Amélia Spínola Santos

Body adiposity and bone parameters of male rats from mothers fed diet containing flaxseed flour during lactation

Obesity and osteoporosis may have their origins in early postnatal life. This study was designed to evaluate whether flaxseed flour use during lactation period bears effect on body adiposity and skeletal structure of male rat pups at weaning. At birth, male Wistar rats were randomly assigned to control and experimental (FF) groups, whose dams were treated with control or flaxseed flour diet, respectively, during lactation. At 21 days of age, pups were weaned to assess body mass, length and composition by dual-energy X-ray absorptiometry. The animals were then sacrificed to carry out analysis of serum profile, intra-abdominal adipocyte morphology and femur characteristics. Differences were considered significant when P<0.05. The FF group displayed the following characteristics (P<0.05): higher body mass, length, bone mineral content, bone area and concentrations of osteoprotegerin, osteocalcin and high-density lipoprotein cholesterol; higher levels of stearic, α-linolenic, eicosapentaenoic and docosapentaenoic acids and lower levels of arachidonic acid and cholesterol; smaller adipocyte area; and higher mass, epiphysis distance, diaphysis width, maximal load, break load, resilience and stiffness of femur. Flaxseed flour intake during lactation period promoted adipocyte hypertrophy down-regulation and contributed to pup bone quality at weaning.

O PAPEL DO OMALIZUMAB NA DERMATITE ATÓPICA GRAVE

Apresentam-se os casos de duas jovens, com diagnostico de dermatite atopica grave medicadas com anti-histaminicos orais, corticoides topicos, ciclos de corticoterapia sistemica em doses elevadas e/ou ciclosporina oral, sem melhoria e com agravamento clinico apos reducao da dose de corticoides sistemicos e/ou da ciclosporina. Na consulta de imunoalergologia efectuaram-se varios reajustes terapeuticos sem sucesso antes de iniciar terapeutica com omalizumab subcutâneo. Descreve-se a evolucao clinica destas 2 doentes sob terapeutica com omalizumab e discute-se o seu papel no tratamento da dermatite atopica.