Alfred E. Wilhelmi

Renal Carbonic Anhydrase

Summary Carbonic anhydrase is present in significant concentrations in the cortex of cat, dog and rat kidneys.

Metabolic changes associated with hemorrhage.

The study of the dynamics of the circulatory system necessarily takes first place in the physiology of hemorrhage. I t has led to the dcvelopment of therapeutic measures which, when applied in good time, can bring about recovery in many instances after severe hemorrhage associated with profound shock. The study of metabolism after hemorrhage has as its principal objective the solution of problems raised by the limitations of the present therapeutic methods. This solution has to be based on an understanding of the metabolic changes accompanying, and perhaps responsible for, the so-called “irreversible” state of shock. One such change, the production of vasodepressor material by the anoxic ,/.

Respiration of Heart Muscle Slices from Rats in the Terminal Stage of Hemorrhagic Shock.

Summary The rate of oxygen uptake of heart muscle slices from rats in the terminal stages of prolonged severe hemorrhagic shock is significantly less than normal in the absence of substrate. In the presence of pyruvate (0.02 M) the rate of oxygen uptake is increased, but is still less than the normal rate. There is, therefore, no conclusive evidence of impaired ability of the heart muscle to oxidize pyruvate in these circumstances.