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Andrea Gailunas

Upjohn

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Publication

Featured researches published by Andrea Gailunas.

Bioorganic & Medicinal Chemistry Letters | 2010

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

Gary D. Probst; Simeon Bowers; Jennifer Sealy; Brian P. Stupi; Darren B. Dressen; Barbara Jagodzinska; Jose Aquino; Andrea Gailunas; Anh P. Truong; Luke Tso; Ying-Zi Xu; Roy K. Hom; Varghese John; Jay S. Tung; Michael A. Pleiss; John A. Tucker; Andrei W. Konradi; Hing L. Sham; Jacek Jagodzinski; Gergely Toth; Eric Brecht; Nanhua Yao; Hu Pan; May Lin; Dean R. Artis; Lany Ruslim; Michael P. Bova; Sukanto Sinha; Ted Yednock; Shawn Gauby

The structure-activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-gp liability compared to benzyl amine analog 1.

Archive | 2002

N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives

Varghese John; Michel Maillard; Barbara Jagodzinska; James P. Beck; Andrea Gailunas; John Freskos; John Mickelson; Lakshman Samala; Jennifer Sealy; Ruth E. Tenbrink; Lawrence Fang

Archive | 2001

Compounds to treat alzheimer's disease

Roy K. Hom; Shumeye S. Mamo; Jay Tung; Andrea Gailunas; Varghese John; Lawrence Y. Fang

Journal of Medicinal Chemistry | 2004

Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human β-secretase

Roy K. Hom; Andrea Gailunas; Shumeye S. Mamo; Larry Fang; Jay S. Tung; Donald E. Walker; David P. Davis; Eugene D. Thorsett; Nancy Jewett; Joseph B. Moon; Varghese John

Journal of Medicinal Chemistry | 2003

Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

Roy K. Hom; Larry Fang; Shumeye S. Mamo; Jay S. Tung; Ashley C. Guinn; Don Walker; David L. Davis; Andrea Gailunas; Eugene D. Thorsett; Sukanto Sinha; Jeroen Knops; Nancy Jewett; John P. Anderson; Varghese John

Archive | 2002

N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds

Andrea Gailunas; John A. Tucker; Ruth E. Tenbrink; John Mickelson

Archive | 2001

Compounds and methods to treat alzheimer's disease

Roy K. Hom; Shumeye S. Mamo; Jay Tung; Andrea Gailunas; Varghese John; Larry Fang

Archive | 2002

Substituted amines for the treatment of alzheimer's disease

Andrea Gailunas; John A. Tucker; Varghese John

Archive | 2001

Methods to treat alzheimer's disease

Roy K. Hom; Shumeye S. Mamo; Jay Tung; Andrea Gailunas; Varghese John; Lawrence Y. Fang

Archive | 2005

Dipeptide inhibitors of beta-secretase

Varghese John; Jay Tung; Ashley C. Guinn; Lawrence Fang; Andrea Gailunas; Shumeye S. Mamo

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Varghese John

Eli Lilly and Company

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Roy K. Hom

Upjohn

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John A. Tucker

Pfizer

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Barbara Jagodzinska

Buck Institute for Research on Aging

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Ruth E. Tenbrink

Upjohn

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John Mickelson

Upjohn

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Larry Fang

Upjohn

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Jay S. Tung

Thomas Jefferson University

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Lawrence Y. Fang

Eli Lilly and Company

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Michel Maillard

Institut de Chimie des Substances Naturelles

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