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Dive into the research topics where Amanda N. Wilton is active.

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Featured researches published by Amanda N. Wilton.


Nucleosides, Nucleotides & Nucleic Acids | 1998

Strong, Specific, Reversible Binding Ligands for Transfer Rna: Comparison By Fluorescence and Nmr Spectroscopies with Distamycin Binding for a New Structural Class of Ligand

Elena V. Bichenkova; S Sadat-Ebrahimi; Amanda N. Wilton; Niamh OToole; Debora S. Marks; Kenneth T. Douglas

Abstract Binding data are presented for the interaction with brewers yeast tRNAPhc of a new structural family of ligands, symmetrical bis-benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNAPhc when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.


Chemical Communications | 1997

Unique binding site for bis-benzimidazoles on transfer RNA

Seyed Esmaeil Sadat Ebrahimi; Amanda N. Wilton; Kenneth T. Douglas

Ligands based on bis-benzimidazole structures related to Hoechst 33258 bind to transfer RNA with 1:1 stoichiometry and dissociation constants in the micromolar range, their interaction appearing significantly different in nature from that with duplex DNA, based on the ribonucleic acid-induced quenching of their fluorescence.


Organic and Biomolecular Chemistry | 2006

Exciplex fluorescence emission from simple organic intramolecular constructs in non-polar and highly polar media as model systems for DNA-assembled exciplex detectors

Elena V. Bichenkova; Ali Sardarian; Amanda N. Wilton; Pascal Bonnet; Richard A. Bryce; Kenneth T. Douglas


Biochemistry | 2001

Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: enzyme inhibitors which act by binding to substrate.

Yoshiaki Hori; Elena V. Bichenkova; Amanda N. Wilton; Mohamed N. El-Attug; S Sadat-Ebrahimi; Terumichi Tanaka; Yo Kikuchi; Michihiro Araki; Yukio Sugiura; Kenneth T. Douglas


Biochimica et Biophysica Acta | 2005

Porphyrins and porphines bind strongly and specifically to tRNA, precursor tRNA and to M1 RNA and inhibit the ribonuclease P ribozyme reaction.

Yoshiaki Hori; Maria Candelaria Rogert; Terumichi Tanaka; Yo Kikuchi; Elena V. Bichenkova; Amanda N. Wilton; Abdul Gbaj; Kenneth T. Douglas


Biochemistry | 1995

Predictability of designing specific binding interactions for DNA minor groove ligands from NMR spectroscopy and molecular modeling: a copper(II)-activated DNA cleaver based on Hoechst 33258.

John A. Parkinson; S Sadat-Ebrahimi; Amanda N. Wilton; James H. McKie; Julie Andrews; Kenneth T. Douglas


In: 29th Symposium on Nucleic Acids Chemistry, Kyoto, Japan, 20-22 November, Nucleic Acids Research Supplement No. 2; 2002. p. 111-112. | 2002

Porphyrins and porphines inhibit the ribonuclease P reaction in vitro.

Yoshiaki Hori; Ev Bichenkova; Amanda N. Wilton; Terumichi Tanaka; Kenneth T. Douglas; Yo Kikuchi


In: Biochemical Society Focused Meeting/EMBO Workshop, Ribozymes and RNA Catalysis, West Park Centre, Dundee, UK, 23-27 August; 2002. | 2002

Inhibitors of ribonuclease P reaction

Yoshiaki Hori; Ev Bichenkova; S Sadat-Ebrahimi; Amanda N. Wilton; Mohamed N. El-Attug; Terumichi Tanaka; Kenneth T. Douglas; Yo Kikuchi


Archive | 2001

Processing of pre-transfer RNA by ribonuclease P: design of synthetic inhibitors of a ribozyme

Yoshiaki Hori; Ev Bichenkova; Amanda N. Wilton; Mohamed N. El-Attug; S. Sadat-Ebrahimm; Terumichi Tanaka; Yo Kikuchi; Michihiro Araki; Yukio Sugiura; Kenneth T. Douglas


Archive | 2001

The first synthetic chemical inhibitors of the ribonuclease P ribozyme

Yoshiaki Hori; Ev Bichenkova; Amanda N. Wilton; Mn Attug; S Sadat-Ebrahimi; Terumichi Tanaka; Yo Kikuchi; Michihiro Araki; Yukio Sugiura; Kenneth T. Douglas

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Terumichi Tanaka

Toyohashi University of Technology

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Yo Kikuchi

Toyohashi University of Technology

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Yoshiaki Hori

Toyohashi University of Technology

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Ev Bichenkova

Toyohashi University of Technology

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