S Sadat-Ebrahimi | Researchain

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Featured researches published by S Sadat-Ebrahimi.

Nucleosides, Nucleotides & Nucleic Acids | 1998

Strong, Specific, Reversible Binding Ligands for Transfer Rna: Comparison By Fluorescence and Nmr Spectroscopies with Distamycin Binding for a New Structural Class of Ligand

Elena V. Bichenkova; S Sadat-Ebrahimi; Amanda N. Wilton; Niamh OToole; Debora S. Marks; Kenneth T. Douglas

Abstract Binding data are presented for the interaction with brewers yeast tRNAPhc of a new structural family of ligands, symmetrical bis-benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNAPhc when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.

Journal of Molecular Biology | 2001

Increased stability and lifetime of the complex formed between DNA and meta-phenyl-substituted Hoechst dyes as studied by fluorescence titrations and stopped-flow kinetics.

Sy Breusegem; S Sadat-Ebrahimi; Kenneth T. Douglas; Robert M. Clegg; Frank G. Loontiens

Biochemistry | 2001

Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: enzyme inhibitors which act by binding to substrate.

Yoshiaki Hori; Elena V. Bichenkova; Amanda N. Wilton; Mohamed N. El-Attug; S Sadat-Ebrahimi; Terumichi Tanaka; Yo Kikuchi; Michihiro Araki; Yukio Sugiura; Kenneth T. Douglas

Journal of Medicinal Chemistry | 2001

Experimental precedent for the need to involve the primary hydration layer of DNA in lead drug design.

Sy Breusegem; S Sadat-Ebrahimi; Kenneth T. Douglas; Elena V. Bichenkova; Robert M. Clegg; Frank G. Loontiens

Biochemistry | 1995

Predictability of designing specific binding interactions for DNA minor groove ligands from NMR spectroscopy and molecular modeling: a copper(II)-activated DNA cleaver based on Hoechst 33258.

John A. Parkinson; S Sadat-Ebrahimi; Amanda N. Wilton; James H. McKie; Julie Andrews; Kenneth T. Douglas

In: J. Biomol. Struct. Dynamics; 1997. p. 923-924. | 1997

Analogues of Hoechst 33258 bind to Transfer RNA with 1:1 Stoichiometry

An Wilton; Kt. Douglas; S Sadat-Ebrahimi

In: Biochemical Society Focused Meeting/EMBO Workshop, Ribozymes and RNA Catalysis, West Park Centre, Dundee, UK, 23-27 August; 2002. | 2002

Inhibitors of ribonuclease P reaction

Yoshiaki Hori; Ev Bichenkova; S Sadat-Ebrahimi; Amanda N. Wilton; Mohamed N. El-Attug; Terumichi Tanaka; Kenneth T. Douglas; Yo Kikuchi

Archive | 2001

The first synthetic chemical inhibitors of the ribonuclease P ribozyme

Yoshiaki Hori; Ev Bichenkova; Amanda N. Wilton; Mn Attug; S Sadat-Ebrahimi; Terumichi Tanaka; Yo Kikuchi; Michihiro Araki; Yukio Sugiura; Kenneth T. Douglas

Journal of Pharmacy and Pharmacology | 2000

The first synthetic inhibitor classes for ribonuclease P, the ribozyme maturing pre-transfer RNA

S Sadat-Ebrahimi; Yoshiaki Hori; Terumichi Tanaka; Yo Kikuchi; Amanda N. Wilton; Mohamed N. El-Attug; Michihiro Araki; Yukio Sugiura; Kenneth T. Douglas

In: B. Meunier (ed.), DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases. Kluwer Academic Publ; 1996. p. 177-193. | 1996