; Richard A. Lerner

Journal of Biological Chemistry | 1992

Peptidolytic monoclonal antibody elicited by a neuropeptide

Sudhir Paul; Mei Sun; Rustom Mody; Hemant K. Tewary; Paul M. Stemmer; Richard Massey; Teresa Gianferrara; Sanjiv Mehrotra; Thomas Dreyer; Morton Meldal; Alfonso Tramontano

Journal of the American Chemical Society | 1988

Antibody catalysis of bimolecular amide formation

Kim D. Janda; Richard A. Lerner; Alfonso Tramontano

Archive | 1984

Molecules with antibody combining sites that bind to hydrolytic transition states

Alfonso Tramontano; Richard A. Lerner

International Journal of Peptide and Protein Research | 2009

Spontaneous hydrolysis of vasoactive intestinal peptide in neutral aqueous solution

Rustom Mody; Alfonso Tramontano; Sudhir Paul

Journal of the American Chemical Society | 1989

Antibody-catalyzed redox reaction

N. Janjic; Alfonso Tramontano

Methods in Enzymology | 1989

Production of antibodies that mimic enzyme catalytic activity.

Alfonso Tramontano; Diane M. Schloeder

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Richard A. Lerner

Scripps Research Institute

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Andrew D. Napper

Pennsylvania State University

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Kim D. Janda

Scripps Research Institute

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Stephen Benkovic

Scripps Health

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N. Janjic

Scripps Research Institute

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Rustom Mody

University of Nebraska Medical Center

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Sudhir Paul

University of Texas Health Science Center at Houston

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Adrian A. Ammann

Scripps Research Institute

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D. Schloeder

Scripps Research Institute

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Diane M. Schloeder

Scripps Health

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