Anca Radulescu
University of Colorado Boulder
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Featured researches published by Anca Radulescu.
PLOS ONE | 2013
Anca Radulescu; Lilianne R. Mujica-Parodi
It has previously been established that, in threatening situations, animals use alarm pheromones to communicate danger. There is emerging evidence of analogous chemosensory “stress” cues in humans. For this study, we collected alarm and exercise sweat from “donors,” extracted it, pooled it and presented it to 16 unrelated “detector” subjects undergoing fMRI. The fMRI protocol consisted of four stimulus runs, with each combination of stimulus condition and donor gender represented four times. Because olfactory stimuli do not follow the canonical hemodynamic response, we used a model-free approach. We performed minimal preprocessing and worked directly with block-average time series and step-function estimates. We found that, while male stress sweat produced a comparably strong emotional response in both detector genders, female stress sweat produced a markedly stronger arousal in female than in male detectors. Our statistical tests pinpointed this gender-specificity to the right amygdala (strongest in the superficial nuclei). When comparing the olfactory bulb responses to the corresponding stimuli, we found no significant differences between male and female detectors. These imaging results complement existing behavioral evidence, by identifying whether gender differences in response to alarm chemosignals are initiated at the perceptual versus emotional level. Since we found no significant differences in the olfactory bulb (primary processing site for chemosensory signals in mammals), we infer that the specificity in responding to female fear is likely based on processing meaning, rather than strength, of chemosensory cues from each gender.
Human Brain Mapping | 2012
Anca Radulescu; Denis Rubin; Helmut H. Strey; Lilianne R. Mujica-Parodi
Theory and experimental evidence suggest that complex living systems function close to the boundary of chaos, with erroneous organization to an improper dynamical range (too stiff or chaotic) underlying system‐wide dysregulation and disease. We hypothesized that erroneous organization might therefore also characterize paranoid schizophrenia, via optimization abnormalities in the prefrontal‐limbic circuit regulating emotion. To test this, we acquired fMRI scans from 35 subjects (N = 9 patients with paranoid schizophrenia and N = 26 healthy controls), while they viewed affect‐valent stimuli. To quantify dynamic regulation, we analyzed the power spectrum scale invariance (PSSI) of fMRI time‐courses and computed the geometry of time‐delay (Poincaré) maps, a measure of variability. Patients and controls showed distinct PSSI in two clusters (k1: Z = 4.3215, P = 0.00002 and k2: Z = 3.9441, P = 0.00008), localized to the orbitofrontal/medial prefrontal cortex (Brodmann Area 10), represented by β close to white noise in patients (β ≈ 0) and in the pink noise range in controls (β ≈ −1). Interpreting the meaning of PSSI differences, the Poincaré maps indicated less variability in patients than controls (Z = −1.9437, P = 0.05 for k1; Z = −2.5099, P = 0.01 for k2). That the dynamics identified Brodmann Area 10 is consistent with previous schizophrenia research, which implicates this area in deficits of working memory, executive functioning, emotional regulation and underlying biological abnormalities in synaptic (glutamatergic) transmission. Our results additionally cohere with a large body of work finding pink noise to be the normal range of central function at the synaptic, cellular, and small network levels, and suggest that patients show less supple responsivity of this region. Hum Brain Mapp, 2011.
Journal of Theoretical Biology | 2009
Anca Radulescu; Kingsley J. A. Cox; Paul R. Adams
BACKGROUND Recent work on long term potentiation in brain slices shows that Hebbs rule is not completely synapse-specific, probably due to intersynapse diffusion of calcium or other factors. We previously suggested that such errors in Hebbian learning might be analogous to mutations in evolution. METHODS AND FINDINGS We examine this proposal quantitatively, extending the classical Oja unsupervised model of learning by a single linear neuron to include Hebbian inspecificity. We introduce an error matrix E, which expresses possible crosstalk between updating at different connections. When there is no inspecificity, this gives the classical result of convergence to the first principal component of the input distribution (PC1). We show the modified algorithm converges to the leading eigenvector of the matrix EC, where C is the input covariance matrix. In the most biologically plausible case when there are no intrinsically privileged connections, E has diagonal elements Q and off-diagonal elements (1-Q)/(n-1), where Q, the quality, is expected to decrease with the number of inputs n and with a synaptic parameter b that reflects synapse density, calcium diffusion, etc. We study the dependence of the learning accuracy on b, n and the amount of input activity or correlation (analytically and computationally). We find that accuracy increases (learning becomes gradually less useful) with increases in b, particularly for intermediate (i.e., biologically realistic) correlation strength, although some useful learning always occurs up to the trivial limit Q=1/n. CONCLUSIONS AND SIGNIFICANCE We discuss the relation of our results to Hebbian unsupervised learning in the brain. When the mechanism lacks specificity, the network fails to learn the expected, and typically most useful, result, especially when the input correlation is weak. Hebbian crosstalk would reflect the very high density of synapses along dendrites, and inevitably degrades learning.
PLOS ONE | 2010
Anca Radulescu
Several firing patterns experimentally observed in neural populations have been successfully correlated to animal behavior. Population bursting, hereby regarded as a period of high firing rate followed by a period of quiescence, is typically observed in groups of neurons during behavior. Biophysical membrane-potential models of single cell bursting involve at least three equations. Extending such models to study the collective behavior of neural populations involves thousands of equations and can be very expensive computationally. For this reason, low dimensional population models that capture biophysical aspects of networks are needed. The present paper uses a firing-rate model to study mechanisms that trigger and stop transitions between tonic and phasic population firing. These mechanisms are captured through a two-dimensional system, which can potentially be extended to include interactions between different areas of the nervous system with a small number of equations. The typical behavior of midbrain dopaminergic neurons in the rodent is used as an example to illustrate and interpret our results. The model presented here can be used as a building block to study interactions between networks of neurons. This theoretical approach may help contextualize and understand the factors involved in regulating burst firing in populations and how it may modulate distinct aspects of behavior.
Journal of Theoretical Biology | 2008
Anca Radulescu
Discrete and Continuous Dynamical Systems | 2007
Anca Radulescu
Journal of Statistical Physics | 2007
Anca Radulescu
arXiv: Neurons and Cognition | 2013
Anca Radulescu
arXiv: Neurons and Cognition | 2008
Anca Radulescu; Kingsley J. A. Cox; Paul R. Adams
Schizophrenia Research | 2010
Anca Radulescu; Denis Rubin; Lilianne R. Mujica-Parodi