Amanda Hudson

Ovarian hormones and propensity to drug relapse: A review

Sex differences have been reported in various phases of substance abuse, including relapse. In general, women show greater propensity to drug relapse than men, owing perhaps to divergent withdrawal experiences and increased reactivity to internal (emotional) and external (drug-associated) cues. Animal research tends to parallel human findings, revealing enhanced reinstatement of drug administration in females than males. Moreover, differences in vulnerability to relapse/reinstatement have been documented in women and female rodents across the ovarian cycles. Thus ovarian hormones seem to play an important role in determining susceptibility to relapse. Indeed, ovarian hormones interact with many of the neural circuits implicated in drug-primed, cue-instigated, and stress-induced relapse. By understanding the effects of ovarian hormones on the neural and behavioral mechanisms of drug relapse, sex differences and cyclical variations in relapse susceptibility can be elucidated and more effective treatment strategies can be explored.

Effects of estrous stage and time of day on prepulse inhibition in female rats

Prepulse inhibition (PPI) of the acoustic startle response is a measure of sensory motor gating, and is affected in various neuropsychiatric disorders. Although PPI has been used extensively to study both the neural effects of such conditions, as well as in the search for animal models, a number of critical issues have been encountered. Published methods for testing PPI vary widely across many parameters, two of the most common being the phase of the light/dark cycle during which the subjects are tested and the inclusion or exclusion of females. While previous research has attempted to clarify the effect of these factors, results for both human and animal studies have often been contradictory. This study investigated the relevance of the estrous cycle and time of day as variables that may influence PPI in adult female Sprague-Dawley rats. Results indicate that PPI is not affected by estrous phase, but may be affected by the time of day of testing, particularly at higher prepulse levels. At the 86 dBs prepulse level, rats tested during the light phase of the light/dark cycle displayed significantly lowered PPI as compared to the animals tested during the dark phase. Additionally, other measures such as baseline startle, habituation and activity during testing did not vary across the estrous or light cycles. These findings indicate that while estrous phase does not have any effect on PPI in female Sprague-Dawley rats when tested under these parameters, the time of day during which testing occurs does have the potential to alter PPI.

Selective Attention to Emotional Pictures as a Function of Gambling Motives in Problem and Nonproblem Gamblers

Problem gambling may reflect a maladaptive means of fulfilling specific affect-regulation motives, such as enhancing positive affect or coping with negative affect. Research with clinical populations indicates that disorders with prominent affective symptoms are characterized by attentional biases for symptom-congruent information. Thus, we assessed whether problem gamblers with enhancement motives for gambling would demonstrate attentional biases for positive emotional information, relative to other types of emotional information, and problem gamblers with coping motives for gambling would demonstrate attentional biases for negative emotional information, compared with other types of emotional information. In addition, we expected motive-congruent biases to be stronger in problem gamblers than nonproblem gamblers. To test these hypotheses, problem and nonproblem gamblers received an emotional orienting task in which neutral, negative, and positive pictorial cues appeared to one side of the computer screen, followed by target words in cued or uncued locations. In a look-away condition, participants had to shift attention away from pictures to respond to predominantly uncued targets, whereas in a look-toward condition, they had to orient to pictures to categorize predominantly cued targets. The results revealed motive-congruent orienting biases and disengagement lags for emotional pictures in problem gamblers. The link between motives and affective biases was less apparent in nonproblem gamblers. Results suggest that attentional measures may provide a useful complement to the subjective methodologies that are typically employed in studying problem gamblers.

Drinking motives and attentional bias to affective stimuli in problem and non-problem drinkers.

Problem drinking may reflect a maladaptive means of coping with negative emotions or enhancing positive emotions. Disorders with affective symptoms are often characterized by attentional biases for symptom-congruent emotionally valenced stimuli. Regarding addictions, coping motivated (CM) problem gamblers exhibit an attentional bias for negative stimuli, whereas enhancement motivated (EM) problem gamblers exhibit this bias for positive stimuli (Hudson, Jacques, & Stewart, 2013). We predicted that problem drinkers would show similar motive-congruent attentional biases. Problem and non-problem drinkers (n = 48 per group) completed an emotional orienting task measuring attentional biases to positive, negative, and neutral stimuli. As predicted, EM problem drinkers showed an attentional bias for positive information (i.e., reduced accuracy for positively cued trials). However, CM problem drinkers displayed a general distractibility (i.e., reduced accuracy, regardless of cue valence). The results add further support for Cooper et al.s (1992) motivational model of alcohol use, and indicate potential motivation-matched intervention targets. (PsycINFO Database Record

University Students’ Perceptions of Links Between Substance Use and Mental Health: A Qualitative Focus Group Study

There is a consensus among addictions researchers and clinicians that mental health concerns and substance use problems are often interrelated. It is less clear to what extent the general public, and university students in particular, understand connections between substance use and mental health. The current study aimed to understand university students’ perceived links between substance use and mental health by conducting three semistructured focus groups (N = 24 participants, 67% female). Thematic analysis of the data yielded five themes: (1) Students use substances to cope with mental health issues, (2) substance use can lead to mental health problems, (3) links between mental health and substance use are cyclical, (4) substance use is an aspect/indicator of mental health, and (5) substance use and mental health are not always linked. Findings provide insight into the understudied area of perceived links between substance use and mental health and have implications for campus programming.

Changes in coping and social motives for drinking and alcohol consumption across the menstrual cycle

Alcohol use has been reported to fluctuate over womens menstrual cycles (MCs), with increased intake occurring premenstrually/menstrually (phases characterized by heightened negative affect) and during the ovulatory phase (a phase characterized by positive affect). This suggests women may drink for particular emotion‐focused reasons at specific points in their cycles. However, no research had yet examined MC variability in drinking motives, or links between cycle‐related changes in drinking motives and alcohol consumption.

Examining the effects of gambling-relevant cues on gambling outcome expectancies

Abstract There is a consensus in the addictions literature that exposure to addiction-relevant cues can precipitate a desire to engage, or actual engagement, in the addictive behaviour. Previous work has shown that exposure to gambling-relevant cues activates gamblers’ positive gambling outcome expectancies (i.e. their beliefs about the positive results of gambling). The current study examined the effects of a new, arguably more ecologically valid cue manipulation (i.e. exposure to a gambling lab environment vs. sterile lab environment) on 61 regular gamblers’ explicit and implicit gambling outcome expectancies. The authors first tested the internal consistency of their implicit reaction time measure of gambling outcome expectancies, the Affective Priming Task. Split-half reliabilities were satisfactory to high (.72 to .88), highlighting an advantage of this task over other characteristically unreliable implicit cognitive measures. Unexpectedly, no predicted between-lab condition differences emerged on most measures of interest, suggesting that peripheral environmental cues that are not the focus of deliberate attentional allocation may not activate positive outcome expectancies. However, there was some evidence that implicit negative gambling outcome expectancies were activated in the gambling lab environment. This latter finding holds clinical relevance as it suggests that presenting peripheral gambling-related cues while treating problem gamblers may facilitate processing of the negative consequences of gambling.