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Dive into the research topics where Amrita Sethi is active.

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Featured researches published by Amrita Sethi.


Gastrointestinal Endoscopy | 2013

A multicenter, U.S. experience of single-balloon, double-balloon, and rotational overtube–assisted enteroscopy ERCP in patients with surgically altered pancreaticobiliary anatomy (with video)

Raj J. Shah; Maximiliano Smolkin; Roy D. Yen; Andrew S. Ross; Richard A. Kozarek; Douglas A. Howell; Gennadiy Bakis; Sreenivasan S. Jonnalagadda; Abed Al-Lehibi; Al Hardy; Douglas R. Morgan; Amrita Sethi; Peter D. Stevens; Paul Akerman; Shyam Thakkar; Brian C. Brauer

BACKGROUND Data on overtube-assisted enteroscopy to facilitate ERCP in patients with surgically altered pancreaticobiliary anatomy, or long-limb surgical bypass, is limited. OBJECTIVE To evaluate and compare ERCP success by using single-balloon (SBE), double-balloon (DBE), or rotational overtube enteroscopy. DESIGN Consecutive patients identified retrospectively. SETTING Eight U.S. referral centers. PATIENTS Long-limb surgical bypass patients with suspected pancreaticobiliary diseases. INTERVENTION Overtube-assisted enteroscopy ERCP. MAIN OUTCOME MEASUREMENTS Enteroscopy success: visualizing the pancreaticobiliary-enteric anastomosis or papilla. ERCP success: completing the intended pancreaticobiliary intervention. Clinical success: greater than 50% reduction in abdominal pain or level of hepatic enzyme elevations or resolution of jaundice. RESULTS From January 2008 through October 2009, 129 patients had 180 enteroscopy-ERCPs. Anatomy was Roux-en-Y: gastric bypass (n = 63), hepaticojejunostomy (n = 45), postgastrectomy (n = 6), Whipple procedure (n = 10), and other (n = 5). ERCP success was 81 of 129 (63%). Enteroscopy success: 92 of 129 (71%), of whom 81 of 92 (88%) achieved ERCP success. Reasons for ERCP failure (n = 48): afferent limb entered but pancreaticobiliary anastomosis and/or papilla not reached (n = 23), cannulation failure (n = 11), afferent limb angulation (n = 8), and jejunojejunostomy not identified (n = 6). Select interventions: anastomotic stricturoplasty (cautery ± dilation, n = 16), stone removal (n = 21), stent (n = 25), and direct cholangioscopy (n = 11). ERCP success rates were similar between Roux-en-Y gastric bypass and other long-limb surgical bypass and among SBE, DBE, and rotational overtube enteroscopy. Complications were 16 of 129, 12.4%. LIMITATIONS Retrospective study. CONCLUSION (1) ERCP is successful in nearly two-thirds of long-limb surgical bypass patients and in 88% when the papilla or pancreaticobiliary-enteric anastomosis is reached. (2) Enteroscopy success in long-limb surgical bypass is similar among SBE, DBE, and rotational overtube enteroscopy methods. (3) Referral of long-limb surgical bypass patients who require ERCP to high-volume institutions may be considered before more invasive percutaneous or surgical alternatives.


Gastrointestinal Endoscopy | 2011

ERCP with cholangiopancreatoscopy may be associated with higher rates of complications than ERCP alone: a single-center experience

Amrita Sethi; Yang K. Chen; Gregory L. Austin; William R. Brown; Brian C. Brauer; Norio Fukami; Abdul H. Khan; Raj J. Shah

