S. Donald Greenberg

A patient with Wegener's granulomatosis exhibiting unusual clinical and morphologic features

Abstract A patient with Wegeners granulomatosis is presented in whom several unusual manifestations were observed, including cerebral arteritis, an aneurysm of the left vertebral artery resulting from the arteritis, and three pulmonary cavities with unusually thin walls. The focal glomerular changes observed at necropsy showed regression in severity when compared to those seen in two renal biopsy specimens obtained during life. Renal function remained good, and death was attributed to the cerebral arteritis. The value of renal biopsy in establishing the diagnosis is emphasized. Corticosteroid therapy in doses sufficiently large to suppress completely the inflammatory elements of the disease is recommended.

Experimental atherosclerosis in the dog: A morphologic study ☆

Abstract Young mongrel dogs developed atherosclerosis of various degrees in their coronary arteries, aortas, and iliac and caudal arteries when they were fed atherogenic diets containing butter, cholesterol, sodium cholate, thiouracil, and other basal ingredients for the periods of 5 1 2 –16 months. None of the dogs had evidence of arterial occlusion. Grossly, the intimal lesions were most marked in the lower segments of the abdominal aortas. Histologically, the coronary arteries and the aortas revealed subendothelial collections of lipid-laden macrophages mixed with erythrocytes and leucocytes in the early lesions and with connective tissue components in the late lesions. Electron-microscopically, lipid-laden macrophages were closely associated with endothelial cells, appeared to be penetrating the endothelium, and were mixed with smooth muscle cells in the subendothelial space.

Tracheal prosthesis: An experimental study with Marlex☆

Abstract In most cases heavy Marlex mesh will serve as a satisfactory air-way following one-stage replacement of a seven-ring circumferential portion of cervical trachea in the dog. Respiratory epithelium does not regenerate to completely line the prostheses. The mucosa consists of granulation tissue and varying degrees of epithelial regeneration. With time, there is no resolution of the chronic inflammatory reaction; rather, occasionally it becomes more severe.

Generalized primary amyloidosis: Report of a case with amyloid verrucous valvular lesions and nephrotic syndrome

Abstract 1. 1. A case of generalized primary amyloidosis with congestive heart failure and nephrotic syndrome is reported. Extensive deposits of amyloid were seen in several viscera, including the heart and kidneys. The heart revealed verrucous valvular lesions, and the kidney showed diffuse glomerular involvement. 2. 2. The various types of amyloidosis are discussed, with particular reference to the distribution of the deposits in the heart and kidneys. 3. 3. It is emphasized that amyloidosis should always be considered in the differential diagnosis in cases of cardiac failure and nephrotic syndrome.

Variations in ventricular weights of calf hearts at sea level

Abstract In order to provide data on the variations in ventricular weights of calf hearts at sea level, the ratio of right ventricular weight (RVW) to left ventricular weight (LVW) was determined for 21 hearts of normal calves ranging in age from 1 day to 12 months. Hearts of calves less than 5 days of age had a mean RVW LVW of 1.00 (SD = 0.136; SE = 0.078). Twelve 6-month-old calves had RVW LVW of 0.58 (SD = 0.042; SE = 0.012). Six 12-month-old specimens had a mean RVW LVW of 0.59 (SD = 0.012; SE = 0.003). At birth the RVW predominates. At the age of 6 months the adult RVW LVW ratio has been established. These data are quite similar to those previously established for the human.

Tissue reaction to autologous elastic fibers implanted in the urinary bladder of dogs

Abstract Degenerating elastic fibers are commonly listed as a cause of granulomatous tissue reaction with giant cell formation, such as in the case of temporal (giant cell) arteritis, or in some cases of chronic pulmonary diseases such as tuberculosis, sarcoidosis, pulmonary hemosiderosis, emphysema, etc. The purpose of this study was to determine if implants of autologous elastic fibers in the urinary bladder of dogs invoke granulomatous tissue reaction with giant cell production. Nine dogs were utilized. The elastic tissue was obtained from the abdominal aorta and implanted in the urinary bladder. The animals were killed at intervals of 1, 2, 3, and 4 weeks and 2, 3, 4, 5, and 6 months. At no time during the experiment was there any granulomatous tissue reaction or giant cell formation. It is concluded that, under the conditions of the experiment, autologous aortic elastic fibers implanted in the urinary bladder of dogs do not induce the formation of giant cells or granulomatous tissue reaction.

A rapid nonsuture arterial shunt; an experimental study.

arterial shunt which requires less than 90 sec. for either insertion or removal. We feel that such a shunt will be of value in neck surgery with resection of the carotid arteries and in abdominal surgery with resection of the renal arteries. Arterial shunts, both intraluminal and extraluminal, have been studied experimentally for years. Carrel (3), in 1912, used paraffin coated glass and metal tubes of 1.0 cm diameter and 4.5 cm length in an attempt to intubate permanently the descending thoracic aorta of dogs. Apparently there was no clinical application. During the 35 years which followed there was no further significant study of arterial shunts.