Almut F. Molzberger
German Sport University Cologne
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Featured researches published by Almut F. Molzberger.
Molecular Nutrition & Food Research | 2012
Almut F. Molzberger; Günter Vollmer; Torsten Hertrampf; Sabine E. Kulling; Patrick Diel
SCOPE Exposure scenarios during different stages of development of an organism are discussed to trigger adverse and beneficial effects of isoflavones (ISO). The aim of this study was to investigate how in utero and postnatal ISO exposure modulates the estrogen sensitivity of the mammary gland and to identify the underlying molecular mechanisms. METHODS AND RESULTS Therefore, rats were exposed to either ISO-free (IDD), ISO-rich (IRD) or genistein-rich diet (GRD), up to young adulthood. Proliferative activity (PCNA expression) in the mammary gland at different ages and the estrogen sensitivity of the mammary gland to estradiol (E₂) or genistein (GEN) in adult ovariectomized animals was determined and compared with different treatments. Treatment with E₂ resulted in a significant lower proliferative and estrogenic response of the mammary gland in IRD and GRD compared with IDD. This correlates to a change in the gene expression pattern and a decrease in the ratio of estrogen receptor alpha (ERα) beta (ERβ CONCLUSIONS Our results provide evidence that in utero and postnatal exposure to a diet rich in ISO but also to GEN reduces the sensitivity of the mammary gland toward estrogens and support the hypothesis that in utero and postnatal ISO exposure reduces the risk to develop breast cancer.
Toxicology Letters | 2009
Torsten Hertrampf; C. Ledwig; Sabine E. Kulling; Almut F. Molzberger; Oliver Zierau; Günter Vollmer; S. Moors; Gisela H. Degen; Patrick Diel
Effects of isoflavones on estrogen sensitive tissues are discussed controversially. This study was designed to investigate tissue specific effects of an isoflavone exposure through different periods of life in female Wistar rats and to compare the effects of genistein (GEN) to those of mixed dietary isoflavones, GEN and daidzein (DAI). One group received an isoflavone-free diet (IDD), another was fed an isoflavone-rich diet (IRD) and the third group an IDD supplemented with GEN (GEN(d)) prior to mating, throughout pregnancy and up to weaning. The offspring were kept on the respective diets during growth, puberty and adulthood. The weight of the uterus, the height of the uterine and vaginal epithelium, the bone mineral density of the tibia, and the expression of the estrogen sensitive gene CaBP9K in the liver were determined. At d21, the uterine weight, the uterine epithelium and the expression of CaBP9K in the liver were significantly stimulated in GEN(d) animals compared to IDD and IRD. Interestingly, bone mineral density was increased in GEN(d) and in IRD animals. Around puberty (d50) neither uterine wet weights nor trabecular bone density differed significantly among the isoflavone groups and the IDD control. At d80 no significant differences in uterine weight were observed among IDD, GEN(d) and IRD animals. However, bone mineral density was increased in GEN(d) and IRD animals. In summary, our results demonstrate that lifelong dietary exposure to isoflavones can affect estrogen sensitive tissues, apparently in a tissue selective manner. With respect to health risk and benefit our data indicate that an increased bone mineral density can be achieved by lifelong exposure to an IRD, which, in contrast to GEN supplementation, does not seem to stimulate the proliferation of the uterine epithelium.
European Journal of Nutrition | 2009
Jan Seibel; Almut F. Molzberger; Torsten Hertrampf; Ute Laudenbach-Leschowski; Patrick Diel
Archives of Toxicology | 2008
Jan Seibel; Almut F. Molzberger; Torsten Hertrampf; Ute Laudenbach-Leschowski; Gisela H. Degen; Patrick Diel
Archives of Toxicology | 2013
Almut F. Molzberger; Sebastian T. Soukup; Sabine E. Kulling; Patrick Diel
Toxicology Letters | 2016
Simone Baechler; Sebastian T. Soukup; Almut F. Molzberger; Sabine E. Kulling; Patrick Diel; Doris Marko
Toxicology Letters | 2011
Simone Baechler; Almut F. Molzberger; Nicole Teller; Patrick Diel; D. Marko
Abstractband zum 48. Wissenschaftlichen Kongress: Proceedings of the German Nutrtition Society - Volume 15 | 2011
Almut F. Molzberger; Günter Vollmer; Sabine E. Kulling; C.E. Rüfer; Patrick Diel
Abstractband zum 47. Wissenschaftlichen Kongress: Proceedings of the German Nutrtition Society - Volume 14 | 2010
Almut F. Molzberger; Torsten Hertrampf; Günter Vollmer; G.H. Degen; Sabine E. Kulling; Patrick Diel
10th European Congress of Endocrinology | 2008
Patrick Diel; Gisela H. Degen; Thorsten Hertrampf; Claudia Ledwig; S. Moors; Almut F. Molzberger; Olliver Zierau; Günter Vollmer