BACKGROUND Comparative data regarding complications associated with ERCP alone or when performed with cholangiopancreatoscopy (CP) are lacking. OBJECTIVE To determine whether ERCP complications are more frequent when concomitant CP is performed. DESIGN A retrospective query of a prospectively maintained database of ERCP, CP, and complications. MAIN OUTCOME MEASUREMENTS Consensus criteria complications and additional adverse events (AEs), including unplanned medical evaluation, cardiopulmonary/sedation events, and others. SETTING Academic, tertiary referral center. RESULTS A total of 4214 ERCPs were performed (337 sphincter of Oddi manometry cases excluded) during the study period, of which 3475 ERCPs and 402 ERCPs with CP were analyzed. There were 28 of 402 AEs (7.0%) in the ERCP with CP group and 101 of 3475 (2.9%) in the ERCP-only group (odds ratio [OR], 2.50; 95% CI, 1.56-3.89). Subgroup analysis revealed a significantly higher rate of cholangitis in the CP group versus ERCP group (1.0% vs 0.2%; OR, 4.98; 95% CI, 1.06-19.67) and similar rates of pancreatitis (2.2% vs 1.3%; OR, 1.75; 95% CI, 0.74-3.65) and perforation (1.0% vs 0.3%; OR, 3.16; 95% CI, 0.73-10.75). LIMITATIONS Retrospective review of a complications database that relies on physician self-reporting. CONCLUSIONS AEs from CP may be more than double those of ERCP alone (when sphincter of Oddi manometry cases are excluded). CP appears to be associated with a significantly higher rate of cholangitis, possibly because of intermittent intraductal irrigation required during the procedure.


Journal of Clinical Gastroenterology | 2013

Multicenter trial evaluating the use of covered self-expanding metal stents in benign biliary strictures: time to revisit our therapeutic options?

Michel Kahaleh; Alan Brijbassie; Amrita Sethi; Marisa Degaetani; John M. Poneros; David E. Loren; Thomas E. Kowalski; Divyesh V. Sejpal; Sandeep Patel; Laura Rosenkranz; Kevin N. Mcnamara; Isaac Raijman; Jayant P. Talreja; Monica Gaidhane; Bryan G. Sauer; Peter D. Stevens

Background: Covered self-expanding metal stents are being used more frequently in benign biliary strictures (BBS). We report the results of a multicenter study with fully covered self-expanding metal stent (FCSEMS) placement for the management of BBS. Aim: To prospectively evaluate the efficacy and safety of FCSEMS in the management of BBS. Patients and Methods: Patients with BBS from 6 tertiary care centers who received FCSEMS with flared ends between April 2009 and October 2010 were included in this retrospective study. Efficacy was measured after removal of FCSEMS by evaluating stricture resolution on the basis of symptom resolution, imaging, laboratory studies, and/or choledochoscopy at removal. Safety profile was evaluated by assessing postprocedural complications. Results: A total of 133 patients (78, 58.6% males) with a mean age of 59.2±14.8 years with BBS received stents. Of the 133 stents placed, 97 (72.9%) were removed after a mean stent duration of 95.5±48.7 days. Stricture resolution after FCSEMS removal was as follows: postsurgical, 11/12 (91.6%); gallstone-related disease, 16/19 (84.2%); chronic pancreatitis, 26/31 (80.7%); other etiology, 4/5 (80.0%); and anastomotic strictures, 19/31(61.2%). Ninety-four patients were included in the logistic regression analyses. Patients who had indwelling stents for >90 days were 4.3 times more likely to have resolved strictures [odds ratio, 4.3 (95% confidence interval, 1.24-15.09)] and patients with nonmigrated stents were 5.4 times more likely to have resolved strictures [odds ratio, 5.4 (95% confidence interval, 1.001-29.29)]. Conclusions: FCSEMS for BBS had an acceptable rate of stricture resolution for postsurgical strictures, gallstone-related strictures, and those due to chronic pancreatitis. Predictors for stricture resolution include longer indwell time and absence of migration. Further study is warranted to assess long-term efficacy in a prospective manner with longer than 3-month time of stent indwelling time.


Journal of Clinical Gastroenterology | 2014

Pancreatic Necrosectomy Using Covered Esophageal Stents A Novel Approach

Savreet Sarkaria; Amrita Sethi; Carlos Rondon; Michael W. Lieberman; Indu Srinivasan; Kristen Weaver; Brian G. Turner; Subha V. Sundararajan; David Berlin; Monica Gaidhane; Daniil Rolshud; Jessica L. Widmer; Michel Kahaleh

