Alona Paz

National Multicenter Study of Predictors and Outcomes of Bacteremia upon Hospital Admission Caused by Enterobacteriaceae Producing Extended-Spectrum β-Lactamases

ABSTRACT Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are pathogens that may lead to a spectrum of clinical syndromes. We aimed to identify predictors and outcomes of ESBL bacteremia upon hospital admission (UHA) in a nationwide prospective study. Thus, a multicenter prospective study was conducted in 10 Israeli hospitals. Adult patients with bacteremia due to Enterobacteriaceae diagnosed within 72 h of hospitalization were included. Patients with ESBL producers (cases) were compared to those with non-ESBL producers (controls), and a 1:1 ratio was attempted in each center. A case-control study to identify predictors and a cohort study to identify outcomes were conducted. Bivariate and multivariate logistic regressions were used for analyses. Overall, 447 patients with bacteremia due to Enterobacteriaceae were recruited: 205 cases and 242 controls. Independent predictors of ESBL were increased age, multiple comorbid conditions, poor functional status, recent contact with health care settings, invasive procedures, and prior receipt of antimicrobial therapy. In addition, patients presenting with septic shock and/or multiorgan failure were more likely to have ESBL infections. Patients with ESBL producers suffered more frequently from a delay in appropriate antimicrobial therapy (odds ratio [OR], 4.7; P, <0.001) and had a higher mortality rate (OR, 3.5; P, <0.001). After controlling for confounding variables, both ESBL production (OR, 2.3; P, 9.1) and a delay in adequate therapy (OR, 0.05; P, 0.001) were significant predictors for mortality and other adverse outcomes. We conclude that among patients with bacteremia due to Enterobacteriaceae UHA, those with ESBL producers tend to be older and chronically ill and to have a delay in effective therapy and severe adverse outcomes. Efforts should be directed to improving the detection of patients with ESBL bacteremia UHA and to providing immediate appropriate therapy.

Mycoplasma-associated carditis: Case reports and review

We present 2 cases and examine the developments that occurred in diagnosis, treatment, and outcome of 19 additional patients with mycoplasmal peri- and myocarditis. The mean age of this group was 33 years. The final diagnoses were pericarditis (n = 15), myocarditis (n = 5), and myopericarditis (n = 1); pulmonary involvement was noted in 13 patients. Serology established the diagnosis in 12 cases, and isolation in 9 others. In contrast to previous reviews, an echocardiogram was carried out in all patients, thus enabling pericardiocentesis in 13 patients. Antibiotics were given to 19 patients, including 4 who received a newer macrolide. Three patients were left with long-term sequelae, and 1 patient died. The outcome of Mycoplasma carditis has improved over the years, although a minority of patients may suffer long-term sequelae.

Pseudomonas aeruginosa bacteremia upon hospital admission: risk factors for mortality and influence of inadequate empirical antimicrobial therapy

Pseudomonas aeruginosa is an uncommon cause of bacteremia upon hospital admission (UHA) and the chosen empirical antimicrobial therapy may not cover it appropriately. In a multicenter prospective study conducted in Israel, we evaluated risk factors for in-hospital mortality in patients with P. aeruginosa bacteremia UHA and determined the influence of delay in adequate empirical antimicrobial therapy on patients outcome. Seventy-six adult patients with P. aeruginosa bacteremia within 72 h of hospital admission were included. Demographic, clinical, and treatment data were collected. Microbiological adequacy of empirical therapy was determined. Severe sepsis or septic shock at admission (OR, 21.9; P < 0.001), respiratory or unknown sources of bacteremia (OR, 11.5; P = 0.003), recent hospitalization (OR, 6.2; P = 0.032), and poor functional status (OR, 5.8; P = 0.029) were identified as independent predictors of mortality. Inadequate empirical antimicrobial therapy was marginally associated with increased mortality only among patients who presented with severe sepsis or septic shock (P = 0.051).

