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Dive into the research topics where Almut F. Molzberger is active.

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Featured researches published by Almut F. Molzberger.


Molecular Nutrition & Food Research | 2012

In utero and postnatal exposure to isoflavones results in a reduced responsivity of the mammary gland towards estradiol

Almut F. Molzberger; Günter Vollmer; Torsten Hertrampf; Sabine E. Kulling; Patrick Diel

SCOPE Exposure scenarios during different stages of development of an organism are discussed to trigger adverse and beneficial effects of isoflavones (ISO). The aim of this study was to investigate how in utero and postnatal ISO exposure modulates the estrogen sensitivity of the mammary gland and to identify the underlying molecular mechanisms. METHODS AND RESULTS Therefore, rats were exposed to either ISO-free (IDD), ISO-rich (IRD) or genistein-rich diet (GRD), up to young adulthood. Proliferative activity (PCNA expression) in the mammary gland at different ages and the estrogen sensitivity of the mammary gland to estradiol (E₂) or genistein (GEN) in adult ovariectomized animals was determined and compared with different treatments. Treatment with E₂ resulted in a significant lower proliferative and estrogenic response of the mammary gland in IRD and GRD compared with IDD. This correlates to a change in the gene expression pattern and a decrease in the ratio of estrogen receptor alpha (ERα) beta (ERβ CONCLUSIONS Our results provide evidence that in utero and postnatal exposure to a diet rich in ISO but also to GEN reduces the sensitivity of the mammary gland toward estrogens and support the hypothesis that in utero and postnatal ISO exposure reduces the risk to develop breast cancer.


Toxicology Letters | 2009

Responses of estrogen sensitive tissues in female Wistar rats to pre- and postnatal isoflavone exposure

Torsten Hertrampf; C. Ledwig; Sabine E. Kulling; Almut F. Molzberger; Oliver Zierau; Günter Vollmer; S. Moors; Gisela H. Degen; Patrick Diel

Effects of isoflavones on estrogen sensitive tissues are discussed controversially. This study was designed to investigate tissue specific effects of an isoflavone exposure through different periods of life in female Wistar rats and to compare the effects of genistein (GEN) to those of mixed dietary isoflavones, GEN and daidzein (DAI). One group received an isoflavone-free diet (IDD), another was fed an isoflavone-rich diet (IRD) and the third group an IDD supplemented with GEN (GEN(d)) prior to mating, throughout pregnancy and up to weaning. The offspring were kept on the respective diets during growth, puberty and adulthood. The weight of the uterus, the height of the uterine and vaginal epithelium, the bone mineral density of the tibia, and the expression of the estrogen sensitive gene CaBP9K in the liver were determined. At d21, the uterine weight, the uterine epithelium and the expression of CaBP9K in the liver were significantly stimulated in GEN(d) animals compared to IDD and IRD. Interestingly, bone mineral density was increased in GEN(d) and in IRD animals. Around puberty (d50) neither uterine wet weights nor trabecular bone density differed significantly among the isoflavone groups and the IDD control. At d80 no significant differences in uterine weight were observed among IDD, GEN(d) and IRD animals. However, bone mineral density was increased in GEN(d) and IRD animals. In summary, our results demonstrate that lifelong dietary exposure to isoflavones can affect estrogen sensitive tissues, apparently in a tissue selective manner. With respect to health risk and benefit our data indicate that an increased bone mineral density can be achieved by lifelong exposure to an IRD, which, in contrast to GEN supplementation, does not seem to stimulate the proliferation of the uterine epithelium.


European Journal of Nutrition | 2009

Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis

Jan Seibel; Almut F. Molzberger; Torsten Hertrampf; Ute Laudenbach-Leschowski; Patrick Diel


Archives of Toxicology | 2008

In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis.

Jan Seibel; Almut F. Molzberger; Torsten Hertrampf; Ute Laudenbach-Leschowski; Gisela H. Degen; Patrick Diel


Archives of Toxicology | 2013

Proliferative and estrogenic sensitivity of the mammary gland are modulated by isoflavones during distinct periods of adolescence

Almut F. Molzberger; Sebastian T. Soukup; Sabine E. Kulling; Patrick Diel


Toxicology Letters | 2016

Topoisomerase poisoning by genistein in the intestine of rats

Simone Baechler; Sebastian T. Soukup; Almut F. Molzberger; Sabine E. Kulling; Patrick Diel; Doris Marko


Toxicology Letters | 2011

Genistein acts as topoisomerase II poison in vivo

Simone Baechler; Almut F. Molzberger; Nicole Teller; Patrick Diel; D. Marko


Abstractband zum 48. Wissenschaftlichen Kongress: Proceedings of the German Nutrtition Society - Volume 15 | 2011

Lifelong and timely restricted pubertal exposure to isoflavones reduces the proliferative response of the mammary gland towards estradiol

Almut F. Molzberger; Günter Vollmer; Sabine E. Kulling; C.E. Rüfer; Patrick Diel


Abstractband zum 47. Wissenschaftlichen Kongress: Proceedings of the German Nutrtition Society - Volume 14 | 2010

Lifelong exposure to isoflavones results in a reduced responsivity of the mammary gland in female rats towards estradiol

Almut F. Molzberger; Torsten Hertrampf; Günter Vollmer; G.H. Degen; Sabine E. Kulling; Patrick Diel


10th European Congress of Endocrinology | 2008

In utero and postnatal exposure to phytoestrogens modulates the bone mineral density of juvenile and adult female wistar rats

Patrick Diel; Gisela H. Degen; Thorsten Hertrampf; Claudia Ledwig; S. Moors; Almut F. Molzberger; Olliver Zierau; Günter Vollmer

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Günter Vollmer

Dresden University of Technology

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Torsten Hertrampf

German Sport University Cologne

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Gisela H. Degen

Technical University of Dortmund

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Jan Seibel

German Sport University Cologne

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S. Moors

Technical University of Dortmund

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D. Marko

University of Vienna

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