Background: Endoscopic necrosectomy for necrotizing pancreatitis has been increasingly used as an alternative to surgical or percutaneous interventions. The use of fully covered esophageal self-expandable metallic stents may provide a safer and more efficient route for internal drainage. The aim of this study was to evaluate the safety and efficacy of endoscopic treatment of pancreatic necrosis with these stents. Methods: A retrospective study at 2 US academic hospitals included patients with infected pancreatic necrosis from July 2009 to November 2012. These patients underwent transgastric placement of fully covered esophageal metallic stents draining the necrosis. After necrosectomy, patients underwent regular sessions of endoscopic irrigation and debridement of cystic contents. The efficacy endpoint was successful resolution of infected pancreatic necrosis without the need for surgical or percutaneous interventions. Results: Seventeen patients were included with the mean age of 41±12 years. A mean of 5.3±3.4 sessions were required for complete drainage and the follow-up period was 237.6±165 days. Etiology included gallstone pancreatitis (6), alcohol abuse (6), s/p distal pancreatectomy (2), postendoscopic retrograde cholangiopancreatography pancreatitis (1), medication-induced pancreatitis (1), and hyperlipidemia (1). Mean size of the necrosis was 14.8 cm (SD 5.6 cm), ranging from 8 to 19 cm. Two patients failed endoscopic intervention and required surgery. The only complication was a perforation during tract dilation, which was managed conservatively. Fifteen patients (88%) achieved complete resolution. Conclusions: Endoscopic necrosectomy with covered esophageal metal stents is a safe and successful treatment option for infected pancreatic necrosis.


Journal of Clinical Gastroenterology | 2015

A Large Multicenter Experience With Endoscopic Suturing for Management of Gastrointestinal Defects and Stent Anchorage in 122 Patients: A Retrospective Review.

Reem Z. Sharaiha; Nikhil A. Kumta; Ersilia M. DeFilippis; Christopher J. DiMaio; Susana Gonzalez; Tamas A. Gonda; Jason N. Rogart; Ali Siddiqui; Paul S. Berg; Paul Samuels; Lawrence A. Miller; Mouen A. Khashab; Payal Saxena; Monica Gaidhane; Amy Tyberg; Julio Teixeira; Jessica L. Widmer; Prashant Kedia; David E. Loren; Michel Kahaleh; Amrita Sethi

Goals:To describe a multicenter experience using an endoscopic suturing device for management of gastrointestinal (GI) defects and stent anchorage. Background:Endoscopic closure of GI defects including perforations, fistulas, and anastomotic leaks as well as stent anchorage has improved with technological advances. An endoscopic suturing device (OverStitch; Apollo Endosurgery Inc.) has been used. Study:Retrospective study of consecutive patients who underwent endoscopic suturing for management of GI defects and/or stent anchorage were enrolled between March 2012 and January 2014 at multiple academic medical centers. Data regarding demographic information and outcomes including long-term success were collected. Results:One hundred and twenty-two patients (mean age, 52.6 y; 64.2% females) underwent endoscopic suturing at 8 centers for stent anchorage (n=47; 38.5%), fistulas (n=40; 32.7%), leaks (n=15; 12.3%), and perforations (n=20; 16.4%). A total of 44.2% underwent prior therapy and 97.5% achieved technical success. Immediate clinical success was achieved in 79.5%. Long-term clinical success was noted in 78.8% with mean follow-up of 68 days. Clinical success was 91.4% in stent anchorage, 93% in perforations, 80% in fistulas, but only 27% in anastomotic leak closure. Conclusions:Endoscopic suturing for management of GI defects and stent anchoring is safe and efficacious. Stent migration after stent anchoring was reduced compared with published data. Long-term success without further intervention was achieved in the majority of patients. The role of endoscopic suturing for repair of anastomotic leaks remains unclear given limited success in this retrospective study.


Endoscopy International Open | 2016

Initial experience with a novel EUS-guided core biopsy needle (SharkCore): results of a large North American multicenter study.

