Anand Sachar

A new iridoid glycoside from Vitex negundo Linn (Verbenacea).

Five compounds have been isolated from the leaves of Vitex negundo Linn (Verbenacea) and their structures established by spectral analysis. Compound 1 has been identified and characterised as a new iridoid with a novel structure which has never before been reported in literature from Vitex or any other source. Its structure has been established as 1,4a,5,7a-tetrahydro-1-β-D-glucosyl-7-(3′,4′-dihydroxybenzoyloxymethyl)-5-ketocyclopenta[c]pyran-4-carboxylic acid. Other compounds, 2, 3, 4 and 5, have been identified as luteolin-7-O-β-D glucoside, nishindaside, negundoside, and agnuside, respectively. Compound 2, a flavone-O-glycoside, is being reported from this plant for the first time, and compounds 3, 4 and 5 are structurally known iridoids.

A novel approach towards the synthesis of tricyclic systems based on pyridine, pyran, thiopyran, azepine, oxepin, thiepin, and pyrimidine rings under different solvent conditions

Synthesis of some oxygen, nitrogen, and sulfur based condensed heterocycles by the condensation of dimedone with aromatic monoaldehyde under different solvent conditions has been achieved.