Ananya Madiyal

Central Hemangioma Involving the Mandible: A Rare Condition: Case Report and Review of Literature

Intraosseous hemangiomas are quite a rare condition and those occurring in the mandible often pose a diagnostic dilemma to the Dental surgeon as they present with variable and atypical radiographic manifestations. Biopsy or surgical excision of the lesion can result in severe haemorrhage, leading even to death; therefore accurate clinical and radiographic diagnosis is essential before any surgical intervention is started. In this paper, we discuss a case of central hemangioma of the mandible occurring in a 17-year-old male patient, angiography was used for diagnosis and was treated with surgical excision. Intraosseoz hemanjiomlar ender gorulen bir durumdur ve mandibulada gorulen hemanjiyomlar siklikla dishekimleri icin degisken ve atipik radyografik bulgularla ortaya ciktigi icin tani ikilemi olustururlar. Biyopsi ya da lezyonun cerrahi olarak eksizyonu ciddi kanamalara neden olabilir, olumle bile sonuclanabilir; bu nedenle herhangi bir cerrahi isleme baslamadan once dogru klinik ve radyolojik tani gereklidir. Bu yazida, 17 yasindaki erkek hastada mandibulanin santral hemanjiyom olgusu tartisilmistir. Anjiyografi tani icin kullanilmis ve cerrahi eksizyon ile tedavi edilmistir.

Goldenhar syndrome: Report of two cases with review of literature

Goldenhar syndrome consists of a varied group of malformations that can involve multiple systems of the body. It is believed to be a variant of hemifacial microsomia with ocular and vertebral involvement. Characteristic findings, such as hypoplasia of one half of the face, epibulbar dermoids, ear tags, and spinal cord defects, warrant the name occulo-auriculo-vertebral dysplasia. The syndrome occurs due to imbalance in cells during the blastogenesis period of embryo formation. It is found to involve the derivatives of first and second branchial arches. The condition is apparent at birth, but the phenotype can vary greatly in its severity depending on the activation and expression of the defective gene. Reported here are detailed clinical and radiographic features of two sporadic cases of Goldenhar syndrome in young males. This work mainly highlights the various theories of etiopathogenesis as well as step-wise management protocol for patients diagnosed with the syndrome.

Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers

Background Use of tobacco is often implicated in the development of oral diseases. Questionable accuracy of the traditional questionnaires to assess cigarette exposure necessitates the use of biomarkers like thiocyanate which provide a definitive quantitative measure. Objective To assess the rise in the level of thiocyanate for measurement of smoking behaviour in adults. Materials and methods Serum and salivary thiocyanate levels were estimated in 20 non-smokers, 20 ex-smokers and 40 smokers. Smokers were divided into two groups based on the presence or absence of oral mucosal lesions. Results The mean serum and salivary thiocyanate levels were increased significantly in smokers when compared to non-smokers and ex-smokers. The levels were not significantly different between ex-smokers and non-smokers and between smokers with tobacco related oral mucosal lesions and those without. Statistically significant correlation was seen between the serum and salivary levels of thiocyanate. Conclusion This study highlights the high level of thiocyanate in the serum and saliva of smokers when compared to non-smokers and ex-smokers. Significant increase in thiocyanate level was also seen in saliva. Hence it can be stated that saliva can be used as a reliable, non-invasive tool to assess smoking behaviour in the population and its changes over time.

Bir fibro-kemik lezyonunu taklit eden desmoplastik ameloblastoma

Desmoplastik ameloblastoma farkli klinik, radyografik ve histopatolojik ozellikler gosterir. Kapsamli stroma kolonizasyonu veya desmoplaziyi iceren olagandisi histomorfoloji ile karakterizedir. Tumorun karisik radyoopak-radyolusent gorunumu, taniyi karmasik hale getirir ve tedavi modalitesinde tedavide gecikmeye veya aggresivite eksikligine neden olur. Bu maksillerde ortaya cikma egilimi ve infiltratif dogasi ile birlikte desmoplastik ameloblastoma yanlis teshis icin tehlikeli bir lezyon olusturur. Burada fibro-osseoz lezyonun klinik ve radyografik ozelliklerini gosteren, bu nedenle histopatolojik dogrulama gerektiren bir desmoplastik ameloblastom olgusunu sunuyoruz. Hint alt kitasinda bildirilen vakalarin azligi ile bu alisilmadik lezyonla ilgili bilgi birikimimizi iyilestirmeyi ve erken ve dogru teshisinin onemini ortaya koymayi umuyoruz.