Christopher J. DiMaio; Jennifer M. Kolb; Petros C. Benias; Hiral N Shah Md; Shashin Shah Md; Oleh Haluszka; Jennifer L. Maranki; Kaveh Sharzehi; Eric Lam; Stuart R. Gordon; Sarah M. Hyder; Pavlos Z. Kaimakliotis; Satya Allaparthi; Frank G. Gress; Amrita Sethi; Ashish R. Shah; Jose Nieto; Vivek Kaul; Shivangi Kothari; Truptesh H. Kothari; Sammy Ho; Manhal Izzy; Neil Sharma; Rabindra R. Watson; V. Raman Muthusamy; Douglas K. Pleskow; Tyler M. Berzin; Mandeep Sawhney; Emad Aljahdi; Marvin Ryou

Background and aims: The ability to safely and effectively obtain sufficient tissue for pathologic evaluation by using endoscopic ultrasound (EUS) guidance remains a challenge. Novel designs in EUS needles may provide for improved ability to obtain such core biopsies. The aim of this study was to evaluate the diagnostic yield of core biopsy specimens obtained using a novel EUS needle specifically designed to obtain core biopsies. Patients and methods: Multicenter retrospective review of all EUS-guided fine-needle biopsies obtained using a novel biopsy needle (SharkCore FNB needle, Medtronic, Dublin, Ireland). Data regarding patient demographics, lesion type/location, technical parameters, and diagnostic yield was obtained. Results: A total of 250 lesions were biopsied in 226 patients (Median age 66 years; 113 (50 %) male). Median size of all lesions (mm): 26 (2 – 150). Overall, a cytologic diagnosis was rendered in 81 % specimens with a median number of 3 passes. When rapid onsite cytologic evaluation (ROSE) was used, cytologic diagnostic yield was 126/149 (85 %) with a median number of 3 passes; without ROSE, cytologic diagnostic yield was 31/45 (69 %, P = 0.03) with a median number of 3 passes. Overall, a pathologic diagnosis was rendered in 130/147 (88 %) specimens with a median number of 2 passes. Pathologic diagnostic yield for specific lesion types: pancreas 70/81 (86 %), subepithelial lesion 13/15 (87 %), lymph node 26/28 (93 %). Ten patients (10/226, 4 %) experienced adverse events: 4 acute pancreatitis, 5 pain, 1 fever/cholangitis. Conclusions: Initial experience with a novel EUS core biopsy needle demonstrates excellent pathologic diagnostic yield with a minimum number of passes.


Digestive and Liver Disease | 2014

Interobserver agreement for evaluation of imaging with single operator choledochoscopy: What are we looking at?

Amrita Sethi; Jessica L. Widmer; Neeral L. Shah; Douglas K. Pleskow; Steven A. Edmundowicz; Divyesh V. Sejpal; Frank G. Gress; George H. Pop; Monica Gaidhane; Bryan G. Sauer; Peter D. Stevens; Michel Kahaleh

BACKGROUND Single operator choledochoscopy is a platform used to assist in the confirmation of diagnosis of biliary lesions. However, there are little data regarding the interobserver agreement of imaging interpretation. Our objective was to assess the interobserver agreement in single operator choledochoscopy interpretation. METHODS 38 De-identified SPY Choledochoscopy video clips were sent to 7 interventional endoscopists. They were asked to score the videos on presence of four criteria selected by the investigators: growth, stricture, hyperplasia, and ulceration. Observers also chose a final diagnosis from the categories of cancer, hyperplasia, inflammation, or normal. Kappa scores were calculated for the scoring of the four criteria and for the selection of the final diagnosis. RESULTS The overall interobserver agreement was fair in scoring for the presence of a growth (K=0.28, SE 0.035) and stricture (K=0.32, SE 0.035). Scoring for ulceration was slight to fair (K=0.17, SE 0.035). There was only slight agreement for the presence of hyperplasia (K=0.11, SE 0.035); and presumed final diagnosis based on imaging (K=0.18, SE 0.022). CONCLUSION The results of this study support the need for an effort to identify and validate cholangioscopy imaging criteria for biliary pathology. This may assist in improving the reliability of the diagnostic value of cholangioscopy as its use becomes more widespread.


Cancer Cytopathology | 2014

Fine‐needle aspirations of pancreatic serous cystadenomas: Improving diagnostic yield with cell blocks and α‐inhibin immunohistochemistry

Marcela Salomao; Helen Remotti; John D. Allendorf; John M. Poneros; Amrita Sethi; Tamas A. Gonda; Anjali Saqi

The diagnosis of serous cystadenoma (SCA), a rare benign pancreatic neoplasm, can alter the management of patients with pancreatic masses. Although characteristic imaging findings and fluid chemical analysis have been described, SCAs are not always recognized preoperatively. Furthermore, scant cellular yield on fine‐needle aspiration (FNA) often leads to a nondiagnostic or nonspecific benign diagnosis. α‐Inhibin (AI), a sensitive marker for SCA, is infrequently required for diagnosis in surgical specimens due to their characteristic histologic appearance. The objective of the current study was to determine whether AI staining can improve SCA diagnosis on FNA specimens.


