Amador Gonzalez-Angulo

Submicroscopic alterations in capillaries of skeletal muscles in polymyositis

Abstract Electron microscopic changes in capillaries of muscle are described in four patients with polymyositis. Marked thickening and lamination of basement membrane and various degrees of endothelial swelling, to the point of causing obstruction of the lumen, were found when compared to control subjects.

A patient with Wegener's granulomatosis exhibiting unusual clinical and morphologic features

Abstract A patient with Wegeners granulomatosis is presented in whom several unusual manifestations were observed, including cerebral arteritis, an aneurysm of the left vertebral artery resulting from the arteritis, and three pulmonary cavities with unusually thin walls. The focal glomerular changes observed at necropsy showed regression in severity when compared to those seen in two renal biopsy specimens obtained during life. Renal function remained good, and death was attributed to the cerebral arteritis. The value of renal biopsy in establishing the diagnosis is emphasized. Corticosteroid therapy in doses sufficiently large to suppress completely the inflammatory elements of the disease is recommended.

THE ULTRASTRUCTURE OF GANGLIONEUROBLASTOMA. OBSERVATIONS ON NEOPLASTIC GANGLION CELLS.

THE MORPHOLOGY of malignant tumors of sympathetic origin as seen with the light microscope is well known.1-3 The ultrastructure of normal sympathetic ganglion cells a n d their processes have also been described4-18 and their histochemical nature studied.]g These observations a re of great importance to the understanding and interpretation of the ultrastructural changes present i n malignant tumo’rs of sympathetic origin. The purpose of this paper is to report our observations on the morphology of neoplastic ganglion cells in two cases of ganglioneuroblastoma. To our knowledge, no electron microscopic studies of these tumors have been published.

Ultrastructure of muscle in polymyositis

Abstract The present observations on the ultrastructure of muscle fibers in polymyositis offer little basis for classification of different subtypes. Except for the lymphocytic and plasma cell infiltrates seen in a case associated with Sjogrens syndrome, the muscle lesions appeared much the same irrespective of the clinical type of polymyositis or its association with malignancy or some other connective tissue disease.

“Retinal anlage tumor of infancy”: Reportof a case occurring in the anterior fontanel

A benign, rare, melanotic tumor, occurring in infants under 12 months of age, hasbeen variously called “retinal anlage tumor”, “melanotic progonoma” and “melanotic adamantinoma.” Approximately 40 cases have been documented, the majority occurring in the maxilla and mandible. In only a few cases, the tumor was extrafacial. In the present case, the growth occurred in the anterior fontanel. Grossly the tumor was pigmented, and microscopically it was composed of fibrous tissue, cuboidal cells containing melanin pigment, and small cells resembling neuroblasts.

Anomalies of the Origin of Coronary Arteries (Special Reference To Single Coronary Artery)

one type, one or both2 coronary arteries or an accessory branch arise from the pulmonary artery.3, In this condition the patient dies at an early age, usually with myocardial infarction and accompanying dilation and hypertrophy of the heart.s-7 In the other type, the coronary arterial supply is derived exclusively from the aorta, but the origin deviates from the normal pattern. Most cases of single coronary artery belong to this category which is usually of no clinical significance.4, 8, A single coronary artery is defined

Generalized primary amyloidosis: Report of a case with amyloid verrucous valvular lesions and nephrotic syndrome

Abstract 1. 1. A case of generalized primary amyloidosis with congestive heart failure and nephrotic syndrome is reported. Extensive deposits of amyloid were seen in several viscera, including the heart and kidneys. The heart revealed verrucous valvular lesions, and the kidney showed diffuse glomerular involvement. 2. 2. The various types of amyloidosis are discussed, with particular reference to the distribution of the deposits in the heart and kidneys. 3. 3. It is emphasized that amyloidosis should always be considered in the differential diagnosis in cases of cardiac failure and nephrotic syndrome.

Tissue reaction to autologous elastic fibers implanted in the urinary bladder of dogs

Abstract Degenerating elastic fibers are commonly listed as a cause of granulomatous tissue reaction with giant cell formation, such as in the case of temporal (giant cell) arteritis, or in some cases of chronic pulmonary diseases such as tuberculosis, sarcoidosis, pulmonary hemosiderosis, emphysema, etc. The purpose of this study was to determine if implants of autologous elastic fibers in the urinary bladder of dogs invoke granulomatous tissue reaction with giant cell production. Nine dogs were utilized. The elastic tissue was obtained from the abdominal aorta and implanted in the urinary bladder. The animals were killed at intervals of 1, 2, 3, and 4 weeks and 2, 3, 4, 5, and 6 months. At no time during the experiment was there any granulomatous tissue reaction or giant cell formation. It is concluded that, under the conditions of the experiment, autologous aortic elastic fibers implanted in the urinary bladder of dogs do not induce the formation of giant cells or granulomatous tissue reaction.