Dentinogenezis imperfecta tip 2 ile ilgili sıradışı özellikler: ailesi üç kuşaktan fazla etkilenmiş iki olgu

Dentinogenesis imperfecta (DI) otozomal dominat genetik bir hastaliktir. Yuksek derecede penetrasyon ve dusuk mutasyon oranina sahiptir. DI opalesant dentin ve dislerde renk degisikligi ile karakterizedir. Dentin siddetli yipranmaya maruz kalabilir. Bu durumun erken tani ve tedavisi, diger komplikasyonlarin onlenmesinde ve estetik amac icin gereklidir. Bu calismada uc kusak boyunca DI tip 2 den etkilenmis bir aileden iki vakanin klinik ve radyolojik ozellikleri sunulmustur. Bu rapor ayni zamanda 16 yasindaki bir erkekte DI ozellikleri ile birlikte odontom ve coklu disler gibi nadir gorulenozellikleri vurgulamaktadir.

Siblings with pierre robin sequence

Pierre Robin anomalad is a syndrome characterized by cleft of the palate, micrognathia of the mandible, and glossoptosis. This syndrome can occur as an individual presentation, or it may be associated with a wide variety of syndromes and anomalies. Such patients are burdened with several problems, some obvious and some less so. The most obvious problems such as the psychological difficulties the patients will have to face due to the appearance and associated problems such as feeding and speech difficulties and serious consequences such as airway obstruction. Here, we report two cases of Pierre Robin sequence seen in the same family in two children of the same parents.

Basal cell adenocarcinoma of the tongue- A rarity Case report

Abstract Basal cell adenocarcinoma is an unusual basaloid tumour that usually affects the parotid and very rarely involves the submandibular or minor salivary glands. It constitutes 1.6% of all salivary gland tumours and occurs as an asymptomatic freely mobile mass with occasional lymph node metastasis. Differentiation from benign salivary gland tumours like basal cell adenoma is accomplished by determining the depth of tumour invasion and patterns of growth or infiltration. Although it is categorised as a low-grade malignancy, it has a high propensity for recurrence. Surgical excision with a wide margin is the preferred course of treatment with radiotherapy being reserved only for tumours of the minor salivary glands with a diffuse pattern of infiltration. We present here a case of basal cell adenocarcinoma with a rare presentation in the minor salivary glands of the tongue which arose from a previously treated basal cell adenoma in the same site.

Serum and salivary myeloperoxidase in oral squamous cell carcinoma: A preliminary study

Background: Free radical damage to biologic molecules forms a basis for cancer development. Since DNA damage and methylation states are influenced by oxidative species catalyzed by myeloperoxidase (MPO), this enzyme is postulated to have a role in the occurrence of cancer. MPO has been studied in cancers such as those of the lung, ovary, and breast. However, serum and salivary studies of MPO in oral cancer are lacking. Aims: (1) To determine the MPO levels in the serum and saliva of patients with primary oral squamous cell carcinoma (OSCC). (2) To compare and correlate the serum and salivary MPO levels in patients with primary OSCC and healthy controls. Subjects and Methods: A total of 30 subjects were involved in this study, of which study group consisted of 15 subjects and control group consisted of 15 subjects. Study group included subjects with histologically proven primary OSCC. Serum and salivary samples were collected from all the subjects. Results: The results showed that the serum levels of MPO were slightly higher in the study group as compared to the control group; however, the difference was not significant. In saliva, levels of MPO were slightly lower in the study group as compared to the control group. The difference was not significant. Conclusions: This study could not find a significant correlation between serum and salivary MPO and OSCC. However, our study consisted of a limited number of samples and as such can be considered a pilot study. Studies with larger sample size are needed to give better insight into the role of MPO in OSCC.