Alicia J. Johnson

Do Ion Concentrations after Metal-on-Metal Hip Resurfacing Increase Over Time? A Prospective Study

Thirteen male and five female patients received a Conserve Plus hip resurfacing and prospectively provided blood samples to measure cobalt and chromium levels for up to 11 years. Trends in metal levels over time in unilateral and bilateral patients were studied. A multi-variate regression model was used to account for potential covariates. For unilaterals over all time intervals, the median Serum Cobalt level (CoS) was 1.06 μg/L, while the median Serum Chromium level (CrS) was 1.58 μg/L. For bilaterals, the median post operative CoS was 2.80 μg/L, while the median CrS was 5.80 μg/L. Metal levels increased within the first year then decreased and stabilized. These results show that serum metal levels in well-functioning implants can be low and do not increase with time.

The Results of Metal-On-Metal Hip Resurfacing in Patients Under 30 Years of Age

Degenerative hip conditions most commonly affect older patients. However, many cases occur in younger patients. Total hip arthroplasty is the conventional approach; however, hip resurfacing is a viable option. Fifty-three metal-on-metal resurfacings in 46 patients under age 30 were performed. Patients had a variety of etiologies, and were followed clinically and radiographically with mean follow-up of 98.2 months. Clinical scores and x-rays were compared pre-operatively and post-operatively. The last follow-up SF-12 and UCLA scores significantly improved post-operatively (P<0.0001). Range of motion scores also improved (P<0.001), and the mean Harris Hip Score was 88. There were 6 revisions. The Kaplan-Meier survivorship estimate at 8 years was 95%. Metal-on-metal hip resurfacing appears to be an effective procedure for younger patients. Longer-term data are needed for confirmation.

Results of Conserve Plus® Metal-On-Metal Hip Resurfacing for Post-Traumatic Arthritis and Osteonecrosis:

The safety and efficacy of metal-on-metal surface arthroplasty in post-traumatic arthritis and post-traumatic osteonecrosis (PT OA and PT ON) cases has not previously been thoroughly investigated. This study compared the outcomes of metal-on-metal hip resurfacing (HR) in patients performed for an indication of OA secondary to trauma to compared to PT ON. Metal-on-metal resurfacing arthroplasties were performed on 62 hips, 43 with PT OA and 19 with PT ON with secondary osteoarthritis. There were 51 males and 11 females. All patients were followed up clinically and radiographically with a mean follow-up of 87.2 months. Clinical outcome scores, survivorship, and radiographs were compared between the PT OA and PT ON group. The clinical outcomes for the PT ON and PT OA groups were similar with a survival rate of 95% (95% CI 82.1% to 98.8%) for the PT OA group alone at 8 years and 91% for those with PT OA with ON at 8 years (95% CI 50.8%-98.7%). The Kaplan-Meier survivorship curves for the cohorts of PT OA and PT ON patients were not statistically significantly different (Log rank, p=0.6036). Metal-on-metal hip resurfacing appears to be a safe and effective procedure for the treatment of both post-traumatic osteoarthritis and osteonecrosis.

Metal Ion Levels in Total Hip Arthroplasty Versus Hip Resurfacing

Recent studies suggest that the tapered interface between stem and femoral head may be a substantial source of cobalt and chromium ion release after metal-on-metal (MOM) total hip arthroplasty (THA). This study compared patient ion levels after MOM hip resurfacing (HR) and MOM THA performed with identical acetabular components. 110 HRs were compared with 22 THAs. All had well-oriented components, unilateral implants, and serum ion studies beyond one year post-operatively. The HR groups median cobalt value was 1.11 μg/L vs. 2.86 μg/L for the THA patients. The HR groups median chromium value was 1.49 μg/L vs. 2.94 μg/L for THA. Significantly higher THA ion levels suggest a source of ions other than the MOM bearing itself.

Do hardened femoral heads reduce blood metal ion concentrations after hip resurfacing

Background Elevated cobalt and chromium ion concentrations have been associated with the use of metal-on-metal bearings in hip arthroplasty. The use of a differential hardness bearing may reduce metal particle release. The aim of our study was to compare circulating cobalt (Co) and chromium (Cr) ion levels between patients treated with a standard all ‘as-cast’ heat treated bearing and a differential hardness bearing. Materials and methods One hundred and thirty-two patients implanted with unilateral hip resurfacing arthroplasties and having had blood metal ion studies performed between one and six years after surgery were retrospectively selected. There were 73 patients in the standard all ‘as cast’ heat treated bearing group (group 1) and 59 in the differential hardness bearing group (group 2). Results Clinical and quality of life scores were comparable between groups. The median Co in group 1 was 1.01 µg/L and 1.23 µg/L in group 2 (p = 0.0566). The median Cr in group 1 was 1.60 µg/L and 1.34 µg/L in group 2 (p = 0.0505). Conclusion Compared with conventional heat-treated CoCr bearings, differential hardness metal-on metal bearings do not confirm in vivo the hopes of a substantial reduction in circulating metal ions concentrations suggested by in vitro wear studies.

Childhood development after maternal metal-on-metal hip resurfacing

Metal-on-metal (MoM) hip resurfacing has been used in many young, active patients, including women of childbearing age. While ion levels have been measured in mothers with MoM hip resurfacing and their babies, little is known about how these ions affect child development. Out of 1300, MoM hip resurfacing surgeries, we had 48 women of childbearing age (defined as 40 years of age or younger at the time of surgery). These women were contacted to see if they had had pregnancies after their surgery, and those who had were sent surveys asking about their pregnancies and the development of their children. Eleven women reported pregnancies, and eight returned the surveys. There were no significant differences between women with pregnancies and those without pregnancies in any demographic or clinical measures. From the eight women who completed surveys, there were seventeen pregnancies resulting in fourteen births. There were complications in three of the births resulting in two premature births, but no children were born with birth defects. Overall, the children appear to be developing normally. Based on this unique data, we do not feel that MoM hip resurfacing is contraindicated for women of childbearing age, but power analyses show that we cannot draw conclusive results from our sample. We recommend that other groups publish their own data to allow us to generate sufficient sample sizes to draw meaningful conclusions.