Pregnancy-Associated Listeriosis: Clinical Characteristics and Geospatial Analysis of a 10-Year Period in Israel

BACKGROUNDnListeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or a preterm delivery, and the neonate is prone to neonatal sepsis and death.nnnMETHODSnWe created a cohort of all L. monocytogenes cases during 10 years (1998-2007) in Israel, by a comprehensive review of cases in hospitals throughout the country and cases reported to the Ministry of Health.nnnRESULTSnOne hundred sixty-six pregnancy-related listeriosis cases were identified, resulting in a yearly incidence of 5-25 cases per 100 000 births. Presentation associated with fetal demise was more common in the second trimester (55.3%), and preterm labor (52.3%) and abnormal fetal heart rate monitoring (22.2%) were more common in the third trimester (P = .001). Fetal viability was low in the second trimester (29.2%) and much higher (95.3%) in the third trimester. Each additional week of pregnancy increased the survival chance by 33% (odds ratio, 1.331 [95% confidence interval, 1.189-1.489]). A single case of maternal mortality was identified. Listeria monocytogenes serotype 4b was more common in pregnancy-related than in non-pregnancy-related cases (79.5% vs 61.3%, P = .011). Pulsed-field gel electrophoresis analysis suggested that 1 pulsotype is responsible for 35.7% of the pregnancy cases between 2001 and 2007. This clone is closely related to the Italian gastroenteritis-associated HPB2262 and the invasive US Scott A L. monocytogenes strains.nnnCONCLUSIONSnOur survey emphasizes the high rate of pregnancy-related listeriosis in Israel and shows that specific clones might account for this.

High rates of substance abuse among long-term travelers to the tropics: an interventional study.

BACKGROUNDnDrug abuse constitutes a worldwide problem. The purpose of this study was to investigate the characteristics of illicit drug use during long-term travel to the tropics, and to estimate the effects of antidrug brochures provided before travel on the use of drugs during travel.nnnMETHODSnAn interventional study was done on 1,000 travelers to the tropics aged 18 to 30 years. Pretravel brochures explaining the hazards of drug abuse were provided to 500 of them. A control group of 500 travelers did not receive the brochures. Questionnaires exploring drug abuse habits were sent to all travelers after their return.nnnRESULTSnAmong 223 travelers (108 and 115 of the intervention and control groups, respectively) who returned their questionnaires, 82 (36.8%, 95% CI 30.5-43.5%) had experienced illicit drug use during their trip, whereas only 52 of them had tried drugs before (p<0.01). More travelers had used drugs in the Far East (43.3%) than in South America (25.6%, p< 0.01). The strongest predictors of drug abuse were: the compound of female gender and travel to Asia (odds ratio (OR), 4.3), education <or=12 school years (OR 3.5), age <or=25 years (OR 2.7), and no malaria prophylaxis (OR 2.6). The brochures failed to decrease the rate of drug abuse (38.9% vs. 34.8% in the control group, p=NS).nnnCONCLUSIONSnMore than one-third of young Israelis who travel to the tropics use illicit drugs. For many, the trip was their first encounter. Brochures as a sole agent are inadequate, and further means are needed to reduce this alarming trend.

Candida Sepsis Following Transcervical Chorionic Villi Sampling

Background: The use of invasive devices and broad spectrum antibiotics has increased the rate of candidal superinfections.Candida sepsis associated with pregnancy is rare. Candida sepsis following chorionic villi sampling (CVS) has never been reported. Case: A 31-year-old pregnant woman presented with signs of sepsis one day after undergoing transcervical CVS. Blood culture and curettage material yielded C. albicans. She was treated with 400 mg of fluconazole daily for 4 weeks and completely recovered. Conclusion: Candida sepsis should be considered in the differential diagnosis of sepsis following CVS.

Doxycycline desensitization in chronic Q fever—A critical tool for the clinician

We present the case of a 45u2009year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe allergy and she was put on clarithromycin and later moxifloxacin. Failure of both drugs required desensitization to doxycycline with escalating doses. After two-year treatment with doxycycline-hydroxychloroquine combination, complete recovery was declared. Our case highlights the option of doxycycline desensitization when an acute allergic reaction poses an obstacle to optimal treatment.

Acute Ocular Pain following Contact with Electrical Ant's (Wasmannia Auropunctata) Excretions

Background: Ocular injury caused by insect bites or by contact with insects’ excreta is rare. The electrical ant-Wasmannia auropunctata has recently spread to many corners of the globe. Design: A descriptive case report. Results: A 66-year old woman experienced severe, acute ocular pain and conjunctival irritation within minutes following contact with electrical ant. Irrigation of the eye and systemic analgesics alleviated her symptoms after one hour. Conclusions: With the abundance of electrical ants we are bound to see more cases of ocular injury. These injuries, though painful are short-lived, so reassurance, irrigation and analgesics are adequate.