Gastrointestinal Endoscopy | 2011

Fully covered self-expandable metal stents for benign esophageal disease: a multicenter retrospective case series of 31 patients

Jonathan M. Buscaglia; Sammy Ho; Amrita Sethi; Christopher J. DiMaio; Satish Nagula; Stavros N. Stavropoulos; Tamas A. Gonda; John M. Poneros; Peter D. Stevens

failure to thrive, aspiration causing recurrent pneumonia, upper respiratory tract infection, and food or foreign-body impaction.7,8 Esophagography was the primary diagnostic tool and was performed in all patients (Fig. 5). The esophagography results showed segmental stenosis at the distal third of the esophagus in all patients except 1. Esophagoscopy was performed in most patients and usually showed a nonspecific distal esophageal stenosis without inflammation. Repeated dilation of the stricture was performed in 33 patients, resulting in only transient or no relief of dysphagia. Three patients had esophageal perforation after dilation, with 1 death after a single dilation. In most of the patients, definitive treatment was performed between 1 and 3 months of age, and surgical resection was required. The diagnosis of TBRs (57 patients) could only be made by histopathological examination of the resected segment, thus underscoring the importance of EUS in the preoperative diagnosis of TBRs.


Endoscopy | 2016

Endoscopic suturing for the prevention of stent migration in benign upper gastrointestinal conditions: a comparative multicenter study

Saowanee Ngamruengphong; Reem Z. Sharaiha; Amrita Sethi; Ali Siddiqui; Christopher J. DiMaio; Susana Gonzalez; Jennifer Im; Jason N. Rogart; Sophia Jagroop; Jessica L. Widmer; Raza Hasan; Sobia N. Laique; Tamas A. Gonda; John M. Poneros; Amit P. Desai; Amy Tyberg; Vivek Kumbhari; Mohamad H. El Zein; Ahmed Abdelgelil; Sepideh Besharati; Ruben Hernaez; Patrick I. Okolo; Vikesh K. Singh; Anthony N. Kalloo; Michel Kahaleh; Mouen A. Khashab

BACKGROUND AND STUDY AIMS Fully covered self-expandable metal stents (FCSEMSs) have increasingly been used in benign upper gastrointestinal (UGI) conditions; however, stent migration remains a major limitation. Endoscopic suture fixation (ESF) may prevent stent migration. The aims of this study were to compare the frequency of stent migration in patients who received endoscopic suturing for stent fixation (ESF group) compared with those who did not (NSF group) and to assess the impact of ESF on clinical outcome. PATIENTS AND METHODS This was a retrospective study of patients who underwent FCSEMS placement for benign UGI diseases. Patients were divided into either the NSF or ESF group. Outcome variables, including stent migration, clinical success (resolution of underlying pathology), and adverse events, were compared. RESULTS A total of 125 patients (44 in ESF group, 81 in NSF group; 56 benign strictures, 69 leaks/fistulas/perforations) underwent 224 stenting procedures. Stent migration was significantly more common in the NSF group (33 % vs. 16 %; P = 0.03). Time to stent migration was longer in the ESF group (P = 0.02). ESF appeared to protect against stent migration in patients with a history of stent migration (adjusted odds ratio [OR] 0.09; P = 0.002). ESF was also significantly associated with a higher rate of clinical success (60 % vs. 38 %; P = 0.03). Rates of adverse events were similar between the two groups. CONCLUSIONS Endoscopic suturing for stent fixation is safe and associated with a decreased migration rate, particularly in patients with a prior history of stent migration. It may also improve clinical response, likely because of the reduction in stent migration.

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Tamas A. Gonda

Columbia University Medical Center

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John M. Poneros

Columbia University Medical Center

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Frank G. Gress

Columbia University Medical Center

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Christopher J. DiMaio

Icahn School of Medicine at Mount Sinai

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Peter D. Stevens

Columbia University Medical Center

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Sammy Ho

Montefiore Medical Center

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